I know there are a few clinical trials looking into this, but I'm looking for data (even preclinical) regarding whether Melanoma cells are *more* or *less* likely to be recognized by cytotoxic immune cells after BRAF therapy. Has anybody heard of a CR or durable response to PD-1 *after* BRAF inhibition? I've certainly heard the stories of disease coming back "angry" after BRAF therapy (in the minority of patients, of course).
Melanoma experts often discuss the benefit of using BRAF/MEK to decrease tumor burden rapidly in BRAF positive patients with the plan to then swtich to immunotherapy as soon as a decreased burden is attained.
More and more new studies are looking at combining BRAF/MEK with immunotherapy – so we will have to see how that works out….but here is some data out of ASCO last year that demonstrates…YES! Patients who have been treated with BRAFi can respond to "just" anti-PD1 (and this was with brain mets!!!):
Melanoma experts often discuss the benefit of using BRAF/MEK to decrease tumor burden rapidly in BRAF positive patients with the plan to then swtich to immunotherapy as soon as a decreased burden is attained.
More and more new studies are looking at combining BRAF/MEK with immunotherapy – so we will have to see how that works out….but here is some data out of ASCO last year that demonstrates…YES! Patients who have been treated with BRAFi can respond to "just" anti-PD1 (and this was with brain mets!!!):
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