I assume the EGFR thing no longer applies to Keytruda?

› Forums › General Melanoma Community › I assume the EGFR thing no longer applies to Keytruda?

  • Post
    • November 21, 2014 at 4:19 pm
    arthurjedi007
    Participant

      I just wanted to make sure that since Keytruda is now FDA approved the EGFR requirement during the trials no longer applies. That's the thing that says if I have to be out and about in a wheelchair then I can't get it because I don't have a EGFR of 0 or 1. Although I can still walk a couple minutes.

      Basically since I can walk across the room ok but to be out and about I need the wheel chair because I can't walk very far I got turned down by NIH. Which that is ok to me I think I would prefer the nivo/antilag trial instead. Fortunately I figured as much so it was just over the phone. I also figured that so I cancelled the Chicago trip.

      But since Keytruda is still working pretty good for me I wanted to make sure I can get my 10th dose Tuesday even not being able to walk too good.

      I checked http://www.cancer.gov/cancertopics/druginfo/pembrolizumab and it doesn't seem to say anything about it so I assume so but I dunno.

      It's weird cause a month ago I was walking 2 miles a day fine. So I dunno what is going on with this leg and hip. Otherwise I'm doing normal for me. I haven't heard from the doc yet except he wanted me in NIH and to hold off on trying to fix the walking so if I don't hear from them over the phone I'll sure hear something when I'm there Tuesday.

      Artie

       

       

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    • Replies
        • November 21, 2014 at 5:09 pm
        RJoeyB
        Participant

          Artie, I'm assuming you mean ECOG Performance Status?

          http://www.ecog.org/general/perf_stat.html

          I know that's what NIH uses.  I don't believe that Keytruda in it's approved form has a stated ECOG PS requirement (other than 5 — do they really have to include that? 😉

          What's the thinking about your leg and hip?  Do they think the spinal mets are causing nerve issues that are affecting your leg and hip?

          Joe

           

          • November 21, 2014 at 5:09 pm
          RJoeyB
          Participant

            Artie, I'm assuming you mean ECOG Performance Status?

            http://www.ecog.org/general/perf_stat.html

            I know that's what NIH uses.  I don't believe that Keytruda in it's approved form has a stated ECOG PS requirement (other than 5 — do they really have to include that? 😉

            What's the thinking about your leg and hip?  Do they think the spinal mets are causing nerve issues that are affecting your leg and hip?

            Joe

             

            • November 21, 2014 at 5:09 pm
            RJoeyB
            Participant

              Artie, I'm assuming you mean ECOG Performance Status?

              http://www.ecog.org/general/perf_stat.html

              I know that's what NIH uses.  I don't believe that Keytruda in it's approved form has a stated ECOG PS requirement (other than 5 — do they really have to include that? 😉

              What's the thinking about your leg and hip?  Do they think the spinal mets are causing nerve issues that are affecting your leg and hip?

              Joe

               

                • November 21, 2014 at 6:02 pm
                arthurjedi007
                Participant

                  Oh yeah. ECOG. Thanks.

                  They haven't really started looking at my leg and hip yet. Other than the 11/3 scan showed a tumor in the end of my tibia bone in my knee the doc thought is what is causing the issue. I guess that could be the whole issue. It is certainly how it started was over a month ago I was doing my mile walk and that left leg suddenly felt odd. So I had to hobble back home. I kept pushing to try to walk and that just seemed to make it worse. Now that I don't walk much I don't get a lot of pain like I was. It could be something with the spine or I also have some in my pelvis too. But yeah right now it's just all speculation except that one in my knee he thought was what is causing the issue. I hope that is all it is. Legs, knees and hips are complicated enough to treat without adding this stupid disease into the mix. 20 or so years ago I had knee issues where the cartilege was almost all gone. Stupid me in college jumping down 5 feet to concrete almost every day to go into a building probably caused that. Back then the surgeon doc wanted physical therapy instead of surgery. It took about 10 years before I could finally walk a mile again but at least it did get better.

                  Artie

                   

                  • November 21, 2014 at 6:02 pm
                  arthurjedi007
                  Participant

                    Oh yeah. ECOG. Thanks.

                    They haven't really started looking at my leg and hip yet. Other than the 11/3 scan showed a tumor in the end of my tibia bone in my knee the doc thought is what is causing the issue. I guess that could be the whole issue. It is certainly how it started was over a month ago I was doing my mile walk and that left leg suddenly felt odd. So I had to hobble back home. I kept pushing to try to walk and that just seemed to make it worse. Now that I don't walk much I don't get a lot of pain like I was. It could be something with the spine or I also have some in my pelvis too. But yeah right now it's just all speculation except that one in my knee he thought was what is causing the issue. I hope that is all it is. Legs, knees and hips are complicated enough to treat without adding this stupid disease into the mix. 20 or so years ago I had knee issues where the cartilege was almost all gone. Stupid me in college jumping down 5 feet to concrete almost every day to go into a building probably caused that. Back then the surgeon doc wanted physical therapy instead of surgery. It took about 10 years before I could finally walk a mile again but at least it did get better.

                    Artie

                     

                    • November 21, 2014 at 6:02 pm
                    arthurjedi007
                    Participant

                      Oh yeah. ECOG. Thanks.

                      They haven't really started looking at my leg and hip yet. Other than the 11/3 scan showed a tumor in the end of my tibia bone in my knee the doc thought is what is causing the issue. I guess that could be the whole issue. It is certainly how it started was over a month ago I was doing my mile walk and that left leg suddenly felt odd. So I had to hobble back home. I kept pushing to try to walk and that just seemed to make it worse. Now that I don't walk much I don't get a lot of pain like I was. It could be something with the spine or I also have some in my pelvis too. But yeah right now it's just all speculation except that one in my knee he thought was what is causing the issue. I hope that is all it is. Legs, knees and hips are complicated enough to treat without adding this stupid disease into the mix. 20 or so years ago I had knee issues where the cartilege was almost all gone. Stupid me in college jumping down 5 feet to concrete almost every day to go into a building probably caused that. Back then the surgeon doc wanted physical therapy instead of surgery. It took about 10 years before I could finally walk a mile again but at least it did get better.

                      Artie

                       

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