Does new lesion on hip mean Keytruda is no longer working for me ?

Hi Artie,

I dont think so. Occasionaly, it is an "old" tumor that is going through pseudo-progression before it shrinks. Actually most of the tumors on hodi and Wolcok paper:"Guidelines for evaluation of immune therapy.." http://clincancerres.aacrjournals.org/content/15/23/7412 shows growth and than shrinkage (Fig.1)

whishing you all the best,

mom 

Hi Artie,

I dont think so. Occasionaly, it is an "old" tumor that is going through pseudo-progression before it shrinks. Actually most of the tumors on hodi and Wolcok paper:"Guidelines for evaluation of immune therapy.." http://clincancerres.aacrjournals.org/content/15/23/7412 shows growth and than shrinkage (Fig.1)

whishing you all the best,

mom 

Hi Artie,

I dont think so. Occasionaly, it is an "old" tumor that is going through pseudo-progression before it shrinks. Actually most of the tumors on hodi and Wolcok paper:"Guidelines for evaluation of immune therapy.." http://clincancerres.aacrjournals.org/content/15/23/7412 shows growth and than shrinkage (Fig.1)

whishing you all the best,

mom 

Oh, Artie! 

I'm not sure.  I guess Mom is possibly correct, that this is enlargement of not necessarily tumor but infiltrates around it.  However, you have always been proactive and I'd probably be talking to the docs about how they see it and if they think it is time to be looking at the LAG-3 trials, TIL, etc.  I am still holding out for some synergistic effect between your current and upcoming radiation treatments and Keytruda!!!  How is your swallowing?  Are you seeing any improvement there?  Much love, c

Oh, Artie! 

I'm not sure.  I guess Mom is possibly correct, that this is enlargement of not necessarily tumor but infiltrates around it.  However, you have always been proactive and I'd probably be talking to the docs about how they see it and if they think it is time to be looking at the LAG-3 trials, TIL, etc.  I am still holding out for some synergistic effect between your current and upcoming radiation treatments and Keytruda!!!  How is your swallowing?  Are you seeing any improvement there?  Much love, c

Oh, Artie! 

I'm not sure.  I guess Mom is possibly correct, that this is enlargement of not necessarily tumor but infiltrates around it.  However, you have always been proactive and I'd probably be talking to the docs about how they see it and if they think it is time to be looking at the LAG-3 trials, TIL, etc.  I am still holding out for some synergistic effect between your current and upcoming radiation treatments and Keytruda!!!  How is your swallowing?  Are you seeing any improvement there?  Much love, c

Artie-

I certainly hope it doesn't mean it's stopped working. What does onc say? Praying that all goes well with radiation and Keytruda…get some relief on neck tumors etc…

Josh

Artie-

I certainly hope it doesn't mean it's stopped working. What does onc say? Praying that all goes well with radiation and Keytruda…get some relief on neck tumors etc…

Josh

Artie-

I certainly hope it doesn't mean it's stopped working. What does onc say? Praying that all goes well with radiation and Keytruda…get some relief on neck tumors etc…

Josh

Artie, I won't go into all the details of what I already posted earlier today, but from what my dad's oncologist at UCSF said, new tumors or significant growth after starting Keytruda does not bode well. When pushed for a prognosis, he said we're talking months in my dad's case, that he's not at the super advanced stage, but that the doctor wouldn't want to postpone a change in treatment for more than a few weeks. 

However, perhaps the radiation would make the difference in how well the lesion will respond to Keytruda now. I'd think that's very possible and is something to ask your doctor about before switching treatments. 

On another note, with the crisis my dad suffered that day, I didn't have a chance to investigate that trial we had talked about. I will still try, though, as things hopefully continue to improve with Dad. 

Artie, I won't go into all the details of what I already posted earlier today, but from what my dad's oncologist at UCSF said, new tumors or significant growth after starting Keytruda does not bode well. When pushed for a prognosis, he said we're talking months in my dad's case, that he's not at the super advanced stage, but that the doctor wouldn't want to postpone a change in treatment for more than a few weeks. 

However, perhaps the radiation would make the difference in how well the lesion will respond to Keytruda now. I'd think that's very possible and is something to ask your doctor about before switching treatments. 

On another note, with the crisis my dad suffered that day, I didn't have a chance to investigate that trial we had talked about. I will still try, though, as things hopefully continue to improve with Dad. 

Artie, I won't go into all the details of what I already posted earlier today, but from what my dad's oncologist at UCSF said, new tumors or significant growth after starting Keytruda does not bode well. When pushed for a prognosis, he said we're talking months in my dad's case, that he's not at the super advanced stage, but that the doctor wouldn't want to postpone a change in treatment for more than a few weeks. 

However, perhaps the radiation would make the difference in how well the lesion will respond to Keytruda now. I'd think that's very possible and is something to ask your doctor about before switching treatments. 

On another note, with the crisis my dad suffered that day, I didn't have a chance to investigate that trial we had talked about. I will still try, though, as things hopefully continue to improve with Dad.