Nivolumab and Ipilimumab combo

› Forums › General Melanoma Community › Nivolumab and Ipilimumab combo

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    • March 24, 2015 at 2:09 am
    Kathy himes
    Participant

      Hi. My wife has started treatment and after one cycle her liver enzymes have shot up. Has anyone gone through this?. Thanks, Doug

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        • March 24, 2015 at 3:07 am
        dvd
        Participant

          I was on the BMS ipi plus nivo or placebo trial last year. Although a blinded trial, all indications are that I received nivo rather than the placebo (ipi 3mg/kg + nivo 1mg/kg). After 4 doses over 3 months my hepatic enzymes spiked to about 8X normal, although I was asymptomatic. I was teminated from the trial (I was NED by then and have remained so) and put on a tapering dose of steroids which brought my liver function tests back to normal over the next 2 months.

          That combination, although remarkably effective, does have a majority of patients getting significant side effects. I have heard of patients having their side effects being treated with steroids but, in some cases, continuing with infusions.

          Best of luck – hope things work out for continued immunotherapy treatments.

          DVD

            • March 24, 2015 at 5:15 pm
            Kathy himes
            Participant

              Thanks so much for your inputs. Good luck. 

              • March 24, 2015 at 5:15 pm
              Kathy himes
              Participant

                Thanks so much for your inputs. Good luck. 

                • March 24, 2015 at 5:15 pm
                Kathy himes
                Participant

                  Thanks so much for your inputs. Good luck. 

                • March 24, 2015 at 3:07 am
                dvd
                Participant

                  I was on the BMS ipi plus nivo or placebo trial last year. Although a blinded trial, all indications are that I received nivo rather than the placebo (ipi 3mg/kg + nivo 1mg/kg). After 4 doses over 3 months my hepatic enzymes spiked to about 8X normal, although I was asymptomatic. I was teminated from the trial (I was NED by then and have remained so) and put on a tapering dose of steroids which brought my liver function tests back to normal over the next 2 months.

                  That combination, although remarkably effective, does have a majority of patients getting significant side effects. I have heard of patients having their side effects being treated with steroids but, in some cases, continuing with infusions.

                  Best of luck – hope things work out for continued immunotherapy treatments.

                  DVD

                  • March 24, 2015 at 3:07 am
                  dvd
                  Participant

                    I was on the BMS ipi plus nivo or placebo trial last year. Although a blinded trial, all indications are that I received nivo rather than the placebo (ipi 3mg/kg + nivo 1mg/kg). After 4 doses over 3 months my hepatic enzymes spiked to about 8X normal, although I was asymptomatic. I was teminated from the trial (I was NED by then and have remained so) and put on a tapering dose of steroids which brought my liver function tests back to normal over the next 2 months.

                    That combination, although remarkably effective, does have a majority of patients getting significant side effects. I have heard of patients having their side effects being treated with steroids but, in some cases, continuing with infusions.

                    Best of luck – hope things work out for continued immunotherapy treatments.

                    DVD

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