Saw my Dr yesterday

Forums General Melanoma Community Saw my Dr yesterday

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    caman
    Participant

      Considering the features of my Primary ive been fortunate it hasnt spread yet.  It will be 1 yr in April.  My Dr. told me today Immunotherapy only works in 40 percent of the patients.  Is that a true number?  I wonder if he meant 40 percent being cured rather than just prolonging life. 

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        caman
        Participant

          Sorry, that was me asking

          Bubbles
          Participant

            Yes, what your doc told you is true.  Anti-PD-1, whether nivolumab (Opdivo) or pembrolizumab (Keytruda), has what researchers refer to as a roughly "40% response rate" when used as a single agent. Meaning, of 100 patients with melanoma given the drug, 40 will respond and 60 will not.  Ipilimumab (Yervoy) has a 15% response rate.  These rates increase to 50+% when the ipi/nivo combo is utilized.  All of these drugs are categorized as 'immunotherapy'.  A positive about these responses is that with immunotherapy, researchers find that many of these responses are "durable"….meaning last over years.  There is more info under "immunotherapy" in this post if you are interested:

            https://chaoticallypreciselifeloveandmelanoma.blogspot.com/2017/08/melanoma-intel-primer-for-current.html  

            While melanoma therapy has made tremendous strides in the past 8 years….we clearly have a long way to go!  c

              caman
              Participant

                Thank you.  Any clue why some don't respond?…Is it age, features of the melanoma, genes, etc??

                Bubbles
                Participant

                  We don't really know.

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