Where and when will this new trial be conducted (March?)

This topic has 6 replies, 2 voices, and was last updated 12 years ago by JerryfromFauq.

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- February 6, 2014 at 4:42 am
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JerryfromFauq
Participant
Receive OK From FDA to Proceed With Phase 1B Clinical Trial in Metastatic Melanoma

NORCROSS, Ga., Feb. 3, 2014 (GLOBE NEWSWIRE) — Galectin Therapeutics Inc. (GALT), the leading developer of therapeutics that target galectin proteins to treat fibrosis and cancer, today announced that the U.S. Food and Drug Administration (FDA) has agreed that a Phase 1B clinical trial of the galectin inhibitor GR-MD-02 in combination with Yervoy(R) (ipilimumab) in patients with metastatic melanoma may proceed. Providence Portland Medical Center, a leader in immunotherapy research and translational clinical trials in melanoma and other cancers, filed the IND in late December 2013.

Providence Portland Medical Center's Earle A. Chiles Research Institute (EACRI) will conduct the Phase 1B study under principal investigator Brendan D. Curti, M.D. The study will employ a 3+3 Phase 1 design with dose escalation of GR-MD-02 in conjunction with the standard therapeutic dose of ipilimumab in patients with advanced melanoma for whom ipilimumab would be considered standard of care. Researchers will assess the effects of GR-MD-02 with ipilimumab on melanoma response by inducing proliferation, activation and memory function of CD8+ T cells. In addition to monitoring for toxicity and clinical response, blood samples will be obtained to assess immunologic measures relevant to galectin biology and ipilimumab T-cell check-point inhibition.

http://finance.yahoo.com/news/galectin-therapeutics-providence-portland-medical-163000237.html

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- - February 6, 2014 at 5:11 am
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  POW
  Participant
  I don't know where this trial will be conducted but I did find an interesting article about this company's melanoma research: http://galectintherapeutics.com/what-we-do/develop-proprietary-compounds-for-disease/development-program/
  
  Note that the last trial (conducted in France) terminated early because they could not find 12 treatment naive patients. Wow! Such changes in the world of melanoma.
- - February 6, 2014 at 5:11 am
  - Quote
  POW
  Participant
  I don't know where this trial will be conducted but I did find an interesting article about this company's melanoma research: http://galectintherapeutics.com/what-we-do/develop-proprietary-compounds-for-disease/development-program/
  
  Note that the last trial (conducted in France) terminated early because they could not find 12 treatment naive patients. Wow! Such changes in the world of melanoma.
  - February 6, 2014 at 5:21 am
    
    Quote
    JerryfromFauq
    Participant
    
    Thanks. So it may not even be in the US that they actually do a trial. i know some people in Ga that might would be interested.
  - February 6, 2014 at 5:21 am
    
    Quote
    JerryfromFauq
    Participant
    
    Thanks. So it may not even be in the US that they actually do a trial. i know some people in Ga that might would be interested.
  - February 6, 2014 at 5:21 am
    
    Quote
    JerryfromFauq
    Participant
    
    Thanks. So it may not even be in the US that they actually do a trial. i know some people in Ga that might would be interested.
- - February 6, 2014 at 5:11 am
  - Quote
  POW
  Participant
  I don't know where this trial will be conducted but I did find an interesting article about this company's melanoma research: http://galectintherapeutics.com/what-we-do/develop-proprietary-compounds-for-disease/development-program/
  
  Note that the last trial (conducted in France) terminated early because they could not find 12 treatment naive patients. Wow! Such changes in the world of melanoma.

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Where and when will this new trial be conducted (March?)

Receive OK From FDA to Proceed With Phase 1B Clinical Trial in Metastatic Melanoma

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Where and when will this new trial be conducted (March?)

Receive OK From FDA to Proceed With Phase 1B Clinical Trial in Metastatic Melanoma

About the MRF Patient Forum

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