Dinoop

Art,

Just to add to what brian was saying , if there is a V600E you ahve a good chance of response to BRAF inhibitors or MEK inhibitors(Trametinib), but since you have tried BRAF inhibitors and as it do not seem to work, I am not really sure whether MEK inhibitors could work.

PD1 is basically a molecule that helps tumor to evade immune response so treatments like MK3475(PD1 blocking antibody) or similar antibody treatments may work better if your tumours express PD1 ,but also many times it work on persons negative for PD1, as basically what the antibody does is to inhibit your bodies normal immune suppressive events.

I would also have encouraged you to speak to your clinicians about drug holiday therapies with BRAF inhibitors or MEK inhibitors if you were responsive to it as it has been also shown recently that these drug holidays prevent emergence of resistance and you can have a controllable disease state.

but the most promising results currently for stage 4 melanoma is a combination of Yervoy (CTLA4 inhibitor) with PD1 inhibitor antibodies. if there are any trials with this combination ask your clinician to advice you.ANd it do not matter whether you have taken Yervoy before or not it always work better in combination with PD1 inhibitory antibodies.

Art,

Just to add to what brian was saying , if there is a V600E you ahve a good chance of response to BRAF inhibitors or MEK inhibitors(Trametinib), but since you have tried BRAF inhibitors and as it do not seem to work, I am not really sure whether MEK inhibitors could work.

PD1 is basically a molecule that helps tumor to evade immune response so treatments like MK3475(PD1 blocking antibody) or similar antibody treatments may work better if your tumours express PD1 ,but also many times it work on persons negative for PD1, as basically what the antibody does is to inhibit your bodies normal immune suppressive events.

I would also have encouraged you to speak to your clinicians about drug holiday therapies with BRAF inhibitors or MEK inhibitors if you were responsive to it as it has been also shown recently that these drug holidays prevent emergence of resistance and you can have a controllable disease state.

but the most promising results currently for stage 4 melanoma is a combination of Yervoy (CTLA4 inhibitor) with PD1 inhibitor antibodies. if there are any trials with this combination ask your clinician to advice you.ANd it do not matter whether you have taken Yervoy before or not it always work better in combination with PD1 inhibitory antibodies.

Art,

Just to add to what brian was saying , if there is a V600E you ahve a good chance of response to BRAF inhibitors or MEK inhibitors(Trametinib), but since you have tried BRAF inhibitors and as it do not seem to work, I am not really sure whether MEK inhibitors could work.

PD1 is basically a molecule that helps tumor to evade immune response so treatments like MK3475(PD1 blocking antibody) or similar antibody treatments may work better if your tumours express PD1 ,but also many times it work on persons negative for PD1, as basically what the antibody does is to inhibit your bodies normal immune suppressive events.

I would also have encouraged you to speak to your clinicians about drug holiday therapies with BRAF inhibitors or MEK inhibitors if you were responsive to it as it has been also shown recently that these drug holidays prevent emergence of resistance and you can have a controllable disease state.

but the most promising results currently for stage 4 melanoma is a combination of Yervoy (CTLA4 inhibitor) with PD1 inhibitor antibodies. if there are any trials with this combination ask your clinician to advice you.ANd it do not matter whether you have taken Yervoy before or not it always work better in combination with PD1 inhibitory antibodies.