k1ahmed

Hi Lesley

Thanks for the concern.

She was in hospital for 11 days and once colonoscopy was performed and colitis was confirmed and steriod treatment started, she got better quickly.  It is still a big issue with us on why it took this long to come to that conclusion. Anyways..

I cannot remember now what was her dose, I will go back and check and report to you .

Her history:  Primary tumor in eye detected and treated with plaque in 2001.  Met in liver detected in Nov. 2011 and confirmed with biopsy in Jan. 2012.  Size was about 1.4 cm, only one lesion.  Liver resection done late Jan. 2012 and no further mets found.  She had good margins.

Ipi started in April 2012 and the second infusion caused the colitis. 

Interstingly, we just talked to a melanoma expert (cutaneous melanoma) at karmanos institute and he said that he would have not prescribed Yervoy since she is NED and there is no way to measure the effectiveness of Yervoy. He suggested PET/CT every three months. 

Since resection, a catscan was done on her abdomen while in hospital (early this month) and it came out ok.

I have seen mixed reviews of Yervoy when stopped at 2 doses.  I guess there is not enough data to establish the effectiveness of this medicine.  This melanoma expert did say that some studies suggest that developing colitis (and other serious effects) show that the immune system may be ready to work as intended by Yervoy (killing cancer tumors).  Too early to tell, I guess in her case.

Thanks for all the support.

Hi Lesley

Thanks for the concern.

She was in hospital for 11 days and once colonoscopy was performed and colitis was confirmed and steriod treatment started, she got better quickly.  It is still a big issue with us on why it took this long to come to that conclusion. Anyways..

I cannot remember now what was her dose, I will go back and check and report to you .

Her history:  Primary tumor in eye detected and treated with plaque in 2001.  Met in liver detected in Nov. 2011 and confirmed with biopsy in Jan. 2012.  Size was about 1.4 cm, only one lesion.  Liver resection done late Jan. 2012 and no further mets found.  She had good margins.

Ipi started in April 2012 and the second infusion caused the colitis. 

Interstingly, we just talked to a melanoma expert (cutaneous melanoma) at karmanos institute and he said that he would have not prescribed Yervoy since she is NED and there is no way to measure the effectiveness of Yervoy. He suggested PET/CT every three months. 

Since resection, a catscan was done on her abdomen while in hospital (early this month) and it came out ok.

I have seen mixed reviews of Yervoy when stopped at 2 doses.  I guess there is not enough data to establish the effectiveness of this medicine.  This melanoma expert did say that some studies suggest that developing colitis (and other serious effects) show that the immune system may be ready to work as intended by Yervoy (killing cancer tumors).  Too early to tell, I guess in her case.

Thanks for all the support.

Hi Lesley

Thanks for the concern.

She was in hospital for 11 days and once colonoscopy was performed and colitis was confirmed and steriod treatment started, she got better quickly.  It is still a big issue with us on why it took this long to come to that conclusion. Anyways..

I cannot remember now what was her dose, I will go back and check and report to you .

Her history:  Primary tumor in eye detected and treated with plaque in 2001.  Met in liver detected in Nov. 2011 and confirmed with biopsy in Jan. 2012.  Size was about 1.4 cm, only one lesion.  Liver resection done late Jan. 2012 and no further mets found.  She had good margins.

Ipi started in April 2012 and the second infusion caused the colitis. 

Interstingly, we just talked to a melanoma expert (cutaneous melanoma) at karmanos institute and he said that he would have not prescribed Yervoy since she is NED and there is no way to measure the effectiveness of Yervoy. He suggested PET/CT every three months. 

Since resection, a catscan was done on her abdomen while in hospital (early this month) and it came out ok.

I have seen mixed reviews of Yervoy when stopped at 2 doses.  I guess there is not enough data to establish the effectiveness of this medicine.  This melanoma expert did say that some studies suggest that developing colitis (and other serious effects) show that the immune system may be ready to work as intended by Yervoy (killing cancer tumors).  Too early to tell, I guess in her case.

Thanks for all the support.

She is out of hospital, stablized and recovering from Colitis.  As I mentioned, yervoy is discontinued.

I had one consultation with Dr. Flaherty at Karmanos in Detroit.  Another one , we will have at U of M next week on the next steps.

At this time, the last scan (few weeks ago) showed her still NED.

She is out of hospital, stablized and recovering from Colitis.  As I mentioned, yervoy is discontinued.

I had one consultation with Dr. Flaherty at Karmanos in Detroit.  Another one , we will have at U of M next week on the next steps.

At this time, the last scan (few weeks ago) showed her still NED.

She is out of hospital, stablized and recovering from Colitis.  As I mentioned, yervoy is discontinued.

I had one consultation with Dr. Flaherty at Karmanos in Detroit.  Another one , we will have at U of M next week on the next steps.

At this time, the last scan (few weeks ago) showed her still NED.

After 2nd infusion of Yervoy, she developed serious nausea and diarahea.  It is highly questionable why her Oncologist didn't quickly realize the potential for colitis, which is a known side effect.  She went on for several days with Immodium and hydration but has developed a serious case of colitis.  She is told that there will be no more Yervoy infusion. 
We hope she recovers back soon but question is now:  what is next for therapy?  Any thoughts?

After 2nd infusion of Yervoy, she developed serious nausea and diarahea.  It is highly questionable why her Oncologist didn't quickly realize the potential for colitis, which is a known side effect.  She went on for several days with Immodium and hydration but has developed a serious case of colitis.  She is told that there will be no more Yervoy infusion. 
We hope she recovers back soon but question is now:  what is next for therapy?  Any thoughts?

After 2nd infusion of Yervoy, she developed serious nausea and diarahea.  It is highly questionable why her Oncologist didn't quickly realize the potential for colitis, which is a known side effect.  She went on for several days with Immodium and hydration but has developed a serious case of colitis.  She is told that there will be no more Yervoy infusion. 
We hope she recovers back soon but question is now:  what is next for therapy?  Any thoughts?