Are there any other options when Tafinlar and Mekinist combo stops being effective?

› Forums › General Melanoma Community › Are there any other options when Tafinlar and Mekinist combo stops being effective?

  • Post
    • December 10, 2013 at 8:15 pm
    zbudimir
    Participant

      Does anyone know of any other options when the disease continues to progress on this combo?

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    • Replies
        • December 10, 2013 at 9:18 pm
        Mat
        Participant

          The GSK combo is my initial treatment after diagnosis in July 2013 (heavy tumor burden).  I recall asking the doctors what we would do if it didn't work.  One doctor said chemo and the other said ipi.  However, this was driven by the fact that I had/have a heavy tumor burden.  If you have a lighter burden, you could pursue a clinical tral–PD-1, PD-L1 and ADC seem to be the most talked about options.  Can you share how long you were on the combo before it stopped working and how quickly the disease seems to be progressing once it stopped?

          • December 10, 2013 at 9:18 pm
          Mat
          Participant

            The GSK combo is my initial treatment after diagnosis in July 2013 (heavy tumor burden).  I recall asking the doctors what we would do if it didn't work.  One doctor said chemo and the other said ipi.  However, this was driven by the fact that I had/have a heavy tumor burden.  If you have a lighter burden, you could pursue a clinical tral–PD-1, PD-L1 and ADC seem to be the most talked about options.  Can you share how long you were on the combo before it stopped working and how quickly the disease seems to be progressing once it stopped?

            • December 10, 2013 at 9:18 pm
            Mat
            Participant

              The GSK combo is my initial treatment after diagnosis in July 2013 (heavy tumor burden).  I recall asking the doctors what we would do if it didn't work.  One doctor said chemo and the other said ipi.  However, this was driven by the fact that I had/have a heavy tumor burden.  If you have a lighter burden, you could pursue a clinical tral–PD-1, PD-L1 and ADC seem to be the most talked about options.  Can you share how long you were on the combo before it stopped working and how quickly the disease seems to be progressing once it stopped?

                • December 11, 2013 at 1:30 am
                NYKaren
                Participant

                  Mat, you haven't stopped responding to the combo, have you?  Which doc told you chemo first?  If the ins company approves( fingers crossed) I'll be on the combo too.     Personally, I'd want to stay away from chemo in the hopes of eligibility for a great clinical trial popping up–or, how about we stay stable until pd1 is approved next year!

                  take care,

                  karen

                  • December 11, 2013 at 1:30 am
                  NYKaren
                  Participant

                    Mat, you haven't stopped responding to the combo, have you?  Which doc told you chemo first?  If the ins company approves( fingers crossed) I'll be on the combo too.     Personally, I'd want to stay away from chemo in the hopes of eligibility for a great clinical trial popping up–or, how about we stay stable until pd1 is approved next year!

                    take care,

                    karen

                    • December 11, 2013 at 1:30 am
                    NYKaren
                    Participant

                      Mat, you haven't stopped responding to the combo, have you?  Which doc told you chemo first?  If the ins company approves( fingers crossed) I'll be on the combo too.     Personally, I'd want to stay away from chemo in the hopes of eligibility for a great clinical trial popping up–or, how about we stay stable until pd1 is approved next year!

                      take care,

                      karen

                      • December 11, 2013 at 1:33 am
                      NYKaren
                      Participant

                        Oh boy–I didn't see the original post–I thought it was Mat. 

                        Makes sense now, but I like my idea, let's stay stable!

                        • December 11, 2013 at 1:33 am
                        NYKaren
                        Participant

                          Oh boy–I didn't see the original post–I thought it was Mat. 

                          Makes sense now, but I like my idea, let's stay stable!

                          • December 11, 2013 at 1:33 am
                          NYKaren
                          Participant

                            Oh boy–I didn't see the original post–I thought it was Mat. 

                            Makes sense now, but I like my idea, let's stay stable!

                          • December 11, 2013 at 4:34 am
                          Marialuv
                          Guest

                            Hi dear,
                            my name is Maria am a young girl, it give's me a great pleasure to write you when i saw your profile i became interested in you, If you will have the desire with me so that we can get to know each other and see what happens, i will be very happy if you can write me back through my email address (maria23sankor@yahoo.com) to enable me send you some of my pictures and also introduce my self fully to you.
                            thanks so much and i will be hoping to hear from you soon.
                            Yours new friend, Maria.

                            • December 11, 2013 at 4:34 am
                            Marialuv
                            Guest

                              Hi dear,
                              my name is Maria am a young girl, it give's me a great pleasure to write you when i saw your profile i became interested in you, If you will have the desire with me so that we can get to know each other and see what happens, i will be very happy if you can write me back through my email address (maria23sankor@yahoo.com) to enable me send you some of my pictures and also introduce my self fully to you.
                              thanks so much and i will be hoping to hear from you soon.
                              Yours new friend, Maria.

                              • December 11, 2013 at 4:34 am
                              Marialuv
                              Guest

                                Hi dear,
                                my name is Maria am a young girl, it give's me a great pleasure to write you when i saw your profile i became interested in you, If you will have the desire with me so that we can get to know each other and see what happens, i will be very happy if you can write me back through my email address (maria23sankor@yahoo.com) to enable me send you some of my pictures and also introduce my self fully to you.
                                thanks so much and i will be hoping to hear from you soon.
                                Yours new friend, Maria.

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