Targeted drug attack problems – example from c-kit work

› Forums › General Melanoma Community › Targeted drug attack problems – example from c-kit work

  • This topic is empty.
  • Post
    • August 30, 2011 at 7:08 pm
    JerryfromFauq
    Participant

      http://mct.aacrjournals.org/content/6/3/1159.full

      Long article that discusses c-kit mutations and resistance to treatments.

      I would expect similar modes of findings in all of the targeted attacks on different mutations other than just c-kit.  This shows what the medical research is up against in attempting to narrow the attack on each mutation in each type of cancer (even within the different types of c-kit melanoma!).  

      The introduction, results and Discussion sections are especially interesting.
      Wish I had a better background to understand the details even better.

      The article sections are:
       

      Abstract

      Introduction

      Materials and Methods

      c-KIT Expression in FDC-P1 Cells

      c-KIT Kinase Inhibitory Drugs

      Immunofluorescence Assay

      Cell Proliferation Assay

      Immunoprecipitation and Western Blot Analysis

      Structural Analysis

      Results

      Expression Levels of c-KIT in FDC-P1 Cells

      Preliminary Studies with V654A Mutant c-KIT

      Effect of the V654A Substitution in Combination with V560G, an Activating Mutation Characteristic of GIST, on Drug Sensitivity

      Effect of Kinase Inhibitors on c-KIT Phosphorylation

      Discussion

    • You must be logged in to reply to this topic.
    About the MRF Patient Forum

    The MRF Patient Forum is the oldest and largest online community of people affected by melanoma. It is designed to provide peer support and information to caregivers, patients, family and friends. There is no better place to discuss different parts of your journey with this cancer and find the friends and support resources to make that journey more bearable.

    The information on the forum is open and accessible to everyone. To add a new topic or to post a reply, you must be a registered user. Please note that you will be able to post both topics and replies anonymously even though you are logged in. All posts must abide by MRF posting policies.

    Popular Topics