Bad News/Possible Good News. Help Needed Please

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  • Post
    • June 6, 2013 at 1:57 am
    NYKaren
    Participant
      So Dr. Wolchok just called to tell me the Merck Phase 1 PD1 trial I was aiming for has been closed by Merck–or at least they’ve closed seats at sloan. He said it was Merck’s edict with no exceptions. Boy am I upset.
      He said my 2 choices are to go back on Zel or see Dr. Pavlick at NYU where they have seats in the phase 2 trial w/the chemo arm.
      I choose to at least see Dr P next week and see what she thinks. I know she’s good, it’s not a matter of that, it’s whether I want to possibly go through the effects of chemo. But I’m afraid if I go back on Zel, the Mel will just come back soon, when there might not be a trial seat available.

      Any ideas, thoughts, suggestions??
      🙁
      Karen

    Viewing 8 reply threads
    • Replies
        • June 6, 2013 at 3:23 am
        kylez
        Participant

          Hi Karen,

          If the phase 2 trial with Dr. Pavlick is the same MK-3475 trial Catherine Poole has discussed over on MIF, (I think it must be), she said it's a 2:1 ration of MK-3475 arm vs. chemo arm, AND that there's some kind of crossover from chemo to MK-3475 if someone is not responding on chemo.

          Hope that helps some.

          – Kyle 

          • June 6, 2013 at 3:23 am
          kylez
          Participant

            Hi Karen,

            If the phase 2 trial with Dr. Pavlick is the same MK-3475 trial Catherine Poole has discussed over on MIF, (I think it must be), she said it's a 2:1 ration of MK-3475 arm vs. chemo arm, AND that there's some kind of crossover from chemo to MK-3475 if someone is not responding on chemo.

            Hope that helps some.

            – Kyle 

            • June 6, 2013 at 3:23 am
            kylez
            Participant

              Hi Karen,

              If the phase 2 trial with Dr. Pavlick is the same MK-3475 trial Catherine Poole has discussed over on MIF, (I think it must be), she said it's a 2:1 ration of MK-3475 arm vs. chemo arm, AND that there's some kind of crossover from chemo to MK-3475 if someone is not responding on chemo.

              Hope that helps some.

              – Kyle 

              • June 6, 2013 at 3:44 am
              POW
              Participant

                O-O-O-F-F-F! What a kick in the stomach! I can't believe the lousy luck you have had with getting into an anti-PD1 trial. I'm so sorry for your disappointment.

                As Kyle said, Catherine Poole at the Melanoma International Foundation keeps really close tabs on all the anti-PD1 trials. She always welcomes people to email her with specific questions. Her email is: cpoole@melanomainternational.org 

                Don't give up! You are worth the effort!

                • June 6, 2013 at 3:44 am
                POW
                Participant

                  O-O-O-F-F-F! What a kick in the stomach! I can't believe the lousy luck you have had with getting into an anti-PD1 trial. I'm so sorry for your disappointment.

                  As Kyle said, Catherine Poole at the Melanoma International Foundation keeps really close tabs on all the anti-PD1 trials. She always welcomes people to email her with specific questions. Her email is: cpoole@melanomainternational.org 

                  Don't give up! You are worth the effort!

                  • June 6, 2013 at 3:44 am
                  POW
                  Participant

                    O-O-O-F-F-F! What a kick in the stomach! I can't believe the lousy luck you have had with getting into an anti-PD1 trial. I'm so sorry for your disappointment.

                    As Kyle said, Catherine Poole at the Melanoma International Foundation keeps really close tabs on all the anti-PD1 trials. She always welcomes people to email her with specific questions. Her email is: cpoole@melanomainternational.org 

                    Don't give up! You are worth the effort!

                    • June 7, 2013 at 1:18 am
                    jag
                    Participant

                      Oh Karen, I am very sorry to hear this.  Is it possible that there are still openings at the other locations?

                      Whatever you decide, You are in my prayers.

                      John

                      http://www.clinicaltrials.gov/ct2/show/NCT01621490?term=melanoma+anti+pd1&rank=2

                      • June 7, 2013 at 1:18 am
                      jag
                      Participant

                        Oh Karen, I am very sorry to hear this.  Is it possible that there are still openings at the other locations?

                        Whatever you decide, You are in my prayers.

                        John

                        http://www.clinicaltrials.gov/ct2/show/NCT01621490?term=melanoma+anti+pd1&rank=2

                        • June 7, 2013 at 1:18 am
                        jag
                        Participant

                          Oh Karen, I am very sorry to hear this.  Is it possible that there are still openings at the other locations?

                          Whatever you decide, You are in my prayers.

                          John

                          http://www.clinicaltrials.gov/ct2/show/NCT01621490?term=melanoma+anti+pd1&rank=2

                          • June 7, 2013 at 7:25 pm
                          NYKaren
                          Participant
                            Thanks guys,
                            Kyle, I think the crossover is allowed at 12 weeks… This stuff is growing fast. I will ask Dr. Pavlick (appt Monday afternoon–that’s impressive) what happens if it is seen to be progressing before then.

                            John, BMS trial excludes prior Remicade use– the stuff that saved me during Ipi-induced colitis.

                            I’ll post after I see Dr. P.
                            have a good weekend all.
                            Karen

                            • June 7, 2013 at 7:25 pm
                            NYKaren
                            Participant
                              Thanks guys,
                              Kyle, I think the crossover is allowed at 12 weeks… This stuff is growing fast. I will ask Dr. Pavlick (appt Monday afternoon–that’s impressive) what happens if it is seen to be progressing before then.

                              John, BMS trial excludes prior Remicade use– the stuff that saved me during Ipi-induced colitis.

                              I’ll post after I see Dr. P.
                              have a good weekend all.
                              Karen

                              • June 7, 2013 at 7:25 pm
                              NYKaren
                              Participant
                                Thanks guys,
                                Kyle, I think the crossover is allowed at 12 weeks… This stuff is growing fast. I will ask Dr. Pavlick (appt Monday afternoon–that’s impressive) what happens if it is seen to be progressing before then.

                                John, BMS trial excludes prior Remicade use– the stuff that saved me during Ipi-induced colitis.

                                I’ll post after I see Dr. P.
                                have a good weekend all.
                                Karen

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