Yervoy and Eye Problems

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  • Post
    • June 15, 2017 at 8:13 pm
    Bmulderbehnia
    Participant

      I am Stage 3B melanoma, recurrence, and in a clinical trial using Yervoy (Ippilimumab) for 3 years.

      I am wondering if anyone else on Yervoy has had problems with their eyes? I've had detachment of the vitreous in both eyes, so lots of floaters (never had this before).

      Most recently, I had a severe reaction to dilation-drops, leaving my eyes painful, watering, light-sensitive, cornea irritation, and light-sensitive in one eye.

      My theory is that it may be related to the Yervoy treatments, since my eye problems started one week after my first treatment.

      The ophthamologist just attributes it to age (I'm 57). I don't buy it.

      Bonny

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    • Replies
        • June 15, 2017 at 8:35 pm
        ed williams
        Participant

          Hi Bonny, your Oncologist is the best person to get help with this!!! Here are some resource for you if you want to read up on Ipi side effects. Best Wishes!!!Ed https://www.hindawi.com/journals/scientifica/2013/857519/  look at section 4.2.5 and for second resource it talks about eyes in section 5.6 https://www.yervoy.com/servlet/servlet.FileDownload?file=00Pi000000TVaZXEA1

            • June 15, 2017 at 8:38 pm
            Bmulderbehnia
            Participant

              Thanks. I have read just about everything there is to read, and discussed it with my oncologist.
              Not looking for expertise here as much as similar experiences, if any.

              • June 15, 2017 at 10:27 pm
              Newmanbell
              Participant
                My husband is stage 3b and has had sore and red eyes from yervoy. He just went to an optomologist 2 weeks ago for this, but his eyes seemed fine. He went on prednisone last week due to skin rash, fever, headaches and fatigue from her boy and everything is perfect including eyes. He will start to be weaned off this later this week so we will see how he does. Has yervoy helped you? Mark has his fourth treatment next week.
                Donna
                • June 16, 2017 at 3:53 pm
                BethVanVel
                Participant

                  I was diagnosed Stage IV in June 2015. Did Opdivo/Yervoy combo and then moved to Keytruda. I too now have floaters in my eye. As people in their early 30s (33 when diagnosed) don't tend to get floaters, I and my doctors/nurses do think it was a side effect. They seem to have stabilized since moving to the Keytruda. Besides that and some vitiligo/hair whitening I'm doing great.

                • June 16, 2017 at 4:38 pm
                sister of patient
                Participant

                  Hi Bonny – If this helps … my sister experienced the beginning of retinal detachment with the 2nd dose of ipi and it was discontinued immediately.

                  She was treated with two kinds of drops, prednizone and another and not sure of what the other one was but tho it stopped any further damage to the retinas, it caused cataracts. The retinal damage is permanent, she'll stay on the prednizone drops for life now and at some point will have to deal with the cataracts. 

                  While all that was happening, she had lots of floaters and "shooting stars" >> all of it stopped after the eye problem settled, so, yes, we attributed it to the ipi too. This was a year ago and my sister is just a year older than you.

                  Wishing you all the best outcomes!!

                  Barb

                  • June 29, 2017 at 2:38 pm
                  Dhva
                  Participant

                    Hi – my son is currently being treated for a second time for acute anterior uveitis. It has been reported to BMS and is an adverse reaction to ipi.  He has an ipi treatment scheduled for July and if he develops uveitis again, his treatments will be concluded to protect his vision. Definitely contact your onc and a good ophthalmologist! Good luck!

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