new drug expected this year

This topic has 5 replies, 4 voices, and was last updated 8 years, 2 months ago by mrsaxde.

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- January 15, 2018 at 8:07 pm
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JC
Participant
Epacadostat; Incyte:

This drug could be the year’s most-anticipated cancer immunotherapy. Designed as a first-line treatment for metastatic melanoma, it’s used in combination with Merck’s Keytruda. Studies have shown that 56 percent of melanoma patients treated with the combination responded to the therapy for a median 45 weeks, and their cancer didn’t progress for a median 12.4 months. The FDA probably won’t approve the drug until late in the year, given the hurdles still facing Incyte.

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- - January 16, 2018 at 2:13 pm
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  cancersnewnormal
  Participant
  The more weaponry in the arsenal the more wins we'll have! After reading that posted paragraph, I was interested in more… soooo… for anyone else with my same sense of curiosity… here's more: https://www.fiercebiotech.com/biotech/early-keytruda-combo-data-paint-incyte-s-epacadostat-as-a-threat-to-bristol-myers-i-o
  - January 16, 2018 at 3:06 pm
    
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    ed williams
    Participant
    
    Thanks Niki, this is the next big jump and hopefully soon!!! If you want to listen to a very positve video about what is coming for hot and cold tumors and new combination, try out the link below to Onclive from last summer with Dr.Long from Australia, Dr. Jason Luke from Chicago and Dr. Weber from New York!!! http://www.onclive.com/peer-exchange/advanced-melanoma-management/ido-inhibitors-in-metastatic-melanoma
- - January 16, 2018 at 7:23 pm
  - Quote
  Bubbles
  Participant
  I've got my fingers crossed on this one!! Thanks for posting, anon. Nikki, if you are interested in still more, here is a link to the report I made about the abstracts from the ECHO 204/ECHO 301 trials this past year as well as links to prior posts: http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2017/07/pembro-keytruda-and-epacadostat.html
  
  Thanks, ratties! Here's hoping! celeste
  - January 17, 2018 at 5:25 pm
    
    Quote
    cancersnewnormal
    Participant
    
    Thanks for the extra info Ed and Celeste! I'm not sure how I managed to miss this info this past summer. I think I did too much poking through ASCO abstracts, and not enough absorbing and retaining the information. ; )
    
    A friend sent me this yesterday: https://www.rdmag.com/news/2018/01/researchers-identify-new-treatment-target-melanoma?et_cid=6235674&et_rid=45588097&location=top&et_cid=6235674&et_rid=45588097&linkid=content
    
    Kind of an interesting project… although still in mouse stages. I'm curious to see if this one goes anywhere, only because it seems that the patient stories I see, seem to show women having worsening/advancing of their melanoma stage in the short run following a pregnancy. Obviously, a pregnancy is a challange for the body, and there are certainly other hormonal factors at play that will have cause/effect connections. But I'd like to see what this synthetic GPER could do with human cells and making those "cold" tumors a little warmer and more visible to the attacking army.
- - January 18, 2018 at 6:58 pm
  - Quote
  mrsaxde
  Participant
  I've been following the trial involving epacadostat for probably a year or more now. It has always looked promising. Glad to know that it's proving effective enough to move ahead with!
  
  -Bill

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