Keytruda 3 weeks into treatment, high LDH levels

Hopefully someone here knows. My highest was last December was 840. Which was considered really high. 100 to 250 they considered at my clinic normal. Mine dropped in late February after lots of radiation and continued to drop until late April to 350. Then started raising and is already at 600. So I'm concerned as well.

It is not a very good indicator but for me it has been fairly accurate. Basically there is a protein in our blood that melanoma cells like to tag along with. Thus they measure that protein in our blood and figure based on that the amount of Mel cells in our blood.

There should have been on the ldh report a range of what they consider normal at her clinic. It could be that 4000 there is 400 at my clinic. Might want to check with them. Otherwise 4000 is very high.

But it could also be a good thing if that is very high. Although she just got one dose it could be it has wiped out most of her cancer super fast thus that huge number is the processing of the dead cancer cells out of her body. In a few weeks if that is the case it would return to normal I would think. Maybe that's hoping too much but it could be.

Artie

Hopefully someone here knows. My highest was last December was 840. Which was considered really high. 100 to 250 they considered at my clinic normal. Mine dropped in late February after lots of radiation and continued to drop until late April to 350. Then started raising and is already at 600. So I'm concerned as well.

It is not a very good indicator but for me it has been fairly accurate. Basically there is a protein in our blood that melanoma cells like to tag along with. Thus they measure that protein in our blood and figure based on that the amount of Mel cells in our blood.

There should have been on the ldh report a range of what they consider normal at her clinic. It could be that 4000 there is 400 at my clinic. Might want to check with them. Otherwise 4000 is very high.

But it could also be a good thing if that is very high. Although she just got one dose it could be it has wiped out most of her cancer super fast thus that huge number is the processing of the dead cancer cells out of her body. In a few weeks if that is the case it would return to normal I would think. Maybe that's hoping too much but it could be.

Artie

Hopefully someone here knows. My highest was last December was 840. Which was considered really high. 100 to 250 they considered at my clinic normal. Mine dropped in late February after lots of radiation and continued to drop until late April to 350. Then started raising and is already at 600. So I'm concerned as well.

It is not a very good indicator but for me it has been fairly accurate. Basically there is a protein in our blood that melanoma cells like to tag along with. Thus they measure that protein in our blood and figure based on that the amount of Mel cells in our blood.

There should have been on the ldh report a range of what they consider normal at her clinic. It could be that 4000 there is 400 at my clinic. Might want to check with them. Otherwise 4000 is very high.

But it could also be a good thing if that is very high. Although she just got one dose it could be it has wiped out most of her cancer super fast thus that huge number is the processing of the dead cancer cells out of her body. In a few weeks if that is the case it would return to normal I would think. Maybe that's hoping too much but it could be.

Artie

I'd look at the unit of measurement.  Europe's scale seems higher than the one used in the US.  300 is considered high using the US scale (assuming that there is only one in the US–not sure).  The high end of the normal range is around 195.  That said, while I always watch my LDH, it is considered more relevant for those not on treatment since treatment may cause inflammation, etc. and raise LDH.

I'd look at the unit of measurement.  Europe's scale seems higher than the one used in the US.  300 is considered high using the US scale (assuming that there is only one in the US–not sure).  The high end of the normal range is around 195.  That said, while I always watch my LDH, it is considered more relevant for those not on treatment since treatment may cause inflammation, etc. and raise LDH.

I'd look at the unit of measurement.  Europe's scale seems higher than the one used in the US.  300 is considered high using the US scale (assuming that there is only one in the US–not sure).  The high end of the normal range is around 195.  That said, while I always watch my LDH, it is considered more relevant for those not on treatment since treatment may cause inflammation, etc. and raise LDH.