Good News: MEK162/CDK4 trial

This topic has 27 replies, 7 voices, and was last updated 11 years, 2 months ago by FayFighter.

Post

- October 23, 2014 at 2:52 am
- Quote
FayFighter
Participant
I have come to this site for hope countless times. Hoping this post helps someone like you all have helped me. A shout out to Celeste who originally planted the seed regarding this trial.

CT scan today (8 wks out) show 30% reduction in liver lesions.

Thank you.

Angela

Recap re my husbands diagnosis:

july 2010 melanocytic nevi Lower left calf excised (later in 2014 reread by mskcc as melanoma in situ)

derm exams/6 mos

June 2013 small nodules by excision (we had no idea we should be looking for anything like this and thought it was a vericose vein)

July 2013 bump in groin. Biopsy shows it's melanoma.

Mid August 2013 lymphadenectomy (5/19 positive) and excision of lower leg nodules.

oct 2013 start yervoy and gets all 4 cycles. Colon issues require heavy prednisone and 2 remicades.

radiation of lymph basin nov/dec

january 2014 tumor profile NRAS pos BRAF neg

march 2013 finally tapering of prednisone

April 2014 pet shows lesion in stomach (3.5 cm) and little nodule in groin and at lower left calf.

may 21 start anti pd1 and KIR trial.

July 2014 stomach lesion 6cm/liver lesions detected

july 20 surgery to remove stomach lesion

aug 20 start mek162/cdk4 trial liver lesions have shown progression since july

todays scans: liver lesions reduced by 30 percent

Viewing 14 reply threads

Replies

- - October 23, 2014 at 1:42 pm
  - Quote
  tschmith
  Participant
  Love hearing good news! Progress is being made and lots of reason to hope for even more effective treatments.
  
  Hurrah!
  
  Terrie
- - October 23, 2014 at 1:42 pm
  - Quote
  tschmith
  Participant
  Love hearing good news! Progress is being made and lots of reason to hope for even more effective treatments.
  
  Hurrah!
  
  Terrie
- - October 23, 2014 at 1:42 pm
  - Quote
  tschmith
  Participant
  Love hearing good news! Progress is being made and lots of reason to hope for even more effective treatments.
  
  Hurrah!
  
  Terrie
- - October 23, 2014 at 4:26 pm
  - Quote
  arthurjedi007
  Participant
  That sounds wonderful Angela for you and your husband.
  
  Artie
- - October 23, 2014 at 4:26 pm
  - Quote
  arthurjedi007
  Participant
  That sounds wonderful Angela for you and your husband.
  
  Artie
- - October 23, 2014 at 4:26 pm
  - Quote
  arthurjedi007
  Participant
  That sounds wonderful Angela for you and your husband.
  
  Artie
- - October 23, 2014 at 11:04 pm
  - Quote
  Bubbles
  Participant
  Oh, Angela. You made me cry…in the best way ever!!!! 30% reduction in liver lesions at 8 weeks!! That's WONDERFUL! I am so happy for you and your husband! Thanks for sharing with me and everyone else that they may benefit as well. Yours, celeste
  - October 24, 2014 at 2:44 pm
    
    Quote
    ed williams
    Participant
    
    Celeste you have my vote for Melanoma Blogger of the year!!! Keep up the good work. Ed
  - October 24, 2014 at 2:44 pm
    
    Quote
    ed williams
    Participant
    
    Celeste you have my vote for Melanoma Blogger of the year!!! Keep up the good work. Ed
  - October 24, 2014 at 2:44 pm
    
    Quote
    ed williams
    Participant
    
    Celeste you have my vote for Melanoma Blogger of the year!!! Keep up the good work. Ed
- - October 23, 2014 at 11:04 pm
  - Quote
  Bubbles
  Participant
  Oh, Angela. You made me cry…in the best way ever!!!! 30% reduction in liver lesions at 8 weeks!! That's WONDERFUL! I am so happy for you and your husband! Thanks for sharing with me and everyone else that they may benefit as well. Yours, celeste
- - October 23, 2014 at 11:04 pm
  - Quote
  Bubbles
  Participant
  Oh, Angela. You made me cry…in the best way ever!!!! 30% reduction in liver lesions at 8 weeks!! That's WONDERFUL! I am so happy for you and your husband! Thanks for sharing with me and everyone else that they may benefit as well. Yours, celeste
- - October 24, 2014 at 1:46 am
  - Quote
  BrianP
  Participant
  Awesome news Angela. You guys were definitely due for some good news.
  
  Can you list the trial identifier when you get a chance.
  
  Brian
  - October 29, 2014 at 2:26 am
    
    Quote
    FayFighter
    Participant
    
    Hi Brian. And thanks for all your advice/help over the past year. I am so lucky to have found this site.
    
    Novartis CMEK162X2114, version 2 phase 1b. Study of LEE011 with MEK162 in adult pts with NRASmutant melanoma.
  - October 29, 2014 at 2:26 am
    
    Quote
    FayFighter
    Participant
    
    Hi Brian. And thanks for all your advice/help over the past year. I am so lucky to have found this site.
    
    Novartis CMEK162X2114, version 2 phase 1b. Study of LEE011 with MEK162 in adult pts with NRASmutant melanoma.
  - October 29, 2014 at 2:26 am
    
    Quote
    FayFighter
    Participant
    
    Hi Brian. And thanks for all your advice/help over the past year. I am so lucky to have found this site.
    
    Novartis CMEK162X2114, version 2 phase 1b. Study of LEE011 with MEK162 in adult pts with NRASmutant melanoma.
- - October 24, 2014 at 1:46 am
  - Quote
  BrianP
  Participant
  Awesome news Angela. You guys were definitely due for some good news.
  
  Can you list the trial identifier when you get a chance.
  
  Brian
- - October 24, 2014 at 1:46 am
  - Quote
  BrianP
  Participant
  Awesome news Angela. You guys were definitely due for some good news.
  
  Can you list the trial identifier when you get a chance.
  
  Brian
- - October 29, 2014 at 6:14 pm
  - Quote
  kylez
  Participant
  Angela, this must be super encouraging. 30% in 8 weeks. You're a pioneer for NRAS patients like me. It must take some guts and faith to sign up for a trial that's not yet known to have a 'buzz' — like PD1 must have been at its beginning. When I read your news I also thought, sounds like a promising plan B for me too.
  
  I've been able stay in that PD1 / Kir trial. At the 32-week mark (scanned this Monday) the radiologist noted a minimal decrease in size — first time they've seen shrinkage, even if a tiny bit.
  - October 29, 2014 at 6:18 pm
    
    Quote
    kylez
    Participant
    
    I mean, um, your husband's a pioneer! (and you with him).
  - October 30, 2014 at 12:58 am
    
    Quote
    FayFighter
    Participant
    
    Kyle,
    
    In the car with Mike (my husband) and your post made him smile. Being NRAS is like being the stepchild at times. We are over the moon about his response. (Between me and you) I did my own calculations and I think the reduction is actually greater. I am excited for us but excited for everyone who may benefit some day. Two breathes after we got the results of CT, I asked about others and they said they are happy with the results so far. If could be the CDK4 or the MeK or both. It's just refreshing. I can't believe I am driving to NJ with my sweetheart to Ohio with our two small children to celebrate the wedding of my cousin. It's just fantastic.
    
    Keep us posted on your status. All the best.
    
    Angela
  - October 30, 2014 at 12:58 am
    
    Quote
    FayFighter
    Participant
    
    Kyle,
    
    In the car with Mike (my husband) and your post made him smile. Being NRAS is like being the stepchild at times. We are over the moon about his response. (Between me and you) I did my own calculations and I think the reduction is actually greater. I am excited for us but excited for everyone who may benefit some day. Two breathes after we got the results of CT, I asked about others and they said they are happy with the results so far. If could be the CDK4 or the MeK or both. It's just refreshing. I can't believe I am driving to NJ with my sweetheart to Ohio with our two small children to celebrate the wedding of my cousin. It's just fantastic.
    
    Keep us posted on your status. All the best.
    
    Angela
  - October 30, 2014 at 12:58 am
    
    Quote
    FayFighter
    Participant
    
    Kyle,
    
    In the car with Mike (my husband) and your post made him smile. Being NRAS is like being the stepchild at times. We are over the moon about his response. (Between me and you) I did my own calculations and I think the reduction is actually greater. I am excited for us but excited for everyone who may benefit some day. Two breathes after we got the results of CT, I asked about others and they said they are happy with the results so far. If could be the CDK4 or the MeK or both. It's just refreshing. I can't believe I am driving to NJ with my sweetheart to Ohio with our two small children to celebrate the wedding of my cousin. It's just fantastic.
    
    Keep us posted on your status. All the best.
    
    Angela
  - October 29, 2014 at 6:18 pm
    
    Quote
    kylez
    Participant
    
    I mean, um, your husband's a pioneer! (and you with him).
  - October 29, 2014 at 6:18 pm
    
    Quote
    kylez
    Participant
    
    I mean, um, your husband's a pioneer! (and you with him).
- - October 29, 2014 at 6:14 pm
  - Quote
  kylez
  Participant
  Angela, this must be super encouraging. 30% in 8 weeks. You're a pioneer for NRAS patients like me. It must take some guts and faith to sign up for a trial that's not yet known to have a 'buzz' — like PD1 must have been at its beginning. When I read your news I also thought, sounds like a promising plan B for me too.
  
  I've been able stay in that PD1 / Kir trial. At the 32-week mark (scanned this Monday) the radiologist noted a minimal decrease in size — first time they've seen shrinkage, even if a tiny bit.
- - October 29, 2014 at 6:14 pm
  - Quote
  kylez
  Participant
  Angela, this must be super encouraging. 30% in 8 weeks. You're a pioneer for NRAS patients like me. It must take some guts and faith to sign up for a trial that's not yet known to have a 'buzz' — like PD1 must have been at its beginning. When I read your news I also thought, sounds like a promising plan B for me too.
  
  I've been able stay in that PD1 / Kir trial. At the 32-week mark (scanned this Monday) the radiologist noted a minimal decrease in size — first time they've seen shrinkage, even if a tiny bit.