ROLLCALL: BRAF& MEK combination trial

› Forums › General Melanoma Community › ROLLCALL: BRAF& MEK combination trial

  • Post
    • September 22, 2011 at 3:33 pm
    killmel
    Participant

      Hi,

       

      I am a newbie and need your help. I just turned Stage 4 and my doctor is recommending GSK Braf/MEK combo trial. I have have subq on leg, chest and mets on both lungs.

      I sincerely would appreciate any feedback / experience with the BRAF & Mek combination drug.

      I am very interested in knowing in the following:

      1. how long it took to see tumor shrinkage ?

      2. how long has the combo drugs been working  OR Stopped working?

      3. anyone get rid of ALL there tumors with this combo drug and remained NED??

      Hi,

       

      I am a newbie and need your help. I just turned Stage 4 and my doctor is recommending GSK Braf/MEK combo trial. I have have subq on leg, chest and mets on both lungs.

      I sincerely would appreciate any feedback / experience with the BRAF & Mek combination drug.

      I am very interested in knowing in the following:

      1. how long it took to see tumor shrinkage ?

      2. how long has the combo drugs been working  OR Stopped working?

      3. anyone get rid of ALL there tumors with this combo drug and remained NED??

      4.  what side effects have you experienced

       

      Thank you so much for taking the time to reply to my questions. I wish you all a status of NED.

      Nancy

    Viewing 1 reply thread
    • Replies
        • September 22, 2011 at 7:24 pm
        Harry in Fair Oaks
        Participant

          I've been on a GSK BRAF/MEK trial  (BRF113220) since May.  I take 300mg of the BRAF and 2 mg of the MEK daily.  Other than some fevers/chills experienced at week 4-5, I have only mild side effects, mostly fatigue.

          Going into the trial, I had bone mets, sub q's, and a possible lung met.  Sub q's went away within 4 weeks, and the lung lesion was not visible in the 8-week scan.  My last scans (16-week) showed bone mets all unchanged or slightly smaller (it's hard to tell if they are still active or not – a PET scan might show if they are still viable, but PET scanning is not part of the trial protocol).

          So I'm very happy with results so far.

          Best wishes,

          Harry

           

          • September 22, 2011 at 7:24 pm
          Harry in Fair Oaks
          Participant

            I've been on a GSK BRAF/MEK trial  (BRF113220) since May.  I take 300mg of the BRAF and 2 mg of the MEK daily.  Other than some fevers/chills experienced at week 4-5, I have only mild side effects, mostly fatigue.

            Going into the trial, I had bone mets, sub q's, and a possible lung met.  Sub q's went away within 4 weeks, and the lung lesion was not visible in the 8-week scan.  My last scans (16-week) showed bone mets all unchanged or slightly smaller (it's hard to tell if they are still active or not – a PET scan might show if they are still viable, but PET scanning is not part of the trial protocol).

            So I'm very happy with results so far.

            Best wishes,

            Harry

             

        Viewing 1 reply thread
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