› Forums › Cutaneous Melanoma Community › Virus kills melanoma, spares normal cells
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JerryfromFauq.
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- August 10, 2014 at 5:14 am
http://www.sciencedaily.com/releases/2013/04/130423135710.htm
Virus kills melanoma in animal model, spares normal cells
Date: April 23, 2013
Source: American Society for Microbiology
Researchers from Yale University School of Medicine have demonstrated that vesicular stomatitis virus (VSV) is highly competent at finding, infecting, and killing human melanoma cells, both in vitro and in animal models, while having little propensity to infect non-cancerous cells."If it works as well in humans, this could confer a substantial benefit on patients afflicted with this deadly disease," says Anthony van den Pol, a researcher on the study. The research was published online ahead of print in the Journal of Virology.
Most normal cells resist virus infection by activating antiviral processes that protect nearby cells. "The working hypothesis was that since many cancer cells show a deficient ability to withstand virus infection, maybe a fast-acting virus such as VSV would be able to infect and kill cancer cells before the virus was eliminated by the immune system," says van den Pol. And indeed, the virus was able to selectively infect multiple deadly human melanomas that had been implanted in a mouse model, yet showed little infectivity towards normal mouse cells, he says.
Many different mechanisms are involved in innate immunity, the type of immunity that combats viral infection. van den Pol plans to investigate which specific mechanisms are malfunctioning in cancer cells, knowledge that would be hugely beneficial both in understanding how cancer affects immunity, and in enhancing a virus' ability to target cancer cells, he says.
Melanoma is the most deadly skin cancer. Most melanomas are incurable once they have metastasized into the body. The incidence of melanoma has tripled over the last three decades, and it accounts for approximately 75 percent of skin cancer-related deaths.
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- August 10, 2014 at 3:06 pm
Viruses killing melanoma is nothing new. The Latvians already have somewhat of a handle on it with a drug called RIGVIR. http://en.wikipedia.org/wiki/RIGVIR
Latvia is a small country in Europe so people tend to turn their noses up at the drug and its potential. But the thing to remember is that they are treating people with it and it appears to be working.
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- August 10, 2014 at 3:06 pm
Viruses killing melanoma is nothing new. The Latvians already have somewhat of a handle on it with a drug called RIGVIR. http://en.wikipedia.org/wiki/RIGVIR
Latvia is a small country in Europe so people tend to turn their noses up at the drug and its potential. But the thing to remember is that they are treating people with it and it appears to be working.
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- August 10, 2014 at 3:06 pm
Viruses killing melanoma is nothing new. The Latvians already have somewhat of a handle on it with a drug called RIGVIR. http://en.wikipedia.org/wiki/RIGVIR
Latvia is a small country in Europe so people tend to turn their noses up at the drug and its potential. But the thing to remember is that they are treating people with it and it appears to be working.
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- August 10, 2014 at 4:19 pm
In my opinion virotherapy is very encouraging. I hope it becomes as good or better than immunotherapy. I don't know much about it but I read a little bit that at one time immunotherapy (ie: ipi at that time) was looked down on and now it is a mainstream treatment for us. Maybe virotherapy will become that way too.
Here's a recent article on how Mayo cured a ladies blood cancer with the measles vaccine.
http://projectavalon.net/forum4/showthread.php?71493-A-massive-vaccine-dose-cures——Cancer
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- August 11, 2014 at 11:26 pm
Definitely one line of attack to follow. Again, it will be a matter of what will work on an individuals cancer. There is not likely to one virus that can be modified to attack all the different melanomas in all melanoma patients bodies. AS discussed in the Mayo article, If one previously had are was exposed to the measles then it is questionable if this particular virus product would be effective. Another step in the right direction!
The last I read on the Latvia virotherapy was that they don’t have enough money to fund what we want as an acceptable clinical trial! So do they have to sell it to a big drug company to get it to advance? -
- August 11, 2014 at 11:26 pm
Definitely one line of attack to follow. Again, it will be a matter of what will work on an individuals cancer. There is not likely to one virus that can be modified to attack all the different melanomas in all melanoma patients bodies. AS discussed in the Mayo article, If one previously had are was exposed to the measles then it is questionable if this particular virus product would be effective. Another step in the right direction!
The last I read on the Latvia virotherapy was that they don’t have enough money to fund what we want as an acceptable clinical trial! So do they have to sell it to a big drug company to get it to advance? -
- August 12, 2014 at 4:00 pm
I totally agree that it's definitely one line of attack to follow.
From what I can see on RigVir's web site is that they are establishing more and more partnerships throuhout the world. I do remember reading that the developer wanted to keep the product Latvia-centric and was not interested in selling it to a big pharmaceutical company. She passed away in 2010 so that may be the reason behind the light-speed at which these partnerships are being established? To get more funding?
What I find good about RigVir is that the virus has not been genetically modified. Not sure about the one in the article about Mayo.
This entire mode of treatment is a step in the right direction, though. It will be interesting to follow the developments.
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- August 12, 2014 at 4:00 pm
I totally agree that it's definitely one line of attack to follow.
From what I can see on RigVir's web site is that they are establishing more and more partnerships throuhout the world. I do remember reading that the developer wanted to keep the product Latvia-centric and was not interested in selling it to a big pharmaceutical company. She passed away in 2010 so that may be the reason behind the light-speed at which these partnerships are being established? To get more funding?
What I find good about RigVir is that the virus has not been genetically modified. Not sure about the one in the article about Mayo.
This entire mode of treatment is a step in the right direction, though. It will be interesting to follow the developments.
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- August 13, 2014 at 2:35 am
Now if they go public on the Stock market?
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- August 13, 2014 at 2:35 am
Now if they go public on the Stock market?
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- August 13, 2014 at 2:35 am
Now if they go public on the Stock market?
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- August 12, 2014 at 4:00 pm
I totally agree that it's definitely one line of attack to follow.
From what I can see on RigVir's web site is that they are establishing more and more partnerships throuhout the world. I do remember reading that the developer wanted to keep the product Latvia-centric and was not interested in selling it to a big pharmaceutical company. She passed away in 2010 so that may be the reason behind the light-speed at which these partnerships are being established? To get more funding?
What I find good about RigVir is that the virus has not been genetically modified. Not sure about the one in the article about Mayo.
This entire mode of treatment is a step in the right direction, though. It will be interesting to follow the developments.
-
- August 11, 2014 at 11:26 pm
Definitely one line of attack to follow. Again, it will be a matter of what will work on an individuals cancer. There is not likely to one virus that can be modified to attack all the different melanomas in all melanoma patients bodies. AS discussed in the Mayo article, If one previously had are was exposed to the measles then it is questionable if this particular virus product would be effective. Another step in the right direction!
The last I read on the Latvia virotherapy was that they don’t have enough money to fund what we want as an acceptable clinical trial! So do they have to sell it to a big drug company to get it to advance?
-
- August 10, 2014 at 4:19 pm
In my opinion virotherapy is very encouraging. I hope it becomes as good or better than immunotherapy. I don't know much about it but I read a little bit that at one time immunotherapy (ie: ipi at that time) was looked down on and now it is a mainstream treatment for us. Maybe virotherapy will become that way too.
Here's a recent article on how Mayo cured a ladies blood cancer with the measles vaccine.
http://projectavalon.net/forum4/showthread.php?71493-A-massive-vaccine-dose-cures——Cancer
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- August 10, 2014 at 4:19 pm
In my opinion virotherapy is very encouraging. I hope it becomes as good or better than immunotherapy. I don't know much about it but I read a little bit that at one time immunotherapy (ie: ipi at that time) was looked down on and now it is a mainstream treatment for us. Maybe virotherapy will become that way too.
Here's a recent article on how Mayo cured a ladies blood cancer with the measles vaccine.
http://projectavalon.net/forum4/showthread.php?71493-A-massive-vaccine-dose-cures——Cancer
Tagged: cutaneous melanoma
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