› Forums › General Melanoma Community › Tumour burden
- This topic has 9 replies, 2 voices, and was last updated 9 years, 3 months ago by
Scooby123.
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- December 2, 2016 at 2:33 pm
It can be any combonation of all that you have mentioned. It's the combined total of cancer cells within the body. Whether that is one tumor, or several of them added together. I'm not certain how one is classified as "high" or "low" though. Is there a set total volume that would put a person into one category or the other? I would imagine things are more complicated than that, because there is also a tumor grade… which is gauged by how abnormal the cells are, and their likelihood to spread or grow. To add fuel to the fire of confusion, there is also the RECIST criteria to evaluate the efficacy of treatment the patient has had on their targeted tumors.
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- December 2, 2016 at 2:57 pm
After doing some digging around, I'm not entirely certain there is anything other than a very broad definition for high versus medium or low. In a book from 2013, there was a rough estimate made…
And then in a paper from 2014, this was the general definition given:
http://cco.amegroups.com/article/view/4303/5242#definition-of-tumor-burden
"Tumor burden refers to the total amount of cancer tissue in the body. The survival of a patient relates to the tumor burden, disease location and, most importantly, the pace of the disease. In general, patients with high tumor have a high pace of disease and, therefore, a very short survival without therapy. On the other hand, patients with low tumor burden usually have low pace disease and long survival even without therapy. However, these are only the extremes of the disease spectrum, which encompasses a range of clinical scenarios.
High tumor burden will be defined in this paper as large volume of total disease identified by imaging studies in patients who have disease related symptoms and/or elevated serum LDH. Low tumor burden will be defined as low volume disease by imaging studies, with minimal or no symptoms and normal serum LDH."
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- December 2, 2016 at 2:57 pm
After doing some digging around, I'm not entirely certain there is anything other than a very broad definition for high versus medium or low. In a book from 2013, there was a rough estimate made…
And then in a paper from 2014, this was the general definition given:
http://cco.amegroups.com/article/view/4303/5242#definition-of-tumor-burden
"Tumor burden refers to the total amount of cancer tissue in the body. The survival of a patient relates to the tumor burden, disease location and, most importantly, the pace of the disease. In general, patients with high tumor have a high pace of disease and, therefore, a very short survival without therapy. On the other hand, patients with low tumor burden usually have low pace disease and long survival even without therapy. However, these are only the extremes of the disease spectrum, which encompasses a range of clinical scenarios.
High tumor burden will be defined in this paper as large volume of total disease identified by imaging studies in patients who have disease related symptoms and/or elevated serum LDH. Low tumor burden will be defined as low volume disease by imaging studies, with minimal or no symptoms and normal serum LDH."
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- December 2, 2016 at 2:57 pm
After doing some digging around, I'm not entirely certain there is anything other than a very broad definition for high versus medium or low. In a book from 2013, there was a rough estimate made…
And then in a paper from 2014, this was the general definition given:
http://cco.amegroups.com/article/view/4303/5242#definition-of-tumor-burden
"Tumor burden refers to the total amount of cancer tissue in the body. The survival of a patient relates to the tumor burden, disease location and, most importantly, the pace of the disease. In general, patients with high tumor have a high pace of disease and, therefore, a very short survival without therapy. On the other hand, patients with low tumor burden usually have low pace disease and long survival even without therapy. However, these are only the extremes of the disease spectrum, which encompasses a range of clinical scenarios.
High tumor burden will be defined in this paper as large volume of total disease identified by imaging studies in patients who have disease related symptoms and/or elevated serum LDH. Low tumor burden will be defined as low volume disease by imaging studies, with minimal or no symptoms and normal serum LDH."
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- December 2, 2016 at 2:33 pm
It can be any combonation of all that you have mentioned. It's the combined total of cancer cells within the body. Whether that is one tumor, or several of them added together. I'm not certain how one is classified as "high" or "low" though. Is there a set total volume that would put a person into one category or the other? I would imagine things are more complicated than that, because there is also a tumor grade… which is gauged by how abnormal the cells are, and their likelihood to spread or grow. To add fuel to the fire of confusion, there is also the RECIST criteria to evaluate the efficacy of treatment the patient has had on their targeted tumors.
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- December 2, 2016 at 2:33 pm
It can be any combonation of all that you have mentioned. It's the combined total of cancer cells within the body. Whether that is one tumor, or several of them added together. I'm not certain how one is classified as "high" or "low" though. Is there a set total volume that would put a person into one category or the other? I would imagine things are more complicated than that, because there is also a tumor grade… which is gauged by how abnormal the cells are, and their likelihood to spread or grow. To add fuel to the fire of confusion, there is also the RECIST criteria to evaluate the efficacy of treatment the patient has had on their targeted tumors.
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