Moving to Vemurafenib/MEK combo after scan results

› Forums › General Melanoma Community › Moving to Vemurafenib/MEK combo after scan results

  • Post
    • March 30, 2012 at 3:37 am
    deardad
    Participant

      Hi everyone,

      Well we got my dads scan results today and it looks like after nearly 7 months Vemurafenib is loosing effectiveness.

      Scans showed 1 x mm increases in the spleen, large lung tumor gone, 4 x liver tumors stable, sub fat x 3 increased by a few mm's. Nothing over 15mm as yet.

      One new growth 10mm in the fat near buttock but hasn't been positively confirmed but I have no doubt that it's Melanoma.

      Hi everyone,

      Well we got my dads scan results today and it looks like after nearly 7 months Vemurafenib is loosing effectiveness.

      Scans showed 1 x mm increases in the spleen, large lung tumor gone, 4 x liver tumors stable, sub fat x 3 increased by a few mm's. Nothing over 15mm as yet.

      One new growth 10mm in the fat near buttock but hasn't been positively confirmed but I have no doubt that it's Melanoma.

      Well we all cried and still feel really sick in the stomach after the trials nurse tells me we need to act quick as the decline can be rapid. Great….

      So dad's oncologist has recommended via the nurse (he is overseas) that dad stay on Vemurafenib until he can get into Roches Vemurafenib/MEK combo (should be within a month). Really scared that maybe the MRI won't be good then what do we do? Hopefully that wont be the case. They don't like you asking many questions, re: treatments, I asked about ANTIPD1 and they don't know much about it but don't believe its running in Australia. Anyone here is AUS that knows whether that's the case? 

      When I asked what plan C is if MEK fails the oncologist said "I can't read the future……" that was very unnerving as well. 

      Any suggestions? Anyone doing well after failing MEK?

      Nahmi

    Viewing 11 reply threads
    • Replies
        • March 30, 2012 at 3:39 am
        deardad
        Participant

          I meant after failing Zelboraf anyone doing well with MEK?

          Thanks in advance

          Nahmi

          • March 30, 2012 at 3:39 am
          deardad
          Participant

            I meant after failing Zelboraf anyone doing well with MEK?

            Thanks in advance

            Nahmi

            • March 30, 2012 at 3:39 am
            deardad
            Participant

              I meant after failing Zelboraf anyone doing well with MEK?

              Thanks in advance

              Nahmi

              • March 30, 2012 at 3:47 am
              James from Sydney
              Participant

                i know a person in Sydney doing really well on the combo for 15 months. I will ask around about PD1 here in Sydney and post if i hear of something.

                best wishes

                James

                  • March 30, 2012 at 4:08 am
                  deardad
                  Participant

                    Hi James thanks for your reply, do you know if this person started on the combo or went from failing braf to the combo BRAF/MEK. Thanks in advance for keeping an eye on PD1 trials.

                    Everyone who contributes to this board are really supportive and wonderful.

                    Thank you

                    Nahmi

                    • March 30, 2012 at 1:18 pm
                    James from Sydney
                    Participant

                      Hi Nahmi, the person i know started with the BRAF / MEK Combo, i will check Monday about PD1 for you. I looked up Melanoma Institute Australia website and they have a E7080 Trial which is another inhibitor, you could always call them and find out about that Trial maybe its available in Melbourne too.

                      cheers

                      James

                      • March 30, 2012 at 1:18 pm
                      James from Sydney
                      Participant

                        Hi Nahmi, the person i know started with the BRAF / MEK Combo, i will check Monday about PD1 for you. I looked up Melanoma Institute Australia website and they have a E7080 Trial which is another inhibitor, you could always call them and find out about that Trial maybe its available in Melbourne too.

                        cheers

                        James

                        • March 30, 2012 at 1:18 pm
                        James from Sydney
                        Participant

                          Hi Nahmi, the person i know started with the BRAF / MEK Combo, i will check Monday about PD1 for you. I looked up Melanoma Institute Australia website and they have a E7080 Trial which is another inhibitor, you could always call them and find out about that Trial maybe its available in Melbourne too.

                          cheers

                          James

                          • March 30, 2012 at 4:08 am
                          deardad
                          Participant

                            Hi James thanks for your reply, do you know if this person started on the combo or went from failing braf to the combo BRAF/MEK. Thanks in advance for keeping an eye on PD1 trials.

                            Everyone who contributes to this board are really supportive and wonderful.

                            Thank you

                            Nahmi

                            • March 30, 2012 at 4:08 am
                            deardad
                            Participant

                              Hi James thanks for your reply, do you know if this person started on the combo or went from failing braf to the combo BRAF/MEK. Thanks in advance for keeping an eye on PD1 trials.

                              Everyone who contributes to this board are really supportive and wonderful.

                              Thank you

                              Nahmi

                            • March 30, 2012 at 3:47 am
                            James from Sydney
                            Participant

                              i know a person in Sydney doing really well on the combo for 15 months. I will ask around about PD1 here in Sydney and post if i hear of something.

                              best wishes

                              James

                              • March 30, 2012 at 3:47 am
                              James from Sydney
                              Participant

                                i know a person in Sydney doing really well on the combo for 15 months. I will ask around about PD1 here in Sydney and post if i hear of something.

                                best wishes

                                James

                                • March 30, 2012 at 5:47 am
                                LynnLuc
                                Participant

                                  I have this link here about B raf/MEK…it looks like the MEK is to control the secondary cancers…but I am no expert on this combo….http://www.cancernetwork.com/melanoma-skin-cancer/content/article/10165/2020914

                                   

                                  but seems that if Braf isn't working why would they consider continuiation of it…with or without MEK.    I am in an anti pd 1 trial (MDX 1106).

                                    • March 30, 2012 at 6:11 am
                                    deardad
                                    Participant

                                      I have no idea, I think Australia is so behind the States, we just don't have the trials you guys have over there. I would love for dad to get into an ANTIPD1 trial but there are currently none here according to the clinic. 

                                      Feeling really flat, I love my dad.

                                      Nahmi

                                      • March 30, 2012 at 1:18 pm
                                      benp
                                      Participant
                                        Hi Nahmi,
                                        Therr is currently a Merck anti pd-1 trial running here (Sydney), though I am told it is closed. I know the frustration of bring behind the US too. I would expect that the trial would be expanded if the results are promising. I’d love to be involved too!
                                        Ben.
                                        • March 30, 2012 at 1:18 pm
                                        benp
                                        Participant
                                          Hi Nahmi,
                                          Therr is currently a Merck anti pd-1 trial running here (Sydney), though I am told it is closed. I know the frustration of bring behind the US too. I would expect that the trial would be expanded if the results are promising. I’d love to be involved too!
                                          Ben.
                                          • March 30, 2012 at 1:18 pm
                                          benp
                                          Participant
                                            Hi Nahmi,
                                            Therr is currently a Merck anti pd-1 trial running here (Sydney), though I am told it is closed. I know the frustration of bring behind the US too. I would expect that the trial would be expanded if the results are promising. I’d love to be involved too!
                                            Ben.
                                            • March 30, 2012 at 6:11 am
                                            deardad
                                            Participant

                                              I have no idea, I think Australia is so behind the States, we just don't have the trials you guys have over there. I would love for dad to get into an ANTIPD1 trial but there are currently none here according to the clinic. 

                                              Feeling really flat, I love my dad.

                                              Nahmi

                                              • March 30, 2012 at 6:11 am
                                              deardad
                                              Participant

                                                I have no idea, I think Australia is so behind the States, we just don't have the trials you guys have over there. I would love for dad to get into an ANTIPD1 trial but there are currently none here according to the clinic. 

                                                Feeling really flat, I love my dad.

                                                Nahmi

                                              • March 30, 2012 at 5:47 am
                                              LynnLuc
                                              Participant

                                                I have this link here about B raf/MEK…it looks like the MEK is to control the secondary cancers…but I am no expert on this combo….http://www.cancernetwork.com/melanoma-skin-cancer/content/article/10165/2020914

                                                 

                                                but seems that if Braf isn't working why would they consider continuiation of it…with or without MEK.    I am in an anti pd 1 trial (MDX 1106).

                                                • March 30, 2012 at 5:47 am
                                                LynnLuc
                                                Participant

                                                  I have this link here about B raf/MEK…it looks like the MEK is to control the secondary cancers…but I am no expert on this combo….http://www.cancernetwork.com/melanoma-skin-cancer/content/article/10165/2020914

                                                   

                                                  but seems that if Braf isn't working why would they consider continuiation of it…with or without MEK.    I am in an anti pd 1 trial (MDX 1106).

                                                  • March 30, 2012 at 2:00 pm
                                                  FormerCaregiver
                                                  Participant

                                                    Nahmi, here are the details of a Novartis PI3K/MEK trial that is apparently available in
                                                    Victoria:
                                                    http://www.clinicaltrials.gov/ct2/show/NCT01337765?term=MEK%2FPI3K+melanoma&rank=2

                                                    Hope this helps

                                                    Frank from Australia

                                                    • March 30, 2012 at 2:00 pm
                                                    FormerCaregiver
                                                    Participant

                                                      Nahmi, here are the details of a Novartis PI3K/MEK trial that is apparently available in
                                                      Victoria:
                                                      http://www.clinicaltrials.gov/ct2/show/NCT01337765?term=MEK%2FPI3K+melanoma&rank=2

                                                      Hope this helps

                                                      Frank from Australia

                                                      • March 30, 2012 at 2:00 pm
                                                      FormerCaregiver
                                                      Participant

                                                        Nahmi, here are the details of a Novartis PI3K/MEK trial that is apparently available in
                                                        Victoria:
                                                        http://www.clinicaltrials.gov/ct2/show/NCT01337765?term=MEK%2FPI3K+melanoma&rank=2

                                                        Hope this helps

                                                        Frank from Australia

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