Ipilimumab plus Dacarbazine for Previously Untreated Metastatic Melanoma

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      • July 20, 2011 at 10:23 pm
      James from Sydney
      Participant

        thanks for that info. I wonder if they will now do a Trial to see if adding Dacarbazine to Ippi makes a difference. This Trial compares Dacarbazine alone with Dacarbazine and  Ippi.

        It would be interesting to see if there was a Trial comparing Dacarbazine alone and Ippi alone to see if the stats were similar to the Trial posted. Maybe they will do Ippi alone vs Ippi and Dacabazine.

        best wishes

        James

        • July 20, 2011 at 10:23 pm
        James from Sydney
        Participant

          thanks for that info. I wonder if they will now do a Trial to see if adding Dacarbazine to Ippi makes a difference. This Trial compares Dacarbazine alone with Dacarbazine and  Ippi.

          It would be interesting to see if there was a Trial comparing Dacarbazine alone and Ippi alone to see if the stats were similar to the Trial posted. Maybe they will do Ippi alone vs Ippi and Dacabazine.

          best wishes

          James

            • July 20, 2011 at 10:40 pm
            jim Breitfeller
            Participant

              James,

              Patients with metastatic melanoma have a poor prognosis with a 5 year survival rate of about 5%1. There are two FDA approved treatments for these patients.

              Dacarbazine has an objective  response rate of approximately 12% with 2-3 % complete responses that are often transient2.

              Interleukin-2 (IL-2) has an objective response rate of approximately 15% with 4-5% durable complete responses3.

              Results of two new experimental agents have recently been reported for the treatment of patients with this disease.

              Ipilimumab, an antibody against the inhibitory lymphocyte receptor, CTLA4, mediated a 3.6 month improvement in median survival with an objective response rate of 7% in 540 patients but only three patients (0.6%) achieved a complete regression4.

               PLX4032, an inhibitor of mutated BRAF, had an objective response rate of 77% in 48 patients with 3 (6%) complete regressions5.

              The very small number of durable complete responses make it unlikely that many patients with metastatic melanoma will be cured utilizing any of these approaches.

              This is why we must try combinatorial Therapy

               

              Jimmy B

              • July 20, 2011 at 10:40 pm
              jim Breitfeller
              Participant

                James,

                Patients with metastatic melanoma have a poor prognosis with a 5 year survival rate of about 5%1. There are two FDA approved treatments for these patients.

                Dacarbazine has an objective  response rate of approximately 12% with 2-3 % complete responses that are often transient2.

                Interleukin-2 (IL-2) has an objective response rate of approximately 15% with 4-5% durable complete responses3.

                Results of two new experimental agents have recently been reported for the treatment of patients with this disease.

                Ipilimumab, an antibody against the inhibitory lymphocyte receptor, CTLA4, mediated a 3.6 month improvement in median survival with an objective response rate of 7% in 540 patients but only three patients (0.6%) achieved a complete regression4.

                 PLX4032, an inhibitor of mutated BRAF, had an objective response rate of 77% in 48 patients with 3 (6%) complete regressions5.

                The very small number of durable complete responses make it unlikely that many patients with metastatic melanoma will be cured utilizing any of these approaches.

                This is why we must try combinatorial Therapy

                 

                Jimmy B

                • July 20, 2011 at 11:07 pm
                James from Sydney
                Participant

                  Jimmy thanks for the Stats. I was surprised at the Ippi figures i had thought it was much higher.

                  best wishes

                  James

                  • July 20, 2011 at 11:07 pm
                  James from Sydney
                  Participant

                    Jimmy thanks for the Stats. I was surprised at the Ippi figures i had thought it was much higher.

                    best wishes

                    James

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