Elevated liver enzymes (Alk Phos, AST, ALT)

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  • Post
    • May 23, 2012 at 6:09 pm
    killmel
    Participant

      Hi,

      I am new to  this forum. Thank God I found all you wonderful warriors.

      I am stage 4 melanoma patients. DX in 2009 and have had multiple surgeries. My first systemic treatment is IPI (yervoy). I just had my 2nd infusion.

      Hi,

      I am new to  this forum. Thank God I found all you wonderful warriors.

      I am stage 4 melanoma patients. DX in 2009 and have had multiple surgeries. My first systemic treatment is IPI (yervoy). I just had my 2nd infusion.

      Yesterday, my blood work showed elevated liver enzymes (Alk Phos, AST, ALT). My doctor told me my liver enzymes (Alk Phos, AST, ALT) were elevated out of the "normal range". He told me that I might not get another IPI infusion because my immune system is causing these liver enzymes to be elevated. I will have my blood tested again in 3 weeks.

      I need your help with information regarding elevated liver enzymes (Alk Phos, AST, ALT).

      Anyone on IPI or any other drug that caused elevated liver enzymes. What happened to your liver (liver enzymes)? Was the drug stopped or did your immune system just stop inflamming/attacking your liver. Did you liver enzymes (Alk Phos, AST, ALT) go back to "normal"

      I am not sure if my liver is permanently damaged (or will become permanently damaged) because of the drug. Is there anything that I can do (perhaps eat certain foods, supplements, ets) to help my liver. I am very worried.

      Thank you so much for taking the time to read my post & to give me any feedback & advice.

      Katherine

       

       

       

    Viewing 5 reply threads
    • Replies
        • May 24, 2012 at 12:01 am
        gabsound
        Participant
          Katherine,

          I had elevated liver enzymes when I was on interferon and when I was on Yervoy. Mine got really high (AST,ALT, alkaline phospatase) by the time I completed Yervoy. I also had mets to the liver so it could also have been due to that. My first post Yervoy scan and labs looked terrible, but the next round showed liver enzymes almost normal and significant improvement on the PET/CT. My Dr was very pleased. I get scans and labs again in a few weeks.

          I know you can also get immune hepatitis from the Yervoy. If you go to the Yervoy website they have all the complications listed. I never felt bad during that time, which my dr thought was a good sign. Hopefully you are feeling well. Is your Dr experienced with Yervoy? Mine is and really didn’t panic about the first scans or the labs.

          Best of luck,

          Julie in Las Vegas

          • May 24, 2012 at 12:01 am
          gabsound
          Participant
            Katherine,

            I had elevated liver enzymes when I was on interferon and when I was on Yervoy. Mine got really high (AST,ALT, alkaline phospatase) by the time I completed Yervoy. I also had mets to the liver so it could also have been due to that. My first post Yervoy scan and labs looked terrible, but the next round showed liver enzymes almost normal and significant improvement on the PET/CT. My Dr was very pleased. I get scans and labs again in a few weeks.

            I know you can also get immune hepatitis from the Yervoy. If you go to the Yervoy website they have all the complications listed. I never felt bad during that time, which my dr thought was a good sign. Hopefully you are feeling well. Is your Dr experienced with Yervoy? Mine is and really didn’t panic about the first scans or the labs.

            Best of luck,

            Julie in Las Vegas

            • May 24, 2012 at 12:01 am
            gabsound
            Participant
              Katherine,

              I had elevated liver enzymes when I was on interferon and when I was on Yervoy. Mine got really high (AST,ALT, alkaline phospatase) by the time I completed Yervoy. I also had mets to the liver so it could also have been due to that. My first post Yervoy scan and labs looked terrible, but the next round showed liver enzymes almost normal and significant improvement on the PET/CT. My Dr was very pleased. I get scans and labs again in a few weeks.

              I know you can also get immune hepatitis from the Yervoy. If you go to the Yervoy website they have all the complications listed. I never felt bad during that time, which my dr thought was a good sign. Hopefully you are feeling well. Is your Dr experienced with Yervoy? Mine is and really didn’t panic about the first scans or the labs.

              Best of luck,

              Julie in Las Vegas

              • May 24, 2012 at 1:13 pm
              Gene_S
              Participant

                My husband had elevated liver enzymes earlier this month and the Dr. warned do not take any tylenol or over the counter drugs that could have tylenol in them as it can cause elevation of the enzymes.  He has been on Yervoy for over a year now but just recently had the higher levels.

                Judy (loving wife and caregiver of Gene)

                • May 24, 2012 at 1:13 pm
                Gene_S
                Participant

                  My husband had elevated liver enzymes earlier this month and the Dr. warned do not take any tylenol or over the counter drugs that could have tylenol in them as it can cause elevation of the enzymes.  He has been on Yervoy for over a year now but just recently had the higher levels.

                  Judy (loving wife and caregiver of Gene)

                  • May 24, 2012 at 1:13 pm
                  Gene_S
                  Participant

                    My husband had elevated liver enzymes earlier this month and the Dr. warned do not take any tylenol or over the counter drugs that could have tylenol in them as it can cause elevation of the enzymes.  He has been on Yervoy for over a year now but just recently had the higher levels.

                    Judy (loving wife and caregiver of Gene)

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