I started on the Roche phase II study back in Feb of 2010 at 960mg twice a day. The joint pain and swelling got really bad and I ended up hospitalized with pnenomia. They restated me at 720 and while the side effects can be bad, for me they seem to be cyclic and tolerable. I had the rash but it disappeared with the lower dose. As far as fatigue, it happens and Red Bull is my friend. I stay active and exercise which seems to help. It is hard sometimes, but I make myself do something. For the joint pain I have tried a number of things; lidocane patchs, MS cotin, tremadol, vicodin, motrin, etc. All have had varying degrees of success but I have settled on vicodin and motrin.
Joe
