Dabrafenib & Ipi

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  • Post
    • December 5, 2014 at 10:03 am
    Mat
    Participant

      In 2013, there was a Phase I trial combining dabrafenib and ipi.  (There was also an arm that included mekinist, but it was suspended due to a disproportionate number of patients experiencing colitis.)  As a Phase I trial, the purpose was to test safety and tolerability–but does anyone have a sense for how the patients on this trial are doing?  At one point in the not-so-distant past, folks were very optimistic about this combo.  Thanks.

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    • Replies
        • December 5, 2014 at 2:48 pm
        Bubbles
        Participant

          Hey Mat,

          I haven't seen any particularly  new reports. Here was some preliminary info from ASCO in June (last article):  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/06/ipilimumab-in-combination-with-other.html

          Not sure that helps much…. c

           

          • December 5, 2014 at 2:48 pm
          Bubbles
          Participant

            Hey Mat,

            I haven't seen any particularly  new reports. Here was some preliminary info from ASCO in June (last article):  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/06/ipilimumab-in-combination-with-other.html

            Not sure that helps much…. c

             

            • December 5, 2014 at 2:48 pm
            Bubbles
            Participant

              Hey Mat,

              I haven't seen any particularly  new reports. Here was some preliminary info from ASCO in June (last article):  http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2014/06/ipilimumab-in-combination-with-other.html

              Not sure that helps much…. c

               

              • December 5, 2014 at 3:20 pm
              arthurjedi007
              Participant

                I can't say directly but that was the first medicine treatment they tried to get me into back in July 2013. The trial never happened for me but later I did take ipi then a month later started the combo. I later heard or thought I heard the trial had been cancelled not just no longer recruiting and when I asked why all they would say is it was due to toxicity. What the toxicity affected I dunno. Later I heard they were going to do the trial again but with lower dosages. Since those medicines didn't do much good for me I lost interest in keeping track of it.

                Artie

                 

                • December 5, 2014 at 3:20 pm
                arthurjedi007
                Participant

                  I can't say directly but that was the first medicine treatment they tried to get me into back in July 2013. The trial never happened for me but later I did take ipi then a month later started the combo. I later heard or thought I heard the trial had been cancelled not just no longer recruiting and when I asked why all they would say is it was due to toxicity. What the toxicity affected I dunno. Later I heard they were going to do the trial again but with lower dosages. Since those medicines didn't do much good for me I lost interest in keeping track of it.

                  Artie

                   

                  • December 5, 2014 at 3:20 pm
                  arthurjedi007
                  Participant

                    I can't say directly but that was the first medicine treatment they tried to get me into back in July 2013. The trial never happened for me but later I did take ipi then a month later started the combo. I later heard or thought I heard the trial had been cancelled not just no longer recruiting and when I asked why all they would say is it was due to toxicity. What the toxicity affected I dunno. Later I heard they were going to do the trial again but with lower dosages. Since those medicines didn't do much good for me I lost interest in keeping track of it.

                    Artie

                     

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