Ipi+Zelboraf = liver toxicity

› Forums › General Melanoma Community › Ipi+Zelboraf = liver toxicity

  • Post
    • December 18, 2012 at 6:19 pm
    awillett1991
    Participant
      According to my Dr, some of the Ipi+zelboraf trials are shutting down because of liver toxicity issues. The liver just can’t handle both drugs at once. This is where I am now. I finished Ipi #4, 2 weeks ago but after round 3 had to restart Zel because my heart met was growing like crazy. Have already had to stop Zel twice because of crippling side effects even though I was doing really well on it before Ipi.

      At one point my ALP was almost 700, AST, ALT, and bilirubin were all high, but as of yesterday, ALP is down to 352, bili is normal, and the rest isnt too bad. I’m restarting Zel later in the week – I have to take it, but I’m a little gun shy. We are trying to get me to one week on/ one week off the drug. It’s a scary place to be.

      Amy

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    • Replies
        • December 19, 2012 at 12:39 am
        NYKaren
        Participant
          Wow Amy, you certainly have been through a lot. It’s funny how some of us react so differently to these Meds.
          Some on here have been reporting few Ipi side-effects while I was terribly sick with colitis & adrenal insufficiency.

          I’m sorry the benefits of Z come at such a price for you, and I hope you keep responding to it.

          All the best,
          Karen

            • December 21, 2012 at 5:50 pm
            jayafly
            Participant

              My father has gone through 3 rounds of Ipi, but has stopped due to collitis and other side effects.  He can't take systemic steroids due to a very bad toe (maybe MRSA?) infection.  But he is losing so much weight.  Are there any other successful treatments for collitis?  His doc said mesalamine was contraindicated for someone with melanoma in the liver.

              • December 21, 2012 at 5:50 pm
              jayafly
              Participant

                My father has gone through 3 rounds of Ipi, but has stopped due to collitis and other side effects.  He can't take systemic steroids due to a very bad toe (maybe MRSA?) infection.  But he is losing so much weight.  Are there any other successful treatments for collitis?  His doc said mesalamine was contraindicated for someone with melanoma in the liver.

                • December 21, 2012 at 5:50 pm
                jayafly
                Participant

                  My father has gone through 3 rounds of Ipi, but has stopped due to collitis and other side effects.  He can't take systemic steroids due to a very bad toe (maybe MRSA?) infection.  But he is losing so much weight.  Are there any other successful treatments for collitis?  His doc said mesalamine was contraindicated for someone with melanoma in the liver.

                • December 19, 2012 at 12:39 am
                NYKaren
                Participant
                  Wow Amy, you certainly have been through a lot. It’s funny how some of us react so differently to these Meds.
                  Some on here have been reporting few Ipi side-effects while I was terribly sick with colitis & adrenal insufficiency.

                  I’m sorry the benefits of Z come at such a price for you, and I hope you keep responding to it.

                  All the best,
                  Karen

                  • December 19, 2012 at 12:39 am
                  NYKaren
                  Participant
                    Wow Amy, you certainly have been through a lot. It’s funny how some of us react so differently to these Meds.
                    Some on here have been reporting few Ipi side-effects while I was terribly sick with colitis & adrenal insufficiency.

                    I’m sorry the benefits of Z come at such a price for you, and I hope you keep responding to it.

                    All the best,
                    Karen

                    • December 19, 2012 at 6:51 am
                    POW
                    Participant

                      Thanks for the info, Amy. I guess that's the purpose of clinical trials– some ideas are great ideas but they just don't work as expected. I have high hopes for you, though, with your alternating on/off Zelboraf experiment!

                      • December 19, 2012 at 6:51 am
                      POW
                      Participant

                        Thanks for the info, Amy. I guess that's the purpose of clinical trials– some ideas are great ideas but they just don't work as expected. I have high hopes for you, though, with your alternating on/off Zelboraf experiment!

                        • December 19, 2012 at 6:51 am
                        POW
                        Participant

                          Thanks for the info, Amy. I guess that's the purpose of clinical trials– some ideas are great ideas but they just don't work as expected. I have high hopes for you, though, with your alternating on/off Zelboraf experiment!

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