any good responder to Ipi or pembro after fail Braf/Mek?

I was only on the combo about 8 weeks. I had already failed zel in 8 weeks. I think mine was already braf resistant before taking these meds. Something about gene mutations and it goes to the erb gene mutation but that is all doc guess work. They never did any gene tests other than the braf. With the combo I think the mekenist helped block all growth except my largest tumor which grew a lot and spread to a lymph node. I doubt if the tafinlar did anything good.

I had to bring the merck eap pd1 to my docs attention. Otherwise my doc was saying the combo was all he had. So yes the folks on this site really help save me. Way more informative than the docs. Otherwise I would have never known about it. But once it opened in Mayo my doc quickly got me in.

Side effects of pembro have been pretty much nothing. I dunno if that is good or bad. I had a week washout from the combo. Then 3 days after my first dose for about 10 days I had grade 1 fevers (100.7 was the highest), massive pressure with the outer edge layer of my skull (where I have tumors) and that was pretty much it I think. So almost 7 weeks with only having to deal with the disease side effects (ie: skull pressure that comes and goes with that visible tumor, shoulder pain from that huge tumor and some spine pain and twinges that comes and goes from those tumors).

I was only on the combo about 8 weeks. I had already failed zel in 8 weeks. I think mine was already braf resistant before taking these meds. Something about gene mutations and it goes to the erb gene mutation but that is all doc guess work. They never did any gene tests other than the braf. With the combo I think the mekenist helped block all growth except my largest tumor which grew a lot and spread to a lymph node. I doubt if the tafinlar did anything good.

I had to bring the merck eap pd1 to my docs attention. Otherwise my doc was saying the combo was all he had. So yes the folks on this site really help save me. Way more informative than the docs. Otherwise I would have never known about it. But once it opened in Mayo my doc quickly got me in.

Side effects of pembro have been pretty much nothing. I dunno if that is good or bad. I had a week washout from the combo. Then 3 days after my first dose for about 10 days I had grade 1 fevers (100.7 was the highest), massive pressure with the outer edge layer of my skull (where I have tumors) and that was pretty much it I think. So almost 7 weeks with only having to deal with the disease side effects (ie: skull pressure that comes and goes with that visible tumor, shoulder pain from that huge tumor and some spine pain and twinges that comes and goes from those tumors).

I was only on the combo about 8 weeks. I had already failed zel in 8 weeks. I think mine was already braf resistant before taking these meds. Something about gene mutations and it goes to the erb gene mutation but that is all doc guess work. They never did any gene tests other than the braf. With the combo I think the mekenist helped block all growth except my largest tumor which grew a lot and spread to a lymph node. I doubt if the tafinlar did anything good.

I had to bring the merck eap pd1 to my docs attention. Otherwise my doc was saying the combo was all he had. So yes the folks on this site really help save me. Way more informative than the docs. Otherwise I would have never known about it. But once it opened in Mayo my doc quickly got me in.

Side effects of pembro have been pretty much nothing. I dunno if that is good or bad. I had a week washout from the combo. Then 3 days after my first dose for about 10 days I had grade 1 fevers (100.7 was the highest), massive pressure with the outer edge layer of my skull (where I have tumors) and that was pretty much it I think. So almost 7 weeks with only having to deal with the disease side effects (ie: skull pressure that comes and goes with that visible tumor, shoulder pain from that huge tumor and some spine pain and twinges that comes and goes from those tumors).