3 weeks ago I had a check-up PET/CT scan .My manubrium and pubic bone showed a high SUV ( 9.4 and 8.6), I had a chest MRI that confirmed that it was malignant. My cancer was back despite I was successfull last fall with ipi/nivo combo. The doctor wanted me to have a pubic bone biopsy just to be sure before starting any new treatment. It was quite unpleasant and painful ,but it was worth it as it came back negative: no melanoma in my bones. It's an inflammation that triggers the high activity on my scan. Doctor thinks that my immune system (stimulated with ipi/nivo ) is now attacking my bone. I have hypothyroidism and during winter I had severe colitis and high level of liver enzyms.
As I have no pain, doc doesn't want me to take any drug( prednisone……I hate this drug) for my bone. I will see him in July and go through an other PET/CT sacn in August.
I was supposed to start a maintenance phase of nivo or keytruda but as my body is still reacting to nivo/ipi, it is going to be delayed for the future.
Do not hesitate toask for a biopsy. Even if it not pleasant, sometimes the outcome can be positive.
Best,
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