Per package insert, Opdivo (Nivolumab) is dosed at 1mg/kg when combined with ipi (in the ipi/nivo combo) every 3 weeks for 4 doses then followed with a straight dose or 240mg every two weeks. When given alone for melanoma, Opdivo is dosed at 240mg every 2 weeks. I have seen no notation of changes.
Per original package insert Keytruda was dosed at 2mg/kg every three weeks. It comes in 50 mg vials (just so happens). In January Merck made an application to the FDA for a fixed dose of 200mg q 3 weeks, noting something to the effect that this was not substantially different from the dosage most adults were given anyway and alleviate drug waste. At any rate, it appears that change was accepted in May and package inserts revised at that time now note the standard straight dose of 200mg q 3 weeks.
https://www.merck.com/product/usa/pi_circulars/k/keytruda/keytruda_pi.pdf
For what it's worth. Celeste
.
.
