higher recurrence rates than what I thought

Forums General Melanoma Community higher recurrence rates than what I thought

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      Janner
      Participant

        It IS way less than that in this day and age.  This study was from the 50's and the 60's.  The guidelines for removal were different then.  There was no Sentinel Node Biopsy (SNB) back then – it wasn't introduced until the 90's.  Things are changing so rapidly in the melanoma field that historical survival rates are useless now.  New treatments that exist aren't included in them.  Same with everything else.  You HAVE to look at dates to see how old things are because 60 years ago is not any indication of what you'd see today.

        Janner
        Participant

          It IS way less than that in this day and age.  This study was from the 50's and the 60's.  The guidelines for removal were different then.  There was no Sentinel Node Biopsy (SNB) back then – it wasn't introduced until the 90's.  Things are changing so rapidly in the melanoma field that historical survival rates are useless now.  New treatments that exist aren't included in them.  Same with everything else.  You HAVE to look at dates to see how old things are because 60 years ago is not any indication of what you'd see today.

          Janner
          Participant

            It IS way less than that in this day and age.  This study was from the 50's and the 60's.  The guidelines for removal were different then.  There was no Sentinel Node Biopsy (SNB) back then – it wasn't introduced until the 90's.  Things are changing so rapidly in the melanoma field that historical survival rates are useless now.  New treatments that exist aren't included in them.  Same with everything else.  You HAVE to look at dates to see how old things are because 60 years ago is not any indication of what you'd see today.

            JC
            Participant

              but unless the Breslows were incorrect, regardless of when the study was done, it is what it is, right?  also, as far as new treatments. . . Breslows that thin don't receive any treatments, so it wouldn't matter right?

              JC
              Participant

                but unless the Breslows were incorrect, regardless of when the study was done, it is what it is, right?  also, as far as new treatments. . . Breslows that thin don't receive any treatments, so it wouldn't matter right?

                JC
                Participant

                  but unless the Breslows were incorrect, regardless of when the study was done, it is what it is, right?  also, as far as new treatments. . . Breslows that thin don't receive any treatments, so it wouldn't matter right?

                    Janner
                    Participant

                      They were looking at Clark's Levels which are subjective (and no longer used).  And margins are they key.  Melanoma was not as prevalent then.  What margins were used?  Back then, they used to do a total LND as treatment.  This is a small study and old and not applicable to today.  Compare it against this study from 2004 where stage IA had 22,000+ study participants as opposed to 256.

                      http://www.asco.org/ASCOv2/Meetings/Abstracts?&vmview=abst_detail_view&confID=26&abstractID=3499

                      Janner
                      Participant

                        They were looking at Clark's Levels which are subjective (and no longer used).  And margins are they key.  Melanoma was not as prevalent then.  What margins were used?  Back then, they used to do a total LND as treatment.  This is a small study and old and not applicable to today.  Compare it against this study from 2004 where stage IA had 22,000+ study participants as opposed to 256.

                        http://www.asco.org/ASCOv2/Meetings/Abstracts?&vmview=abst_detail_view&confID=26&abstractID=3499

                        Janner
                        Participant

                          They were looking at Clark's Levels which are subjective (and no longer used).  And margins are they key.  Melanoma was not as prevalent then.  What margins were used?  Back then, they used to do a total LND as treatment.  This is a small study and old and not applicable to today.  Compare it against this study from 2004 where stage IA had 22,000+ study participants as opposed to 256.

                          http://www.asco.org/ASCOv2/Meetings/Abstracts?&vmview=abst_detail_view&confID=26&abstractID=3499

                          JC
                          Participant

                            are you referring to the WLE margins?  in a lot of cases anyway, the biopsy removed all of the tumor with thin lesions, the WLE is just for good measure but rarely finds any additional cancer cells, so I'm not sure how much margins mattered when talking about thin lesions

                            JC
                            Participant

                              are you referring to the WLE margins?  in a lot of cases anyway, the biopsy removed all of the tumor with thin lesions, the WLE is just for good measure but rarely finds any additional cancer cells, so I'm not sure how much margins mattered when talking about thin lesions

                              JC
                              Participant

                                are you referring to the WLE margins?  in a lot of cases anyway, the biopsy removed all of the tumor with thin lesions, the WLE is just for good measure but rarely finds any additional cancer cells, so I'm not sure how much margins mattered when talking about thin lesions

                                Janner
                                Participant

                                  WLE tissue is never analyzed to the same degree as biopsy tissue.  They look for "gross" cells, not individual ones.  So even if the WLE says clean margins or nothing found, that doesn't mean melanoma wasn't in the sample. 

                                  Janner
                                  Participant

                                    WLE tissue is never analyzed to the same degree as biopsy tissue.  They look for "gross" cells, not individual ones.  So even if the WLE says clean margins or nothing found, that doesn't mean melanoma wasn't in the sample. 

                                    Janner
                                    Participant

                                      WLE tissue is never analyzed to the same degree as biopsy tissue.  They look for "gross" cells, not individual ones.  So even if the WLE says clean margins or nothing found, that doesn't mean melanoma wasn't in the sample. 

                                    JC
                                    Participant

                                      this is more recent and even it says 15%

                                       

                                      http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1360111/

                                       

                                      JC
                                      Participant

                                        this is more recent and even it says 15%

                                         

                                        http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1360111/

                                         

                                        JC
                                        Participant

                                          this is more recent and even it says 15%

                                           

                                          http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1360111/

                                           

                                            Janner
                                            Participant

                                              15% includes 6.6% who were stage III at diagnosis.  They had positive sentinel nodes at the start.

                                              Janner
                                              Participant

                                                15% includes 6.6% who were stage III at diagnosis.  They had positive sentinel nodes at the start.

                                                Janner
                                                Participant

                                                  15% includes 6.6% who were stage III at diagnosis.  They had positive sentinel nodes at the start.

                                                JC
                                                Participant

                                                  TABLE II: Survival of Melanoma Patients by Tumor Thickness

                                                   

                                                  http://lifemath.net/cancer/about/techreports/technical_report_11.pdf

                                                  JC
                                                  Participant

                                                    TABLE II: Survival of Melanoma Patients by Tumor Thickness

                                                     

                                                    http://lifemath.net/cancer/about/techreports/technical_report_11.pdf

                                                    JC
                                                    Participant

                                                      TABLE II: Survival of Melanoma Patients by Tumor Thickness

                                                       

                                                      http://lifemath.net/cancer/about/techreports/technical_report_11.pdf

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