HELP

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    • July 25, 2012 at 1:25 am
    bikerwife
    Participant
      Has anyone had gamma knife more than once. We had it in feb for 5 mets and they are gone. We have 2 new ones that will be gamma knifed on aug 13and I’m scared of having this procedure done again. Our dr told me to stop worrying that they got them the first time and can get them again. I do feel kinda at ease about.

      Also he’s still taking zelobraf which is working wonderful all tumors we could see are almost gone. Why doesn’t it work in brain.

      Thanks for the help

      Has anyone had gamma knife more than once. We had it in feb for 5 mets and they are gone. We have 2 new ones that will be gamma knifed on aug 13and I’m scared of having this procedure done again. Our dr told me to stop worrying that they got them the first time and can get them again. I do feel kinda at ease about.

      Also he’s still taking zelobraf which is working wonderful all tumors we could see are almost gone. Why doesn’t it work in brain.

      Thanks for the help

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    • Replies
        • July 25, 2012 at 2:56 am
        MichaelFL
        Participant

          I can't answer your question about Gamma knife, but I believe Zelboraf does not cross what is called the Blood Brain Barrier (BBB).

          The blood–brain barrier (BBB) is a separation of circulating blood from the brain. Only certain small molecules can cross it. The molecules of Zelboraf are too big.

          • July 25, 2012 at 2:56 am
          MichaelFL
          Participant

            I can't answer your question about Gamma knife, but I believe Zelboraf does not cross what is called the Blood Brain Barrier (BBB).

            The blood–brain barrier (BBB) is a separation of circulating blood from the brain. Only certain small molecules can cross it. The molecules of Zelboraf are too big.

            • July 25, 2012 at 2:56 am
            MichaelFL
            Participant

              I can't answer your question about Gamma knife, but I believe Zelboraf does not cross what is called the Blood Brain Barrier (BBB).

              The blood–brain barrier (BBB) is a separation of circulating blood from the brain. Only certain small molecules can cross it. The molecules of Zelboraf are too big.

              • July 25, 2012 at 4:11 am
              James from Sydney
              Participant

                Ask your Doc to review new data released on Dabrafenib another BRAF drug apparently it has shown positive results with Brain Mets. Here is the link

                http://www.reuters.com/article/2012/05/18/us-melanoma-gsk-dabrafenib-idUSBRE84H01G20120518

                best wishes

                James

                • July 25, 2012 at 4:11 am
                James from Sydney
                Participant

                  Ask your Doc to review new data released on Dabrafenib another BRAF drug apparently it has shown positive results with Brain Mets. Here is the link

                  http://www.reuters.com/article/2012/05/18/us-melanoma-gsk-dabrafenib-idUSBRE84H01G20120518

                  best wishes

                  James

                  • July 25, 2012 at 4:11 am
                  James from Sydney
                  Participant

                    Ask your Doc to review new data released on Dabrafenib another BRAF drug apparently it has shown positive results with Brain Mets. Here is the link

                    http://www.reuters.com/article/2012/05/18/us-melanoma-gsk-dabrafenib-idUSBRE84H01G20120518

                    best wishes

                    James

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