Is it FAMMM?

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  • Post
    • March 31, 2016 at 9:54 pm
    fabiopinto_
    Participant

      Hello guys.

       

      I'm worried about something: I have an aunt who's had melanoma. She has quite a number of moles on her body. So does my father and grandmother (between 50 and 100), but none of them had the disease.

      Although, my sibling and I have very few moles on our bodies, so I'd like to know if any of us should worry about FAMMM, CDKN2A mutation or pancreatic cancer risk.

      Thank you!

    Viewing 2 reply threads
    • Replies
        • April 1, 2016 at 12:02 am
        Janner
        Participant

          I'd say no.  I have the mutation and in order to even be in the clinical study I was in, you had to have 3 people in 3 generations with melanoma.  One aunt wouldn't begin to qualify you for that study or indicate you are remotely at risk for that defect.  The defect doesn't skip generations and typically you see a very strong family history.

          • April 1, 2016 at 12:02 am
          Janner
          Participant

            I'd say no.  I have the mutation and in order to even be in the clinical study I was in, you had to have 3 people in 3 generations with melanoma.  One aunt wouldn't begin to qualify you for that study or indicate you are remotely at risk for that defect.  The defect doesn't skip generations and typically you see a very strong family history.

              • April 1, 2016 at 12:33 am
              fabiopinto_
              Participant

                Even if my dad and grandmother (past generation) have those moles too? I'm mostly concerned about that CDKN2A gene or pancreatic cancer.

                • April 1, 2016 at 12:33 am
                fabiopinto_
                Participant

                  Even if my dad and grandmother (past generation) have those moles too? I'm mostly concerned about that CDKN2A gene or pancreatic cancer.

                  • April 1, 2016 at 12:41 am
                  fabiopinto_
                  Participant

                    PS.: none of the 2 of my grandmother's siblings have had melanoam or anything.

                    • April 1, 2016 at 12:41 am
                    fabiopinto_
                    Participant

                      PS.: none of the 2 of my grandmother's siblings have had melanoam or anything.

                      • April 1, 2016 at 12:41 am
                      fabiopinto_
                      Participant

                        PS.: none of the 2 of my grandmother's siblings have had melanoam or anything.

                        • April 1, 2016 at 2:21 am
                        Janner
                        Participant

                          It doesn't matter what moles they have or had – lots or little, not an issue.  They have to be DIAGNOSED WITH MELANOMA.  Having moles isn't the criteria.  Melanoma isn't just sitting around, if a mole changes into melanoma, it is going to continue to grow and spread.  Static moles aren't a problem.  Having melanoma in EVERY generation multiple times is.  And yes, I am talking about CDKN2A.  As I said, I have this genetic defect.  If you can't come up with 3 family members with melanoma, or if you haven't had multiple melanoma primaries, or you do not have a strong family history of pancreatic cancer, you do not have CDKN2A.  You don't have even the most basic criteria for this defect.  It only occurs in a very small melanoma population and having one aunt does not put you at high risk. Without a strong family history of melanoma (or pancreatic cancer), this isn't something you should be worried about. 

                          • April 1, 2016 at 2:21 am
                          Janner
                          Participant

                            It doesn't matter what moles they have or had – lots or little, not an issue.  They have to be DIAGNOSED WITH MELANOMA.  Having moles isn't the criteria.  Melanoma isn't just sitting around, if a mole changes into melanoma, it is going to continue to grow and spread.  Static moles aren't a problem.  Having melanoma in EVERY generation multiple times is.  And yes, I am talking about CDKN2A.  As I said, I have this genetic defect.  If you can't come up with 3 family members with melanoma, or if you haven't had multiple melanoma primaries, or you do not have a strong family history of pancreatic cancer, you do not have CDKN2A.  You don't have even the most basic criteria for this defect.  It only occurs in a very small melanoma population and having one aunt does not put you at high risk. Without a strong family history of melanoma (or pancreatic cancer), this isn't something you should be worried about. 

                            • April 1, 2016 at 9:37 pm
                            fabiopinto_
                            Participant

                              Thank you for the answer 🙂 But most websites said 50+ moles and a family history were enough criteria for the familial annomaly (it's also said the chances may be around 30% instead of higher), I'm confused as hell. What if another person may be eventually getting melanoma? Don't want my family to be at risk for this.

                              • April 1, 2016 at 9:37 pm
                              fabiopinto_
                              Participant

                                Thank you for the answer 🙂 But most websites said 50+ moles and a family history were enough criteria for the familial annomaly (it's also said the chances may be around 30% instead of higher), I'm confused as hell. What if another person may be eventually getting melanoma? Don't want my family to be at risk for this.

                                • April 1, 2016 at 10:56 pm
                                Janner
                                Participant

                                  Most people with dysplastic Nevus syndrome have hundreds of very atypical looking moles.  Not 50, not 100, MANY more moles.  Families who have this defect KNOW about the defect because melanoma is VERY prevalent in their family.  This is not your family.  If you choose to think you have this, nothing I can say will obviously change that.  Go spend the money to get tested and speak with a genetic counselor about your situation.

                                  • April 1, 2016 at 10:56 pm
                                  Janner
                                  Participant

                                    Most people with dysplastic Nevus syndrome have hundreds of very atypical looking moles.  Not 50, not 100, MANY more moles.  Families who have this defect KNOW about the defect because melanoma is VERY prevalent in their family.  This is not your family.  If you choose to think you have this, nothing I can say will obviously change that.  Go spend the money to get tested and speak with a genetic counselor about your situation.

                                    • April 1, 2016 at 10:56 pm
                                    Janner
                                    Participant

                                      Most people with dysplastic Nevus syndrome have hundreds of very atypical looking moles.  Not 50, not 100, MANY more moles.  Families who have this defect KNOW about the defect because melanoma is VERY prevalent in their family.  This is not your family.  If you choose to think you have this, nothing I can say will obviously change that.  Go spend the money to get tested and speak with a genetic counselor about your situation.

                                      • April 8, 2016 at 9:53 pm
                                      fabiopinto_
                                      Participant

                                        Ok, but are there any other characteristics that can be associated with CDKN2A?

                                        • April 8, 2016 at 9:53 pm
                                        fabiopinto_
                                        Participant

                                          Ok, but are there any other characteristics that can be associated with CDKN2A?

                                          • April 8, 2016 at 9:53 pm
                                          fabiopinto_
                                          Participant

                                            Ok, but are there any other characteristics that can be associated with CDKN2A?

                                            • April 1, 2016 at 9:37 pm
                                            fabiopinto_
                                            Participant

                                              Thank you for the answer 🙂 But most websites said 50+ moles and a family history were enough criteria for the familial annomaly (it's also said the chances may be around 30% instead of higher), I'm confused as hell. What if another person may be eventually getting melanoma? Don't want my family to be at risk for this.

                                              • April 1, 2016 at 2:21 am
                                              Janner
                                              Participant

                                                It doesn't matter what moles they have or had – lots or little, not an issue.  They have to be DIAGNOSED WITH MELANOMA.  Having moles isn't the criteria.  Melanoma isn't just sitting around, if a mole changes into melanoma, it is going to continue to grow and spread.  Static moles aren't a problem.  Having melanoma in EVERY generation multiple times is.  And yes, I am talking about CDKN2A.  As I said, I have this genetic defect.  If you can't come up with 3 family members with melanoma, or if you haven't had multiple melanoma primaries, or you do not have a strong family history of pancreatic cancer, you do not have CDKN2A.  You don't have even the most basic criteria for this defect.  It only occurs in a very small melanoma population and having one aunt does not put you at high risk. Without a strong family history of melanoma (or pancreatic cancer), this isn't something you should be worried about. 

                                                • April 1, 2016 at 12:33 am
                                                fabiopinto_
                                                Participant

                                                  Even if my dad and grandmother (past generation) have those moles too? I'm mostly concerned about that CDKN2A gene or pancreatic cancer.

                                                • April 1, 2016 at 12:02 am
                                                Janner
                                                Participant

                                                  I'd say no.  I have the mutation and in order to even be in the clinical study I was in, you had to have 3 people in 3 generations with melanoma.  One aunt wouldn't begin to qualify you for that study or indicate you are remotely at risk for that defect.  The defect doesn't skip generations and typically you see a very strong family history.

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