I just finished Yervoy and am getting ready to start Zelboraf. I also have brain mets and have had whole brain radiation. For me, the whole brain radiation wasn't very effective, but I did have gamma knife surgery, which is a form of pinpoint radiation, which did help. Beware the side effects of the Yervoy were different for me with each infusion. I did have some success with the Yervoy though. Most of the tumors in my lungs shrunk, some by half. I did have new lesions that popped up during the Yervoy treatment though.
I would strongly reccommend looking into gamma or cyberknife as opposed to whole brain radiation. The side effects for me were mainly tiredness and hair loss, but it just wasn't effective.
