After Activation With Yervoy, IL-2 Produced by Activated CD4+ T Cells Helps CD8+ T-cell Activation

› Forums › General Melanoma Community › After Activation With Yervoy, IL-2 Produced by Activated CD4+ T Cells Helps CD8+ T-cell Activation

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    • July 14, 2011 at 2:00 pm
    jim Breitfeller
    Participant

      After Activation With Yervoy, IL-2 Produced by Activated CD4+ T Cells Helps CD8+ T-cell Activation.

      After Activation With Yervoy, IL-2 Produced by Activated CD4+ T Cells Helps CD8+ T-cell Activation.

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    • Replies
        • July 14, 2011 at 3:41 pm
        killmel
        Participant

          Hi Jim,

           

          I went to your website that has wonderful info but I could not turn off the music.

          How do you turn off the music???

          Maybe you can make the "turn off" music easier to find or maybe leavethe music OFF & people can turn the music ON if they want do.

           

          Thanks

            • July 14, 2011 at 3:57 pm
            jim Breitfeller
            Participant

              After, your comment, I decide to remove the music because it may be distracting while reading the blog entries.

              Thanks for your comment.

              Jimmy B

              • July 14, 2011 at 3:57 pm
              jim Breitfeller
              Participant

                After, your comment, I decide to remove the music because it may be distracting while reading the blog entries.

                Thanks for your comment.

                Jimmy B

              • July 14, 2011 at 3:41 pm
              killmel
              Participant

                Hi Jim,

                 

                I went to your website that has wonderful info but I could not turn off the music.

                How do you turn off the music???

                Maybe you can make the "turn off" music easier to find or maybe leavethe music OFF & people can turn the music ON if they want do.

                 

                Thanks

                • July 15, 2011 at 2:34 am
                Dynasysman
                Participant

                  Jim —

                  This is a great table, packed with information and, given the complexity, quite simple and clear.  It does leave a few questions, though.  What is the source article/document, and where has it been published?  Does it reflect a hypothesis or some kind of study?   And what exactly does it say to you about how to treat melanoma and what patients should be asking their physicians?

                  Thanks.  You share so much with this community and the broader melanoma population…

                  • July 15, 2011 at 2:34 am
                  Dynasysman
                  Participant

                    Jim —

                    This is a great table, packed with information and, given the complexity, quite simple and clear.  It does leave a few questions, though.  What is the source article/document, and where has it been published?  Does it reflect a hypothesis or some kind of study?   And what exactly does it say to you about how to treat melanoma and what patients should be asking their physicians?

                    Thanks.  You share so much with this community and the broader melanoma population…

                      • July 15, 2011 at 12:47 pm
                      jim Breitfeller
                      Participant

                        Dynasysman,

                        The graphic is based on years of research that I have done backed up by research papers from around the world. I spent over three years researching my own treatment that has left me NED. If you look carefully on the graph, I cited some of the papers.

                         

                        It is an excerpt of my paper called "Melanoma and the Magic Bullet (Monoclonal Antibodies"   http://www.box.net/shared/kjgr6dkztj

                        It explains the immune system and scientifically why my treatment worked. It has a references (Research papers) at the end of it. I also wrote another small piece called  

                        "The Making of an Immune Response by Combinatorial Therapy Using   Anti-CTLA-4 Blockade and Interleukin-2"    It is an add on to the other paper.https://www.box.net/shared/n0xcdimy5d 

                        There are other papers also that pertain to our topic  Melanoma/treatment at http://melanomamissionary.blogspot.com/       Melanoma Missionary. 

                        There is a Shared file section at the website with some of reseach papers that I thought might be informative to patients, caregivers, oncologists and researchers. The papers I wrote, I tried to bring the language down to layman terms. I hope this answers your questions. If not  you  can contact me offline at dbreitfe@rochester.rr.com     

                         warm regards  

                        Jimmy B                 

                        • July 15, 2011 at 12:47 pm
                        jim Breitfeller
                        Participant

                          Dynasysman,

                          The graphic is based on years of research that I have done backed up by research papers from around the world. I spent over three years researching my own treatment that has left me NED. If you look carefully on the graph, I cited some of the papers.

                           

                          It is an excerpt of my paper called "Melanoma and the Magic Bullet (Monoclonal Antibodies"   http://www.box.net/shared/kjgr6dkztj

                          It explains the immune system and scientifically why my treatment worked. It has a references (Research papers) at the end of it. I also wrote another small piece called  

                          "The Making of an Immune Response by Combinatorial Therapy Using   Anti-CTLA-4 Blockade and Interleukin-2"    It is an add on to the other paper.https://www.box.net/shared/n0xcdimy5d 

                          There are other papers also that pertain to our topic  Melanoma/treatment at http://melanomamissionary.blogspot.com/       Melanoma Missionary. 

                          There is a Shared file section at the website with some of reseach papers that I thought might be informative to patients, caregivers, oncologists and researchers. The papers I wrote, I tried to bring the language down to layman terms. I hope this answers your questions. If not  you  can contact me offline at dbreitfe@rochester.rr.com     

                           warm regards  

                          Jimmy B                 

                          • July 16, 2011 at 8:56 pm
                          killmel
                          Participant

                            Hi Jimmy,

                             

                            You are a wonderful an to share your insight.

                            I am curious to know what treatment you have done that has helped you remain NED.

                            I looked up ed your profile & could not find the information so I sincerely would appreciate knowing what treatment you have taken.

                            God Bless You

                            Mary

                            • July 16, 2011 at 8:56 pm
                            killmel
                            Participant

                              Hi Jimmy,

                               

                              You are a wonderful an to share your insight.

                              I am curious to know what treatment you have done that has helped you remain NED.

                              I looked up ed your profile & could not find the information so I sincerely would appreciate knowing what treatment you have taken.

                              God Bless You

                              Mary

                              • July 17, 2011 at 1:16 am
                              jim Breitfeller
                              Participant

                                Mary,

                                If you download Melanoma and the Magic bullet paper, My Therapy starts on page 16.

                                Also, as a follow up, I use Off label   

                                Imiquimod is an immune response modifier that increases local cytokine production, with a subsequent activation of both the innate (rapid, nonspecific) and adaptive (specific, cellular, and humoral) immune systems. These characteristics have led to its application in a variety of dermatological conditions. It is sold in 5 % cream.

                                I apply to the primary tumor site every 3 months for about 5 days to activate my immune system.

                                 

                                warm regards

                                Jimmy B

                                 

                                 

                                .

                                • July 17, 2011 at 1:20 am
                                jim Breitfeller
                                Participant

                                   Also, Scientific fact.

                                  Imiquimod induces peripheral monocytes and macrophages to release interferon α and interleukin (IL)-12. Both cytokines promote a cell-mediated immune response led by CD8+ cytotoxic T cells and natural killer cells.

                                  jimmy B

                                  • July 17, 2011 at 4:19 pm
                                  boot2aboot
                                  Participant

                                    Here lies the problem…and it is probably the reason why some treatments work some of the time for some of the people and not all of the people all of the time…each melanoma is different…even in the same person…these little monsters want to live forever and for a few proteins it is remarkable that they seem to outsmart even the smartest researchers not to mention our highly evolved immune systems…so how do researchers solve the mystery on the workings and casting out  of hunderds of disease processes called melanoma? to me, anytime there is a puzzle to solve, sometimes you have to back up and retrace steps…retroactive studies in people who became NED after certain treatments…which to my knowledge hasn't been done…un fracking believable…this is why i am leery of what melanoma experts profess they know…chasing money instead of good basic puzzle solving…now i have to crack my basic high school bio-chemistry text book so i can get myself the best possible odds

                                     

                                    boots

                                    • July 17, 2011 at 4:19 pm
                                    boot2aboot
                                    Participant

                                      Here lies the problem…and it is probably the reason why some treatments work some of the time for some of the people and not all of the people all of the time…each melanoma is different…even in the same person…these little monsters want to live forever and for a few proteins it is remarkable that they seem to outsmart even the smartest researchers not to mention our highly evolved immune systems…so how do researchers solve the mystery on the workings and casting out  of hunderds of disease processes called melanoma? to me, anytime there is a puzzle to solve, sometimes you have to back up and retrace steps…retroactive studies in people who became NED after certain treatments…which to my knowledge hasn't been done…un fracking believable…this is why i am leery of what melanoma experts profess they know…chasing money instead of good basic puzzle solving…now i have to crack my basic high school bio-chemistry text book so i can get myself the best possible odds

                                       

                                      boots

                                      • July 17, 2011 at 1:20 am
                                      jim Breitfeller
                                      Participant

                                         Also, Scientific fact.

                                        Imiquimod induces peripheral monocytes and macrophages to release interferon α and interleukin (IL)-12. Both cytokines promote a cell-mediated immune response led by CD8+ cytotoxic T cells and natural killer cells.

                                        jimmy B

                                        • July 17, 2011 at 1:16 am
                                        jim Breitfeller
                                        Participant

                                          Mary,

                                          If you download Melanoma and the Magic bullet paper, My Therapy starts on page 16.

                                          Also, as a follow up, I use Off label   

                                          Imiquimod is an immune response modifier that increases local cytokine production, with a subsequent activation of both the innate (rapid, nonspecific) and adaptive (specific, cellular, and humoral) immune systems. These characteristics have led to its application in a variety of dermatological conditions. It is sold in 5 % cream.

                                          I apply to the primary tumor site every 3 months for about 5 days to activate my immune system.

                                           

                                          warm regards

                                          Jimmy B

                                           

                                           

                                          .

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