Just need some input

Forums General Melanoma Community Just need some input

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    deardad
    Participant

      Hi just want ask you all for your opinion.

      Recently my dad saw his neurosurgeon who told him that his latest MRI (after 4 months) was clear (hooray). He also asked if dad was going to have radiation. Apparently the neurosurgeon and the oncologist work independent of each other so he was not aware that my dad was on vemurafenib. When on a trial can you have WBR? Does anyone think it's worth considering? Do we have any evidence that vermurafenib crosses the blood brain barrier?

      Hi just want ask you all for your opinion.

      Recently my dad saw his neurosurgeon who told him that his latest MRI (after 4 months) was clear (hooray). He also asked if dad was going to have radiation. Apparently the neurosurgeon and the oncologist work independent of each other so he was not aware that my dad was on vemurafenib. When on a trial can you have WBR? Does anyone think it's worth considering? Do we have any evidence that vermurafenib crosses the blood brain barrier?

       I know that we are in a good place at the moment and I am so grateful, I just want dad to have access to something more durable while the disease is at bay (so to speak). I don't think you can move onto anything else until the disease progresses.

      Thanks in advance

      Nahmi from Melbourne

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    • Replies
        FormerCaregiver
        Participant

          Nahmi, if your dad has a clear brain MRI I can see no need for WBR. Radiation treatment
          can have significant side effects, and it has to be considered in light of any potential
          benefit to the patient.

          I am not certain if vemurafenib (Zelboraf) crosses the blood brain barrier, as it
          appears to act indirectly on brain mets. See:
          http://www.melanoma.org/community/mpip-melanoma-patients-information-page/zelboraf-brain-tumors-anyone#comment-25354

          Take care

          Frank from Australia

          FormerCaregiver
          Participant

            Nahmi, if your dad has a clear brain MRI I can see no need for WBR. Radiation treatment
            can have significant side effects, and it has to be considered in light of any potential
            benefit to the patient.

            I am not certain if vemurafenib (Zelboraf) crosses the blood brain barrier, as it
            appears to act indirectly on brain mets. See:
            http://www.melanoma.org/community/mpip-melanoma-patients-information-page/zelboraf-brain-tumors-anyone#comment-25354

            Take care

            Frank from Australia

            FormerCaregiver
            Participant

              Nahmi, if your dad has a clear brain MRI I can see no need for WBR. Radiation treatment
              can have significant side effects, and it has to be considered in light of any potential
              benefit to the patient.

              I am not certain if vemurafenib (Zelboraf) crosses the blood brain barrier, as it
              appears to act indirectly on brain mets. See:
              http://www.melanoma.org/community/mpip-melanoma-patients-information-page/zelboraf-brain-tumors-anyone#comment-25354

              Take care

              Frank from Australia

              LynnLuc
              Participant

                He best check with his primary oncologist doing the trial…if you do other things not part of the trial -they will  kick you out of the trial! -Lynn

                LynnLuc
                Participant

                  He best check with his primary oncologist doing the trial…if you do other things not part of the trial -they will  kick you out of the trial! -Lynn

                  LynnLuc
                  Participant

                    He best check with his primary oncologist doing the trial…if you do other things not part of the trial -they will  kick you out of the trial! -Lynn

                    jmmm
                    Participant
                      They found a big brain tumor in my husband last week. It’s too big to remove. His dr. Has worked with zalboraf trials for awhile and has seen it work on brain tumors although officially there is no data on it. I know you have to be off of zalboraf for a week before any type of radiation. I’d check with the oncologist to see his opinion.
                      L
                      jmmm
                      Participant
                        They found a big brain tumor in my husband last week. It’s too big to remove. His dr. Has worked with zalboraf trials for awhile and has seen it work on brain tumors although officially there is no data on it. I know you have to be off of zalboraf for a week before any type of radiation. I’d check with the oncologist to see his opinion.
                        L
                        jmmm
                        Participant
                          They found a big brain tumor in my husband last week. It’s too big to remove. His dr. Has worked with zalboraf trials for awhile and has seen it work on brain tumors although officially there is no data on it. I know you have to be off of zalboraf for a week before any type of radiation. I’d check with the oncologist to see his opinion.
                          L
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