braf after zelboraf

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  • Post
    boot2aboot
    Participant

      Could anyone on this forum tell me is Mek trial is effective after zelboraf?

      I have read that braf/mek combos are effective treatments.

      Can people still participate in Braf/Mek trials after taking zelboraf?

      Could anyone on this forum tell me is Mek trial is effective after zelboraf?

      I have read that braf/mek combos are effective treatments.

      Can people still participate in Braf/Mek trials after taking zelboraf?

    Viewing 2 reply threads
    • Replies
        deardad
        Participant

          Hi I am also interesting in answers on this topic. My dad is on Zelboraf month 3 and we feel like sitting ducks. The onocologist did mention that we could try MEK next, but I don't know why they didn't just give him the combination in the first place? What is next after Zelboraf or is that the last card? 

          Nahmi from Melbourne

          deardad
          Participant

            Hi I am also interesting in answers on this topic. My dad is on Zelboraf month 3 and we feel like sitting ducks. The onocologist did mention that we could try MEK next, but I don't know why they didn't just give him the combination in the first place? What is next after Zelboraf or is that the last card? 

            Nahmi from Melbourne

              FormerCaregiver
              Participant

                Nahmi, here is a link to the MEK trials in Australia:
                http://www.clinicaltrials.gov/ct2/results?term=melanoma+MEK+Inhibitor&recr=Open&cntry1=PA%3AAU

                Your dad's oncologist is probably hesitant to recommend any new drug that hasn't been
                approved by the TGA. As you may know, Yervoy has recently been approved here and the
                oncologist should be able to tell you how your dad could have access to it.

                Some other viable options could be IL-2 (interleukin-2), TIL treatment (adoptive cell
                therapy) and Anti PD-1 treatment. However, these may be unavailable locally and some may
                only be accessed through clinical trials.

                Therefore, it is important to make definite plans for the next treatment if the current one
                becomes ineffective.

                Hope this helps.

                Frank from Australia

                FormerCaregiver
                Participant

                  Nahmi, here is a link to the MEK trials in Australia:
                  http://www.clinicaltrials.gov/ct2/results?term=melanoma+MEK+Inhibitor&recr=Open&cntry1=PA%3AAU

                  Your dad's oncologist is probably hesitant to recommend any new drug that hasn't been
                  approved by the TGA. As you may know, Yervoy has recently been approved here and the
                  oncologist should be able to tell you how your dad could have access to it.

                  Some other viable options could be IL-2 (interleukin-2), TIL treatment (adoptive cell
                  therapy) and Anti PD-1 treatment. However, these may be unavailable locally and some may
                  only be accessed through clinical trials.

                  Therefore, it is important to make definite plans for the next treatment if the current one
                  becomes ineffective.

                  Hope this helps.

                  Frank from Australia

                  FormerCaregiver
                  Participant

                    Nahmi, here is a link to the MEK trials in Australia:
                    http://www.clinicaltrials.gov/ct2/results?term=melanoma+MEK+Inhibitor&recr=Open&cntry1=PA%3AAU

                    Your dad's oncologist is probably hesitant to recommend any new drug that hasn't been
                    approved by the TGA. As you may know, Yervoy has recently been approved here and the
                    oncologist should be able to tell you how your dad could have access to it.

                    Some other viable options could be IL-2 (interleukin-2), TIL treatment (adoptive cell
                    therapy) and Anti PD-1 treatment. However, these may be unavailable locally and some may
                    only be accessed through clinical trials.

                    Therefore, it is important to make definite plans for the next treatment if the current one
                    becomes ineffective.

                    Hope this helps.

                    Frank from Australia

                    deardad
                    Participant

                      Thanks Frank for posting that, not sure where to go next really. My parents don't want to even talk really about the next treatment until the braf fails. Very frustrating.

                      Nahmi from Melbourne

                      FormerCaregiver
                      Participant

                        Nahmi, I think that you will need to research the treatments for your dad. This will need a lot of work, but I think that it is necessary.

                        The Net makes it easier to find out where various treatments are available. However, you will also have to contact various treatment centres by phone and/or email to get more info.

                        You would also need to ring his oncologist to talk about this. A second opinion could also be an idea.

                        As you might know, I am also located in Melbourne. However, I don't know if that helps at all.

                        Take care

                        Frank from Australia

                        deardad
                        Participant

                          Ok thanks, I will do some research. Im keen to find out about Antipd1 trial if there are any in Australia. I know Jim Stynes who being treated by my dad's oncologist is on this drug. From what I understand TIL requires you to be under the age of 60. I will ask the oncologist about this in 2 weeks. Thanks again.

                          Nahmi

                          deardad
                          Participant

                            Ok thanks, I will do some research. Im keen to find out about Antipd1 trial if there are any in Australia. I know Jim Stynes who being treated by my dad's oncologist is on this drug. From what I understand TIL requires you to be under the age of 60. I will ask the oncologist about this in 2 weeks. Thanks again.

                            Nahmi

                            deardad
                            Participant

                              Ok thanks, I will do some research. Im keen to find out about Antipd1 trial if there are any in Australia. I know Jim Stynes who being treated by my dad's oncologist is on this drug. From what I understand TIL requires you to be under the age of 60. I will ask the oncologist about this in 2 weeks. Thanks again.

                              Nahmi

                              FormerCaregiver
                              Participant

                                Nahmi, I think that you will need to research the treatments for your dad. This will need a lot of work, but I think that it is necessary.

                                The Net makes it easier to find out where various treatments are available. However, you will also have to contact various treatment centres by phone and/or email to get more info.

                                You would also need to ring his oncologist to talk about this. A second opinion could also be an idea.

                                As you might know, I am also located in Melbourne. However, I don't know if that helps at all.

                                Take care

                                Frank from Australia

                                FormerCaregiver
                                Participant

                                  Nahmi, I think that you will need to research the treatments for your dad. This will need a lot of work, but I think that it is necessary.

                                  The Net makes it easier to find out where various treatments are available. However, you will also have to contact various treatment centres by phone and/or email to get more info.

                                  You would also need to ring his oncologist to talk about this. A second opinion could also be an idea.

                                  As you might know, I am also located in Melbourne. However, I don't know if that helps at all.

                                  Take care

                                  Frank from Australia

                                  deardad
                                  Participant

                                    Thanks Frank for posting that, not sure where to go next really. My parents don't want to even talk really about the next treatment until the braf fails. Very frustrating.

                                    Nahmi from Melbourne

                                    deardad
                                    Participant

                                      Thanks Frank for posting that, not sure where to go next really. My parents don't want to even talk really about the next treatment until the braf fails. Very frustrating.

                                      Nahmi from Melbourne

                                    deardad
                                    Participant

                                      Hi I am also interesting in answers on this topic. My dad is on Zelboraf month 3 and we feel like sitting ducks. The onocologist did mention that we could try MEK next, but I don't know why they didn't just give him the combination in the first place? What is next after Zelboraf or is that the last card? 

                                      Nahmi from Melbourne

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