FayFighter

Thanks Jerry. Interesting piece.  We start the immunocore tues. First scans March 11th. We should know something on that day.  There is definitely tumor flare with this treatment.  The doctors aren't sure if the immunocore will cross bbb.  But they say it's a smaller molecule than pd1 and ctl4a. I will post next week about what we see. 

Thanks Jerry. Interesting piece.  We start the immunocore tues. First scans March 11th. We should know something on that day.  There is definitely tumor flare with this treatment.  The doctors aren't sure if the immunocore will cross bbb.  But they say it's a smaller molecule than pd1 and ctl4a. I will post next week about what we see. 

Thanks Jerry. Interesting piece.  We start the immunocore tues. First scans March 11th. We should know something on that day.  There is definitely tumor flare with this treatment.  The doctors aren't sure if the immunocore will cross bbb.  But they say it's a smaller molecule than pd1 and ctl4a. I will post next week about what we see. 

Yes Jerry. My husband does have an NRAS mutation.  We have discussed il2 off line (you sent me all the suggested prep for such treatment ).  The one thing that has changed from last we spoke is that he has two small brain mets, more in the liver, more sub qs. And small gastric tumor.  So.  Disease is progressing now that he got kicked off the Mek/cdk4 inhibitor trial. ( we don't regret the inhibitor. It gave us sept oct nov Dec with disease regression.   But now it's back on the move.  I am wondering how il2 does across the blood brain barrier. We go to NYC tomorrow to sign the immunocore consents.  Hoping hbg looks good. I have a feeling the ldh is going to be much higher than its ever been. Bummed. But we need to try this.  Plan b is the Abraxane/avastin with radiation to brain. But I want to do something with il2 before he gets too sick.  

Yes Jerry. My husband does have an NRAS mutation.  We have discussed il2 off line (you sent me all the suggested prep for such treatment ).  The one thing that has changed from last we spoke is that he has two small brain mets, more in the liver, more sub qs. And small gastric tumor.  So.  Disease is progressing now that he got kicked off the Mek/cdk4 inhibitor trial. ( we don't regret the inhibitor. It gave us sept oct nov Dec with disease regression.   But now it's back on the move.  I am wondering how il2 does across the blood brain barrier. We go to NYC tomorrow to sign the immunocore consents.  Hoping hbg looks good. I have a feeling the ldh is going to be much higher than its ever been. Bummed. But we need to try this.  Plan b is the Abraxane/avastin with radiation to brain. But I want to do something with il2 before he gets too sick.  

Yes Jerry. My husband does have an NRAS mutation.  We have discussed il2 off line (you sent me all the suggested prep for such treatment ).  The one thing that has changed from last we spoke is that he has two small brain mets, more in the liver, more sub qs. And small gastric tumor.  So.  Disease is progressing now that he got kicked off the Mek/cdk4 inhibitor trial. ( we don't regret the inhibitor. It gave us sept oct nov Dec with disease regression.   But now it's back on the move.  I am wondering how il2 does across the blood brain barrier. We go to NYC tomorrow to sign the immunocore consents.  Hoping hbg looks good. I have a feeling the ldh is going to be much higher than its ever been. Bummed. But we need to try this.  Plan b is the Abraxane/avastin with radiation to brain. But I want to do something with il2 before he gets too sick.  

I meant colitis "was" caused by yervoy. 

I meant colitis "was" caused by yervoy. 

I meant colitis "was" caused by yervoy. 

The pd1 kir was pretty short.  I think his colitis was not from yervoy he had oct – dec 2013. 

mskcc doesn't have any il2 trials. It's seems they think it's pretty toxic. 

they wanted to send him to NIH for il2 and cell transfer I believe at NIH but that didn't work because they wouldn't accept him. Colitis colon. 

because we know (gleaned from folks on this board ) that NRAS folks do pretty well on il2 we found a place 1/2 hour a way. But our doctor doesn't seem to psyched about it.  

In fact, if Immunocore doesn't work he want the Abraxane/Avastin with gamma.  

My husband wants to try il2.  I am wondering if il2 will kick up colon and that's why are doctor is not excited.  

The pd1 kir was pretty short.  I think his colitis was not from yervoy he had oct – dec 2013. 

mskcc doesn't have any il2 trials. It's seems they think it's pretty toxic. 

they wanted to send him to NIH for il2 and cell transfer I believe at NIH but that didn't work because they wouldn't accept him. Colitis colon. 

because we know (gleaned from folks on this board ) that NRAS folks do pretty well on il2 we found a place 1/2 hour a way. But our doctor doesn't seem to psyched about it.  

In fact, if Immunocore doesn't work he want the Abraxane/Avastin with gamma.  

My husband wants to try il2.  I am wondering if il2 will kick up colon and that's why are doctor is not excited.  

The pd1 kir was pretty short.  I think his colitis was not from yervoy he had oct – dec 2013. 

mskcc doesn't have any il2 trials. It's seems they think it's pretty toxic. 

they wanted to send him to NIH for il2 and cell transfer I believe at NIH but that didn't work because they wouldn't accept him. Colitis colon. 

because we know (gleaned from folks on this board ) that NRAS folks do pretty well on il2 we found a place 1/2 hour a way. But our doctor doesn't seem to psyched about it.  

In fact, if Immunocore doesn't work he want the Abraxane/Avastin with gamma.  

My husband wants to try il2.  I am wondering if il2 will kick up colon and that's why are doctor is not excited.  

From May to July he was on a pd1 anti Kir trial.  Just not sure we were able to tell it was working as he started with a 4.5 cm stomach tumor that grew to 8 cm. it had to come out and that knocked him out of that trial.  There is talk of using the "other" pd1.  Not sure what to do.   The Oncologist seems to want to do the Immunocore.  But I have never seen the melanoms grow as much as it did over the last 6 weeks.  We are very scared. 

From May to July he was on a pd1 anti Kir trial.  Just not sure we were able to tell it was working as he started with a 4.5 cm stomach tumor that grew to 8 cm. it had to come out and that knocked him out of that trial.  There is talk of using the "other" pd1.  Not sure what to do.   The Oncologist seems to want to do the Immunocore.  But I have never seen the melanoms grow as much as it did over the last 6 weeks.  We are very scared. 

From May to July he was on a pd1 anti Kir trial.  Just not sure we were able to tell it was working as he started with a 4.5 cm stomach tumor that grew to 8 cm. it had to come out and that knocked him out of that trial.  There is talk of using the "other" pd1.  Not sure what to do.   The Oncologist seems to want to do the Immunocore.  But I have never seen the melanoms grow as much as it did over the last 6 weeks.  We are very scared.