Sapporo73

Thanks all.  You guys are the best and really give me much needed positive support.  I kind of feel that these trials were made for folks who can tolerate a little more and I feel I fall into that category.  So aggressive yes, but would also absolutely love helping find the next best line of treatment for those that follow.  In process of getting second opinion this week though before I make a final decision.  Will let you all know.

Forgot to mention that have 5cm mass in left lung and smaller tumors spread across abdomen among other places.  MRI negative for spread to brain.  Surgery not an option and would head straight to immunotherapy trial.

Thanks all for the great input and issues to think about.  I am learning more and more about the characteristics of what I have every day.  The main reason I am leaning towards clinical trial of NKTR-214 and Nivo is the fact that I can probably tolerate a more aggressive treatment approach AND can always resort to a Nivo only course should I not respond to the Phase I/2 trial.  I feel like I have nothing to lose.  Initial reports from the study look promising and side effects look moderate.