Why fail ipi before getting anti-PD1?

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  • Post
    • February 4, 2013 at 1:01 pm
    POW
    Participant

      My brother's oncologist at Moffitt recently told us that they are no longer accepting patients into their anti-PD1 trials unless and until the patient has tried and failed ipi (Yervoy). Has anyone else heard this? Does anyone know why this should be the case? On the face of it, it seems to be a very odd requirement.

      My brother's oncologist at Moffitt recently told us that they are no longer accepting patients into their anti-PD1 trials unless and until the patient has tried and failed ipi (Yervoy). Has anyone else heard this? Does anyone know why this should be the case? On the face of it, it seems to be a very odd requirement.

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    • Replies
        • February 4, 2013 at 1:37 pm
        awillett1991
        Participant
          I’m no expert, but one trial at Vandy that was opened at the end of the year had two arms, one for prior to Ipi and one for failed Ipi. There are many pages of requirements to get into a trial.

          Maybe those are the only slots left. Have you tried emailing Catherine Poole at MIF? She usually has good inside dirt on PD1 trial openings.

          Have you considered restarting your brother on Zelboraf?

          Best wishes -A

          • February 4, 2013 at 1:37 pm
          awillett1991
          Participant
            I’m no expert, but one trial at Vandy that was opened at the end of the year had two arms, one for prior to Ipi and one for failed Ipi. There are many pages of requirements to get into a trial.

            Maybe those are the only slots left. Have you tried emailing Catherine Poole at MIF? She usually has good inside dirt on PD1 trial openings.

            Have you considered restarting your brother on Zelboraf?

            Best wishes -A

              • February 4, 2013 at 1:51 pm
              POW
              Participant

                Oh. Yeah. That's probably what the doctor meant. The only trial slots available were for people who had already had ipi. That makes sense. Thank you. 

                Yes, I did ask about reintroducing Zelboraf. My brother is officially a patient at the VA and only consults with the oncologists at Moffitt (about clinical trials, for example). Reintroducing Zelboraf is considered to be an "off label" use and the VA prohibits that. So unless some trial starts at Moffitt that tests the effects of intermittent Zelboraf dosing, that is not an option for my brother. 

                • February 4, 2013 at 1:51 pm
                POW
                Participant

                  Oh. Yeah. That's probably what the doctor meant. The only trial slots available were for people who had already had ipi. That makes sense. Thank you. 

                  Yes, I did ask about reintroducing Zelboraf. My brother is officially a patient at the VA and only consults with the oncologists at Moffitt (about clinical trials, for example). Reintroducing Zelboraf is considered to be an "off label" use and the VA prohibits that. So unless some trial starts at Moffitt that tests the effects of intermittent Zelboraf dosing, that is not an option for my brother. 

                  • February 4, 2013 at 1:51 pm
                  POW
                  Participant

                    Oh. Yeah. That's probably what the doctor meant. The only trial slots available were for people who had already had ipi. That makes sense. Thank you. 

                    Yes, I did ask about reintroducing Zelboraf. My brother is officially a patient at the VA and only consults with the oncologists at Moffitt (about clinical trials, for example). Reintroducing Zelboraf is considered to be an "off label" use and the VA prohibits that. So unless some trial starts at Moffitt that tests the effects of intermittent Zelboraf dosing, that is not an option for my brother. 

                    • February 5, 2013 at 3:17 am
                    DeniseK
                    Participant
                      Hi Pat,
                      Just a thought but has your brother applied for social security disability?DDon’t know how it works where you live but that was the only way for me to get medical. It only took 4business days and I had state assistance. I believe its medicaid. This might be an option to get him different medical insurance. Hang in there, I know first hand how frustrating it is.
                      All my best,
                      Denise
                      • February 5, 2013 at 3:17 am
                      DeniseK
                      Participant
                        Hi Pat,
                        Just a thought but has your brother applied for social security disability?DDon’t know how it works where you live but that was the only way for me to get medical. It only took 4business days and I had state assistance. I believe its medicaid. This might be an option to get him different medical insurance. Hang in there, I know first hand how frustrating it is.
                        All my best,
                        Denise
                        • February 5, 2013 at 3:17 am
                        DeniseK
                        Participant
                          Hi Pat,
                          Just a thought but has your brother applied for social security disability?DDon’t know how it works where you live but that was the only way for me to get medical. It only took 4business days and I had state assistance. I believe its medicaid. This might be an option to get him different medical insurance. Hang in there, I know first hand how frustrating it is.
                          All my best,
                          Denise
                          • February 5, 2013 at 3:38 am
                          DeniseK
                          Participant
                            Hi Pat,
                            Just a thought but has your brother applied for social security disability?DDon’t know how it works where you live but that was the only way for me to get medical. It only took 4business days and I had state assistance. I believe its medicaid. This might be an option to get him different medical insurance. Hang in there, I know first hand how frustrating it is.
                            All my best,
                            Denise
                            • February 5, 2013 at 3:38 am
                            DeniseK
                            Participant
                              Hi Pat,
                              Just a thought but has your brother applied for social security disability?DDon’t know how it works where you live but that was the only way for me to get medical. It only took 4business days and I had state assistance. I believe its medicaid. This might be an option to get him different medical insurance. Hang in there, I know first hand how frustrating it is.
                              All my best,
                              Denise
                              • February 5, 2013 at 3:38 am
                              DeniseK
                              Participant
                                Hi Pat,
                                Just a thought but has your brother applied for social security disability?DDon’t know how it works where you live but that was the only way for me to get medical. It only took 4business days and I had state assistance. I believe its medicaid. This might be an option to get him different medical insurance. Hang in there, I know first hand how frustrating it is.
                                All my best,
                                Denise
                              • February 4, 2013 at 1:37 pm
                              awillett1991
                              Participant
                                I’m no expert, but one trial at Vandy that was opened at the end of the year had two arms, one for prior to Ipi and one for failed Ipi. There are many pages of requirements to get into a trial.

                                Maybe those are the only slots left. Have you tried emailing Catherine Poole at MIF? She usually has good inside dirt on PD1 trial openings.

                                Have you considered restarting your brother on Zelboraf?

                                Best wishes -A

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