Monosomy 3 Test Validity?

This topic has 6 replies, 1 voice, and was last updated 13 years, 2 months ago by lak.

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- October 11, 2012 at 12:12 am
- Quote
Chris Jordan
Participant
Saw this in a tweet from @MRFCureOM: http://talkabouthealth.com/can-a-very-large-choroidal-tumor-truly-be-low-risk-if-shown-so-in-monosomy-3-test-result-i-thought-large-usually-meant-high-risk wherein Dr. William Harbour pretty much discounts the genetic test for monosomy 3 in favor of the Class1/2 Castle Biosciences gene expression test.

Saw this in a tweet from @MRFCureOM: http://talkabouthealth.com/can-a-very-large-choroidal-tumor-truly-be-low-risk-if-shown-so-in-monosomy-3-test-result-i-thought-large-usually-meant-high-risk wherein Dr. William Harbour pretty much discounts the genetic test for monosomy 3 in favor of the Class1/2 Castle Biosciences gene expression test. He says, in part, "I do not trust the monosomy 3 test, so I cannot specifically comment on that aspect of the question. The monosomy 3 test is inferior to the Castle Biosciences test that gives a class 1 or class 2 result. All but 2-3 centers in the US are now using it."

I know the two tests were discussed in the June CURE OM web educational event but my question is, does anyone know what Dr Harbour is basing his opinion on? Is there some study that indicates one is a more effective predictor or metastatic OM or is this just a little salesmanship and a case of "not invented here?"

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- - October 11, 2012 at 6:45 am
  - Quote
  lak
  Participant
  I am afraid that I am uncomfortable with this bold statement I also would like reassurances that there are no conflicts of interest between Dr Harbour and the company he advertises.
  
  Its just such a bold statement that does not seem to be well supported by published papers that I have seen.
  
  If any one can send me a link to a paper comparing the 2 processes i would appreicate this.
  
  Lesley
- - October 11, 2012 at 6:45 am
  - Quote
  lak
  Participant
  I am afraid that I am uncomfortable with this bold statement I also would like reassurances that there are no conflicts of interest between Dr Harbour and the company he advertises.
  
  Its just such a bold statement that does not seem to be well supported by published papers that I have seen.
  
  If any one can send me a link to a paper comparing the 2 processes i would appreicate this.
  
  Lesley
  - November 22, 2012 at 9:25 am
    
    Quote
    lak
    Participant
    
    I think if one watches the first Webinair it explains the situatin about genetic testing in a very unbiased and clear supportive way.
  - November 22, 2012 at 9:25 am
    
    Quote
    lak
    Participant
    
    I think if one watches the first Webinair it explains the situatin about genetic testing in a very unbiased and clear supportive way.
  - November 22, 2012 at 9:25 am
    
    Quote
    lak
    Participant
    
    I think if one watches the first Webinair it explains the situatin about genetic testing in a very unbiased and clear supportive way.
- - October 11, 2012 at 6:45 am
  - Quote
  lak
  Participant
  I am afraid that I am uncomfortable with this bold statement I also would like reassurances that there are no conflicts of interest between Dr Harbour and the company he advertises.
  
  Its just such a bold statement that does not seem to be well supported by published papers that I have seen.
  
  If any one can send me a link to a paper comparing the 2 processes i would appreicate this.
  
  Lesley

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