Yervoy not working, what next?

Most likely your mother is not producing the "Danger Signal" need to activate the innate immune system. Radiation may help by killing the outer cancer cells of the tumor and producting Tumor-Specific Antigens. She also needs to break the tolerance of the T- regulator cells (Tregs) and the suppressive cytokines that are produced in the tumor's Microenvirnoment..

Please email me so we can talk off line and see what can be done in your mother's situation.

dbreitfe@rochester.rr.com

P.S. I don't want to go into too much detail online because it may confuse you and other followers. I would need more information on your mother's situation to be able to make an educated path forward.

If you feel uncomfortable about talking, check out my previous posts here at MRF or check out Melanoma Missionary blog

http://melanomamissionary.blogspot.com/ 

Most likely your mother is not producing the "Danger Signal" need to activate the innate immune system. Radiation may help by killing the outer cancer cells of the tumor and producting Tumor-Specific Antigens. She also needs to break the tolerance of the T- regulator cells (Tregs) and the suppressive cytokines that are produced in the tumor's Microenvirnoment..

Please email me so we can talk off line and see what can be done in your mother's situation.

dbreitfe@rochester.rr.com

P.S. I don't want to go into too much detail online because it may confuse you and other followers. I would need more information on your mother's situation to be able to make an educated path forward.

If you feel uncomfortable about talking, check out my previous posts here at MRF or check out Melanoma Missionary blog

http://melanomamissionary.blogspot.com/ 

Most likely your mother is not producing the "Danger Signal" need to activate the innate immune system. Radiation may help by killing the outer cancer cells of the tumor and producting Tumor-Specific Antigens. She also needs to break the tolerance of the T- regulator cells (Tregs) and the suppressive cytokines that are produced in the tumor's Microenvirnoment..

Please email me so we can talk off line and see what can be done in your mother's situation.

dbreitfe@rochester.rr.com

P.S. I don't want to go into too much detail online because it may confuse you and other followers. I would need more information on your mother's situation to be able to make an educated path forward.

If you feel uncomfortable about talking, check out my previous posts here at MRF or check out Melanoma Missionary blog

http://melanomamissionary.blogspot.com/ 

Unfortunately, Yervoy only works in about 15% of patients. I don't think anybody knows why. Has your mother's tumor been tested for the BRAF mutation? What treatment is your oncolgist recommending?

Unfortunately, Yervoy only works in about 15% of patients. I don't think anybody knows why. Has your mother's tumor been tested for the BRAF mutation? What treatment is your oncolgist recommending?

Unfortunately, Yervoy only works in about 15% of patients. I don't think anybody knows why. Has your mother's tumor been tested for the BRAF mutation? What treatment is your oncolgist recommending?

See my post called "Redirecting the Melanoma Tumor’s Microenvironment in Favor of the Activation of T-cells "

Posted on 3-15-2012

Best regards,

Jimmy B

See my post called "Redirecting the Melanoma Tumor’s Microenvironment in Favor of the Activation of T-cells "

Posted on 3-15-2012

Best regards,

Jimmy B

See my post called "Redirecting the Melanoma Tumor’s Microenvironment in Favor of the Activation of T-cells "

Posted on 3-15-2012

Best regards,

Jimmy B

Don't be surprised by the 'Low " sound of only 15-20% of Yervoy (Ippi) helping melanoma patients.  The only other treatment that has been in this ballpark is IL-2 which was approved in 1998.  Most treatments of other things have trouble reaching a 1% helpful rate.  IL-2 has provided what approaches a 5% "cure" rate in across the board melanoma patients, while providing a benefit to another 15% of across the board melanoma patients.  A second drug to provide assistance in this range is a good step forward, while not being a solution for all.  An interesting thing is that in many cases it appears that both Yervoy and IL-2 can help pump up ones system so that other treatments become more effective than they normally are if taken independently. 

  Jimmy B got very deep into analyzing why/how this may happen since it appears that his disease failed to the Yervoy treatments and then responded after IL-2 treatments.  Jimmy did an amazing analysis of how this could happen and has impressed some well known Oncology researchers with his work of the timing of events that led to his becoming NED!

   I would be comfortable with providing Jimmy any information available on myself to assist him in his analysis.

      I have not had the Yervoy, but the IL-2 held my innumerable lung tumors essentially stable for 20 months before they started growing again.   My Liver tumors have never started growing again and appear to likely be necrotic tissue (dead tumors).  IL-2, while a tough treatment in the short term, provides a fairly rapid response if one is responding to it, and has a short recovery period from its side effects.  It should definitely be an option on the table.  

You do want to be sure that it is administered by a highly experienced IL-2 team.  I know people that have had IL-2 as their only Stage IV treatment that have been NED (Cured?) for from 5 to 21 years as of now.

Don't be surprised by the 'Low " sound of only 15-20% of Yervoy (Ippi) helping melanoma patients.  The only other treatment that has been in this ballpark is IL-2 which was approved in 1998.  Most treatments of other things have trouble reaching a 1% helpful rate.  IL-2 has provided what approaches a 5% "cure" rate in across the board melanoma patients, while providing a benefit to another 15% of across the board melanoma patients.  A second drug to provide assistance in this range is a good step forward, while not being a solution for all.  An interesting thing is that in many cases it appears that both Yervoy and IL-2 can help pump up ones system so that other treatments become more effective than they normally are if taken independently. 

  Jimmy B got very deep into analyzing why/how this may happen since it appears that his disease failed to the Yervoy treatments and then responded after IL-2 treatments.  Jimmy did an amazing analysis of how this could happen and has impressed some well known Oncology researchers with his work of the timing of events that led to his becoming NED!

   I would be comfortable with providing Jimmy any information available on myself to assist him in his analysis.

      I have not had the Yervoy, but the IL-2 held my innumerable lung tumors essentially stable for 20 months before they started growing again.   My Liver tumors have never started growing again and appear to likely be necrotic tissue (dead tumors).  IL-2, while a tough treatment in the short term, provides a fairly rapid response if one is responding to it, and has a short recovery period from its side effects.  It should definitely be an option on the table.  

You do want to be sure that it is administered by a highly experienced IL-2 team.  I know people that have had IL-2 as their only Stage IV treatment that have been NED (Cured?) for from 5 to 21 years as of now.

Don't be surprised by the 'Low " sound of only 15-20% of Yervoy (Ippi) helping melanoma patients.  The only other treatment that has been in this ballpark is IL-2 which was approved in 1998.  Most treatments of other things have trouble reaching a 1% helpful rate.  IL-2 has provided what approaches a 5% "cure" rate in across the board melanoma patients, while providing a benefit to another 15% of across the board melanoma patients.  A second drug to provide assistance in this range is a good step forward, while not being a solution for all.  An interesting thing is that in many cases it appears that both Yervoy and IL-2 can help pump up ones system so that other treatments become more effective than they normally are if taken independently. 

  Jimmy B got very deep into analyzing why/how this may happen since it appears that his disease failed to the Yervoy treatments and then responded after IL-2 treatments.  Jimmy did an amazing analysis of how this could happen and has impressed some well known Oncology researchers with his work of the timing of events that led to his becoming NED!

   I would be comfortable with providing Jimmy any information available on myself to assist him in his analysis.

      I have not had the Yervoy, but the IL-2 held my innumerable lung tumors essentially stable for 20 months before they started growing again.   My Liver tumors have never started growing again and appear to likely be necrotic tissue (dead tumors).  IL-2, while a tough treatment in the short term, provides a fairly rapid response if one is responding to it, and has a short recovery period from its side effects.  It should definitely be an option on the table.  

You do want to be sure that it is administered by a highly experienced IL-2 team.  I know people that have had IL-2 as their only Stage IV treatment that have been NED (Cured?) for from 5 to 21 years as of now.