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JerryfromFauq.
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- August 20, 2013 at 2:34 am
Review August 15, 2013Immunotherapy and the Concept of a Clinical Cure
Eur. J. Cancer 2013 Jul 25;[EPub Ahead of Print], AM Eggermont, G Kroemer, L Zitvogel
Review August 15, 2013Immunotherapy and the Concept of a Clinical Cure
Eur. J. Cancer 2013 Jul 25;[EPub Ahead of Print], AM Eggermont, G Kroemer, L Zitvogel
TAKE-HOME MESSAGE
The authors discuss their thoughts on the optimal way to continue the renaissance in cancer immunotherapy with the ultimate goal of achieving a complete cure for patients.
ABSTRACT
Immunotherapy has entered a new phase in its history, i.e. the phase of being broadly accepted as a key component of therapeutic strategies to control and cure cancer. Immune-modulation by checkpoint inhibitors have demonstrated to be capable of inducing long lasting tumour responses. Breaking tolerance by ipilimumab has been a crucial event in the past recent years, but PD-1/PD-L1 antibodies have forever changed the landscape in oncology in 2013. The most mature results have been obtained in advanced melanoma patients. High response rates of high quality with prolonged duration have been demonstrated in melanoma, renal cancer and in lung cancer. The broad potential is now being explored across a wide range of tumours. Importantly, synergy with ipilimumab has been demonstrated in melanoma, indicating a bright further future. Long term tumour control now seems achievable and thus the concept of a "clinical cure" is emerging. These antibodies bring immunotherapy to the forefront and indicate that immune-modulation will be a key component of therapeutic strategies from now on. All these observations indicate that "clinical cures" can only be achieved when the immune system is involved, and so the true renaissance of immunotherapy has arrived.
European Journal of CancerImmunotherapy and the Concept of a Clinical Cure
Eur. J. Cancer 2013 Jul 25;[EPub Ahead of Print], AM Eggermont, G Kroemer, L Zitvogel
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- August 20, 2013 at 1:58 pm
Funny how old ideas come around again– or find broader applications with time.
I remember many years ago when a famous epidemiologist blew my mind by telling me that neither antibiotics nor vaccines actually "cure" infectious diseases or prevent their spread. Huh?! What?! He said that the only thing that really cures or prevents the spread of such diseases is the immune system. Antibiotics can dampen down the infection long enough for the immune system to get rid of it completely. Vaccines can stimulate and "train" the immune system to attack the disease more aggressively. But the bottom line in all cases is the human immune system itself.
Maybe, just maybe, science is getting to the point of treating (i.e., controlling) cancer the way they got a handle on infectious diseases 50 years ago. Wouldn't that be wonderful?!
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- August 20, 2013 at 1:58 pm
Funny how old ideas come around again– or find broader applications with time.
I remember many years ago when a famous epidemiologist blew my mind by telling me that neither antibiotics nor vaccines actually "cure" infectious diseases or prevent their spread. Huh?! What?! He said that the only thing that really cures or prevents the spread of such diseases is the immune system. Antibiotics can dampen down the infection long enough for the immune system to get rid of it completely. Vaccines can stimulate and "train" the immune system to attack the disease more aggressively. But the bottom line in all cases is the human immune system itself.
Maybe, just maybe, science is getting to the point of treating (i.e., controlling) cancer the way they got a handle on infectious diseases 50 years ago. Wouldn't that be wonderful?!
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- August 20, 2013 at 1:58 pm
Funny how old ideas come around again– or find broader applications with time.
I remember many years ago when a famous epidemiologist blew my mind by telling me that neither antibiotics nor vaccines actually "cure" infectious diseases or prevent their spread. Huh?! What?! He said that the only thing that really cures or prevents the spread of such diseases is the immune system. Antibiotics can dampen down the infection long enough for the immune system to get rid of it completely. Vaccines can stimulate and "train" the immune system to attack the disease more aggressively. But the bottom line in all cases is the human immune system itself.
Maybe, just maybe, science is getting to the point of treating (i.e., controlling) cancer the way they got a handle on infectious diseases 50 years ago. Wouldn't that be wonderful?!
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- August 20, 2013 at 6:55 pm
POW, Read Gabe Mirkin, That's why he is even in favor of , for certain problems, using low level antibiotics like doxyctrine for long terms.treatments of some things that took a long time to build up in our bodies, like some forms of arthritis and COPD. That class of antibiotics doesn't claim to really kill , it just greatly slows down or even stops reproduction. It's up to the immune system to finish the job then.
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- August 20, 2013 at 6:55 pm
POW, Read Gabe Mirkin, That's why he is even in favor of , for certain problems, using low level antibiotics like doxyctrine for long terms.treatments of some things that took a long time to build up in our bodies, like some forms of arthritis and COPD. That class of antibiotics doesn't claim to really kill , it just greatly slows down or even stops reproduction. It's up to the immune system to finish the job then.
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- August 20, 2013 at 6:55 pm
POW, Read Gabe Mirkin, That's why he is even in favor of , for certain problems, using low level antibiotics like doxyctrine for long terms.treatments of some things that took a long time to build up in our bodies, like some forms of arthritis and COPD. That class of antibiotics doesn't claim to really kill , it just greatly slows down or even stops reproduction. It's up to the immune system to finish the job then.
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