Anyone heard of this type of TIL?

› Forums › General Melanoma Community › Anyone heard of this type of TIL?

  • Post
    • January 7, 2015 at 4:01 pm
    arthurjedi007
    Participant

      My doc said yesterday if my tumor sample tests for a certain h receptor I can do this trial. Apparently only 20 percent of us have it.

      They take the tumor sample and grow the t-cells. Then two days of chemo to wipe out existing t-cells. Not sure If that is the same thing as dropping white blood cells to zero. Then they inject the new t-cells. When it works he said it is fantastic.

      when I said that sounds like the til at nih he said the main difference is how they grow the cells.

      So I dunno if this or the til at nih would be better? Very confusing to me.

      Artie

    Viewing 5 reply threads
    • Replies
        • January 7, 2015 at 4:29 pm
        JoshF
        Participant

          Artie-

           

          This different than getting IL-2 etc…. It's on TIL I'm familiar with. Definitely worth a look…are they testing for the receptor on you?

           

          Josh

          • January 7, 2015 at 4:29 pm
          JoshF
          Participant

            Artie-

             

            This different than getting IL-2 etc…. It's on TIL I'm familiar with. Definitely worth a look…are they testing for the receptor on you?

             

            Josh

              • January 7, 2015 at 7:57 pm
              tschmith
              Participant

                Hi Artie!

                       I've not heard of this version of TIL but it sounds exciting!  My doctors consider the MAGE TCR  therapy I got at NIH as basically a combination therapy since I quickly got Pembro after the NIH trail failed.  While the MAGE TCR  failed, the combo worked well…at least it seems to have so far gotten my melanoma under control.  Where is this trail being done?  Did you get your 12th infusion of Keytruda yesterday?  I hope it was a good day for you. 

                       Keep fighting!   You're in my prayers!

                       Terrie

                • January 7, 2015 at 7:57 pm
                tschmith
                Participant

                  Hi Artie!

                         I've not heard of this version of TIL but it sounds exciting!  My doctors consider the MAGE TCR  therapy I got at NIH as basically a combination therapy since I quickly got Pembro after the NIH trail failed.  While the MAGE TCR  failed, the combo worked well…at least it seems to have so far gotten my melanoma under control.  Where is this trail being done?  Did you get your 12th infusion of Keytruda yesterday?  I hope it was a good day for you. 

                         Keep fighting!   You're in my prayers!

                         Terrie

                  • January 8, 2015 at 1:27 am
                  arthurjedi007
                  Participant

                    Thanks Terrie. Yeah I got dose 12 yesterday. But he says several tumors are still growing so I got to get surgery on shoulder and collar cause he didn't like my radiation idea. It is huge and I'm choking a lot from the collar tumor. Then I got to get into some trial although the pd1 has slowed things way down and wiped out many tumors there's too many still growing. He liked my idea of going to Chicago so we shall see. This t-cell vaccine TIL like thing is in saint Louis. So if I test for it and do it at least it will in my home town. But so few have the receptor they haven't done very many. One thing to consider though is the cells are only for tumors with that receptor. So other tumors might not have it so wouldn't work on them. Thus I'm thinking the nih til could probably be more successful cause they target several things but those things are not specific to my tumor so it's kind of good and bad. I dunno. I'm also still thinking the pd1 anti lag at Chicago. But surgery comes first.

                    Artie

                    • January 8, 2015 at 1:27 am
                    arthurjedi007
                    Participant

                      Thanks Terrie. Yeah I got dose 12 yesterday. But he says several tumors are still growing so I got to get surgery on shoulder and collar cause he didn't like my radiation idea. It is huge and I'm choking a lot from the collar tumor. Then I got to get into some trial although the pd1 has slowed things way down and wiped out many tumors there's too many still growing. He liked my idea of going to Chicago so we shall see. This t-cell vaccine TIL like thing is in saint Louis. So if I test for it and do it at least it will in my home town. But so few have the receptor they haven't done very many. One thing to consider though is the cells are only for tumors with that receptor. So other tumors might not have it so wouldn't work on them. Thus I'm thinking the nih til could probably be more successful cause they target several things but those things are not specific to my tumor so it's kind of good and bad. I dunno. I'm also still thinking the pd1 anti lag at Chicago. But surgery comes first.

                      Artie

                      • January 8, 2015 at 1:27 am
                      arthurjedi007
                      Participant

                        Thanks Terrie. Yeah I got dose 12 yesterday. But he says several tumors are still growing so I got to get surgery on shoulder and collar cause he didn't like my radiation idea. It is huge and I'm choking a lot from the collar tumor. Then I got to get into some trial although the pd1 has slowed things way down and wiped out many tumors there's too many still growing. He liked my idea of going to Chicago so we shall see. This t-cell vaccine TIL like thing is in saint Louis. So if I test for it and do it at least it will in my home town. But so few have the receptor they haven't done very many. One thing to consider though is the cells are only for tumors with that receptor. So other tumors might not have it so wouldn't work on them. Thus I'm thinking the nih til could probably be more successful cause they target several things but those things are not specific to my tumor so it's kind of good and bad. I dunno. I'm also still thinking the pd1 anti lag at Chicago. But surgery comes first.

                        Artie

                        • January 7, 2015 at 7:57 pm
                        tschmith
                        Participant

                          Hi Artie!

                                 I've not heard of this version of TIL but it sounds exciting!  My doctors consider the MAGE TCR  therapy I got at NIH as basically a combination therapy since I quickly got Pembro after the NIH trail failed.  While the MAGE TCR  failed, the combo worked well…at least it seems to have so far gotten my melanoma under control.  Where is this trail being done?  Did you get your 12th infusion of Keytruda yesterday?  I hope it was a good day for you. 

                                 Keep fighting!   You're in my prayers!

                                 Terrie

                          • January 8, 2015 at 1:15 am
                          arthurjedi007
                          Participant

                            Thanks Josh. It'll be a few weeks cause their planning to do surgery on my shoulder and I assume collar tumors. Basically at best to take out as much as they safely can. At worse just enough for a sample. Dunno yet. But yeah they'll test for that specific receptor. He doesn't expect I'll have it cause so few do. Also it's a phase one trial that hasn't worked often. But when it did it was fantastic.

                            Artie

                            • January 8, 2015 at 1:15 am
                            arthurjedi007
                            Participant

                              Thanks Josh. It'll be a few weeks cause their planning to do surgery on my shoulder and I assume collar tumors. Basically at best to take out as much as they safely can. At worse just enough for a sample. Dunno yet. But yeah they'll test for that specific receptor. He doesn't expect I'll have it cause so few do. Also it's a phase one trial that hasn't worked often. But when it did it was fantastic.

                              Artie

                              • January 8, 2015 at 1:15 am
                              arthurjedi007
                              Participant

                                Thanks Josh. It'll be a few weeks cause their planning to do surgery on my shoulder and I assume collar tumors. Basically at best to take out as much as they safely can. At worse just enough for a sample. Dunno yet. But yeah they'll test for that specific receptor. He doesn't expect I'll have it cause so few do. Also it's a phase one trial that hasn't worked often. But when it did it was fantastic.

                                Artie

                              • January 7, 2015 at 4:29 pm
                              JoshF
                              Participant

                                Artie-

                                 

                                This different than getting IL-2 etc…. It's on TIL I'm familiar with. Definitely worth a look…are they testing for the receptor on you?

                                 

                                Josh

                                • January 8, 2015 at 3:43 am
                                _Paul_
                                Participant

                                  Oh boy Artie, I am hoping and praying your surgery goes well.

                                  • January 8, 2015 at 3:43 am
                                  _Paul_
                                  Participant

                                    Oh boy Artie, I am hoping and praying your surgery goes well.

                                    • January 8, 2015 at 3:43 am
                                    _Paul_
                                    Participant

                                      Oh boy Artie, I am hoping and praying your surgery goes well.

                                        • January 8, 2015 at 1:22 pm
                                        tschmith
                                        Participant

                                          i hope your surgery goes well too and that you will feel more comfortable afterwards.  They were able to embolize my spinal tumor before they operated, so the blood supply was cut off.  Any chance they could do that for you?  I know it isn't always possible, just wondering.  

                                          You know you're in my prayers!

                                          Terrie

                                          • January 8, 2015 at 1:22 pm
                                          tschmith
                                          Participant

                                            i hope your surgery goes well too and that you will feel more comfortable afterwards.  They were able to embolize my spinal tumor before they operated, so the blood supply was cut off.  Any chance they could do that for you?  I know it isn't always possible, just wondering.  

                                            You know you're in my prayers!

                                            Terrie

                                            • January 8, 2015 at 1:22 pm
                                            tschmith
                                            Participant

                                              i hope your surgery goes well too and that you will feel more comfortable afterwards.  They were able to embolize my spinal tumor before they operated, so the blood supply was cut off.  Any chance they could do that for you?  I know it isn't always possible, just wondering.  

                                              You know you're in my prayers!

                                              Terrie

                                              • January 8, 2015 at 4:04 pm
                                              arthurjedi007
                                              Participant

                                                Thsnks Terrie. Not sure. I know they tried that embolize thing on my spine tumor and couldn't do it so no spine surgery for me so I had to rely on a second radiation to keep from being paralyzed. Dunno much about this shoulder surgery yet except my saint Louis doc wants it and last night I found out my mayo doc thinks I should do radiation instead. So I dunno which doc to listen to.

                                                Artie

                                                • January 8, 2015 at 4:04 pm
                                                arthurjedi007
                                                Participant

                                                  Thsnks Terrie. Not sure. I know they tried that embolize thing on my spine tumor and couldn't do it so no spine surgery for me so I had to rely on a second radiation to keep from being paralyzed. Dunno much about this shoulder surgery yet except my saint Louis doc wants it and last night I found out my mayo doc thinks I should do radiation instead. So I dunno which doc to listen to.

                                                  Artie

                                                  • January 8, 2015 at 4:04 pm
                                                  arthurjedi007
                                                  Participant

                                                    Thsnks Terrie. Not sure. I know they tried that embolize thing on my spine tumor and couldn't do it so no spine surgery for me so I had to rely on a second radiation to keep from being paralyzed. Dunno much about this shoulder surgery yet except my saint Louis doc wants it and last night I found out my mayo doc thinks I should do radiation instead. So I dunno which doc to listen to.

                                                    Artie

                                                    • January 8, 2015 at 3:57 pm
                                                    arthurjedi007
                                                    Participant

                                                      Thanks Psul

                                                      Artie

                                                      • January 8, 2015 at 3:57 pm
                                                      arthurjedi007
                                                      Participant

                                                        Thanks Psul

                                                        Artie

                                                        • January 8, 2015 at 3:57 pm
                                                        arthurjedi007
                                                        Participant

                                                          Thanks Psul

                                                          Artie

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