Anyone in this – Phase I trial WB Radiation and Ipi?

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  • Post
    • April 13, 2014 at 2:26 pm
    Rocco
    Participant

      Friend of mine notified me that their family member recently joined our ranks with advanced melanoma – brain and lung mets.  Mentioned that the individual is in the midst of a Phase I trial – Ipi and Whole Brain Radiation. I believe his Ohio based trial (at The James Cancer Center – part of OSU) is part of the National trial # NCT01703507.

      Wondering if anyone out there has gone thru a trial with WB radiation and Ipi?  Any thoughts or experiences to share?

       

      Thanks in advance – and hang in there everyone!

      -Rocco

      Stage IV since 2005, Ipi responder since 2009, NED

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    • Replies
        • April 13, 2014 at 3:09 pm
        G-Samsa
        Participant

          My doctors feel there is credible evidence that radiation therapy  can enhance the effects of immunotherapy in certain individuals.  When I required mid-trial radiation therapy to resolve some bone mets– the Drs were not displeased, since the

          additional treatment was thought to be  a way to rev the engine a bit, yet stay consistent with  the  terms of  the immunotherapy trial.  The feeling I got was that regardless of where the  radiation  was introduced it would have an overall synergistic effect.  Perhaps the trial  relates to this reported phenomenon. There's so much conflicting info about  how effective Ipi is in the brain–hopefully the radiation will energize the immuno-response there and show clear positive results.

          • April 13, 2014 at 3:09 pm
          G-Samsa
          Participant

            My doctors feel there is credible evidence that radiation therapy  can enhance the effects of immunotherapy in certain individuals.  When I required mid-trial radiation therapy to resolve some bone mets– the Drs were not displeased, since the

            additional treatment was thought to be  a way to rev the engine a bit, yet stay consistent with  the  terms of  the immunotherapy trial.  The feeling I got was that regardless of where the  radiation  was introduced it would have an overall synergistic effect.  Perhaps the trial  relates to this reported phenomenon. There's so much conflicting info about  how effective Ipi is in the brain–hopefully the radiation will energize the immuno-response there and show clear positive results.

            • April 13, 2014 at 3:09 pm
            G-Samsa
            Participant

              My doctors feel there is credible evidence that radiation therapy  can enhance the effects of immunotherapy in certain individuals.  When I required mid-trial radiation therapy to resolve some bone mets– the Drs were not displeased, since the

              additional treatment was thought to be  a way to rev the engine a bit, yet stay consistent with  the  terms of  the immunotherapy trial.  The feeling I got was that regardless of where the  radiation  was introduced it would have an overall synergistic effect.  Perhaps the trial  relates to this reported phenomenon. There's so much conflicting info about  how effective Ipi is in the brain–hopefully the radiation will energize the immuno-response there and show clear positive results.

          Viewing 2 reply threads
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