JAC-1 v P13 Kinase Trial is the winner!

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  • Post
    • September 22, 2016 at 2:26 pm
    Julie in SoCal
    Participant

      Greetings Friends,

      Yesterday I saw the Rock Star and did the "paper work" and body work (blood, ekg, and pee in a cup) to join INCB 39110-17.  I'll have to have scans again but provided lung tumor is still there (short of a miracle, there's no reason it wouldn't be) I'll start Day 1 Cycle 1 next Wed- Phew!  Maybe this roller coaster ride is coming to a full and complete stop or at least maybe slow down a little.

      I don't know if I'm on the JAC1 or PI3-k arm, but either way I'll get it a drug with Pembo and I've responded Pembro well in the past. So I'm hopeful.

      Meanwhile I'm tired.  All the hurry up and wait has been stressful.  Not knowing what the plan is has taken a toll. I'm very glad to have a plan.

      Thanks again for being fellow companions on this wild ride.

      Shalom,

      Julie

       

       

    Viewing 26 reply threads
    • Replies
        • September 22, 2016 at 2:43 pm
        Casitas1
        Participant

          Julie this is wonderful news! Its good to know Rock Star has these trials and may have these options available if i progress on Pembro. I am there on Wednesdays. If i see you i will say hello. Of all the rides.. Melanoma is the Zipper to me.

          Good Luck, rest up and Fight on!

          Paul

          • September 22, 2016 at 2:43 pm
          Casitas1
          Participant

            Julie this is wonderful news! Its good to know Rock Star has these trials and may have these options available if i progress on Pembro. I am there on Wednesdays. If i see you i will say hello. Of all the rides.. Melanoma is the Zipper to me.

            Good Luck, rest up and Fight on!

            Paul

            • September 22, 2016 at 2:43 pm
            Casitas1
            Participant

              Julie this is wonderful news! Its good to know Rock Star has these trials and may have these options available if i progress on Pembro. I am there on Wednesdays. If i see you i will say hello. Of all the rides.. Melanoma is the Zipper to me.

              Good Luck, rest up and Fight on!

              Paul

                • September 22, 2016 at 2:51 pm
                Julie in SoCal
                Participant

                  Ha! The Zipper!  I love it.  Melanoma is the  Zipper!  Every summer the Zipper comes to town.  Every year I look at it and tease the kids about riding it.  One day they'll take me up on the offer to pay for their ticket and I'll be out a few bucks and a yearly jest.  May they never ride the Melanoma Zipper!  

                  Is you're in on Weds. Look for me and say hey.  I look just like my pix.  Shocking, I know.  It's always good to meet a fellow Melahomie. 

                  Shalom,

                  Julie

                  • September 22, 2016 at 2:51 pm
                  Julie in SoCal
                  Participant

                    Ha! The Zipper!  I love it.  Melanoma is the  Zipper!  Every summer the Zipper comes to town.  Every year I look at it and tease the kids about riding it.  One day they'll take me up on the offer to pay for their ticket and I'll be out a few bucks and a yearly jest.  May they never ride the Melanoma Zipper!  

                    Is you're in on Weds. Look for me and say hey.  I look just like my pix.  Shocking, I know.  It's always good to meet a fellow Melahomie. 

                    Shalom,

                    Julie

                    • September 22, 2016 at 2:51 pm
                    Julie in SoCal
                    Participant

                      Ha! The Zipper!  I love it.  Melanoma is the  Zipper!  Every summer the Zipper comes to town.  Every year I look at it and tease the kids about riding it.  One day they'll take me up on the offer to pay for their ticket and I'll be out a few bucks and a yearly jest.  May they never ride the Melanoma Zipper!  

                      Is you're in on Weds. Look for me and say hey.  I look just like my pix.  Shocking, I know.  It's always good to meet a fellow Melahomie. 

                      Shalom,

                      Julie

                    • September 22, 2016 at 2:48 pm
                    snow white
                    Participant

                      Hi Julie,

                      My name is Jennifer and I live in So. Cal as well, I am in the South Bay Area.  My Dad is in the process of starting treatment.  Don't know if I am allowed on here to ask the Name of your Doctor?  He (my Dad) is currently seeing doc's at USC and Hoag, also seeking a 3rd opinion at City of Hope.  

                      It sounds like you have a good plan of action.  I wish you the best.

                      • September 22, 2016 at 2:48 pm
                      snow white
                      Participant

                        Hi Julie,

                        My name is Jennifer and I live in So. Cal as well, I am in the South Bay Area.  My Dad is in the process of starting treatment.  Don't know if I am allowed on here to ask the Name of your Doctor?  He (my Dad) is currently seeing doc's at USC and Hoag, also seeking a 3rd opinion at City of Hope.  

                        It sounds like you have a good plan of action.  I wish you the best.

                        • September 22, 2016 at 2:48 pm
                        snow white
                        Participant

                          Hi Julie,

                          My name is Jennifer and I live in So. Cal as well, I am in the South Bay Area.  My Dad is in the process of starting treatment.  Don't know if I am allowed on here to ask the Name of your Doctor?  He (my Dad) is currently seeing doc's at USC and Hoag, also seeking a 3rd opinion at City of Hope.  

                          It sounds like you have a good plan of action.  I wish you the best.

                            • September 22, 2016 at 2:54 pm
                            Julie in SoCal
                            Participant

                              Hi Jennifer.  

                              I think it's allowed.  It's easily figured out through my profile, so I don't have any problems saying that RSDoc is Steven J O'Day and you can find him at Providence/St. John in Santa Monica. 

                              Shalom,

                              Julie

                               

                              • September 22, 2016 at 2:54 pm
                              Julie in SoCal
                              Participant

                                Hi Jennifer.  

                                I think it's allowed.  It's easily figured out through my profile, so I don't have any problems saying that RSDoc is Steven J O'Day and you can find him at Providence/St. John in Santa Monica. 

                                Shalom,

                                Julie

                                 

                                • September 22, 2016 at 2:54 pm
                                Julie in SoCal
                                Participant

                                  Hi Jennifer.  

                                  I think it's allowed.  It's easily figured out through my profile, so I don't have any problems saying that RSDoc is Steven J O'Day and you can find him at Providence/St. John in Santa Monica. 

                                  Shalom,

                                  Julie

                                   

                                  • September 22, 2016 at 3:58 pm
                                  snow white
                                  Participant

                                    Thank you! I am a newbie and didn't think to look in your profile!

                                    • September 22, 2016 at 3:58 pm
                                    snow white
                                    Participant

                                      Thank you! I am a newbie and didn't think to look in your profile!

                                      • September 22, 2016 at 3:58 pm
                                      snow white
                                      Participant

                                        Thank you! I am a newbie and didn't think to look in your profile!

                                        • September 26, 2016 at 11:41 pm
                                        Julie in SoCal
                                        Participant

                                          Sorry Jennifer, I didn't mean to say you should have looked at my profile.  I think I was just thinking out loud with my fingers… My appologies!

                                          Julie

                                          • September 26, 2016 at 11:41 pm
                                          Julie in SoCal
                                          Participant

                                            Sorry Jennifer, I didn't mean to say you should have looked at my profile.  I think I was just thinking out loud with my fingers… My appologies!

                                            Julie

                                            • September 27, 2016 at 5:02 am
                                            snow white
                                            Participant

                                              no worries smiley

                                              • September 27, 2016 at 5:02 am
                                              snow white
                                              Participant

                                                no worries smiley

                                                • September 27, 2016 at 5:02 am
                                                snow white
                                                Participant

                                                  no worries smiley

                                                  • September 26, 2016 at 11:41 pm
                                                  Julie in SoCal
                                                  Participant

                                                    Sorry Jennifer, I didn't mean to say you should have looked at my profile.  I think I was just thinking out loud with my fingers… My appologies!

                                                    Julie

                                                  • September 22, 2016 at 3:16 pm
                                                  Mat
                                                  Participant

                                                    Good luck with the trial Julie!

                                                    • September 22, 2016 at 3:16 pm
                                                    Mat
                                                    Participant

                                                      Good luck with the trial Julie!

                                                      • September 22, 2016 at 3:16 pm
                                                      Mat
                                                      Participant

                                                        Good luck with the trial Julie!

                                                        • September 22, 2016 at 3:37 pm
                                                        jbronicki
                                                        Participant

                                                          That's great news and wishing you a non roller coaster rest of the year (maybe a lazy river like ride)!  Good luck on the trial! 

                                                          • September 22, 2016 at 3:37 pm
                                                          jbronicki
                                                          Participant

                                                            That's great news and wishing you a non roller coaster rest of the year (maybe a lazy river like ride)!  Good luck on the trial! 

                                                            • September 22, 2016 at 3:37 pm
                                                            jbronicki
                                                            Participant

                                                              That's great news and wishing you a non roller coaster rest of the year (maybe a lazy river like ride)!  Good luck on the trial! 

                                                              • September 22, 2016 at 3:38 pm
                                                              WithinMySkin
                                                              Participant
                                                                I’m so glad things are moving along, Julie! Hurry up and wait is the pits…Every day of waiting feels like an eternity. So glad you’ve got a plan and the treatment will start soon. You can breathe again come Wednesday!
                                                                • September 22, 2016 at 3:38 pm
                                                                WithinMySkin
                                                                Participant
                                                                  I’m so glad things are moving along, Julie! Hurry up and wait is the pits…Every day of waiting feels like an eternity. So glad you’ve got a plan and the treatment will start soon. You can breathe again come Wednesday!
                                                                  • September 22, 2016 at 3:38 pm
                                                                  WithinMySkin
                                                                  Participant
                                                                    I’m so glad things are moving along, Julie! Hurry up and wait is the pits…Every day of waiting feels like an eternity. So glad you’ve got a plan and the treatment will start soon. You can breathe again come Wednesday!
                                                                    • September 22, 2016 at 4:17 pm
                                                                    SABKLYN
                                                                    Participant

                                                                      Good luck Julie!

                                                                      • September 22, 2016 at 4:17 pm
                                                                      SABKLYN
                                                                      Participant

                                                                        Good luck Julie!

                                                                        • September 22, 2016 at 4:17 pm
                                                                        SABKLYN
                                                                        Participant

                                                                          Good luck Julie!

                                                                          • September 22, 2016 at 7:47 pm
                                                                          Bubbles
                                                                          Participant

                                                                            Hang in there! Wishing you my best! C

                                                                            • September 22, 2016 at 7:47 pm
                                                                            Bubbles
                                                                            Participant

                                                                              Hang in there! Wishing you my best! C

                                                                              • September 22, 2016 at 7:47 pm
                                                                              Bubbles
                                                                              Participant

                                                                                Hang in there! Wishing you my best! C

                                                                                • September 22, 2016 at 9:42 pm
                                                                                BrianP
                                                                                Participant

                                                                                  Nice work Julie.  I think you are well on your way to kicking butt again.

                                                                                  Not sure if you caught my post several weeks ago.  As far as I know there's no published on response rates for patients who are retreated with Anti-PD1 after responding the first time but in my conversation with Dr. Weber his gut feeling was when the data is mature it would show about a 70% success rate for reinduction.  With your added kick of JAC1 or PI3-k I'm very optimistic for you.

                                                                                  Brian

                                                                                  • September 22, 2016 at 9:42 pm
                                                                                  BrianP
                                                                                  Participant

                                                                                    Nice work Julie.  I think you are well on your way to kicking butt again.

                                                                                    Not sure if you caught my post several weeks ago.  As far as I know there's no published on response rates for patients who are retreated with Anti-PD1 after responding the first time but in my conversation with Dr. Weber his gut feeling was when the data is mature it would show about a 70% success rate for reinduction.  With your added kick of JAC1 or PI3-k I'm very optimistic for you.

                                                                                    Brian

                                                                                    • September 22, 2016 at 9:42 pm
                                                                                    BrianP
                                                                                    Participant

                                                                                      Nice work Julie.  I think you are well on your way to kicking butt again.

                                                                                      Not sure if you caught my post several weeks ago.  As far as I know there's no published on response rates for patients who are retreated with Anti-PD1 after responding the first time but in my conversation with Dr. Weber his gut feeling was when the data is mature it would show about a 70% success rate for reinduction.  With your added kick of JAC1 or PI3-k I'm very optimistic for you.

                                                                                      Brian

                                                                                        • September 23, 2016 at 5:01 pm
                                                                                        Julie in SoCal
                                                                                        Participant

                                                                                          Thanks Brian!  I remember reading it and being both intrigued and encouraged, but I had since forgotten about it (too much other stress, I mean stuff on the brain).  I wasn't sure why I had a thought that staying on Pembro would be a good idea.  Now I know why I thought that.  Thanks for the very encouraging reminder!!  

                                                                                          Shalom,

                                                                                          Julie

                                                                                          • September 23, 2016 at 5:01 pm
                                                                                          Julie in SoCal
                                                                                          Participant

                                                                                            Thanks Brian!  I remember reading it and being both intrigued and encouraged, but I had since forgotten about it (too much other stress, I mean stuff on the brain).  I wasn't sure why I had a thought that staying on Pembro would be a good idea.  Now I know why I thought that.  Thanks for the very encouraging reminder!!  

                                                                                            Shalom,

                                                                                            Julie

                                                                                            • September 23, 2016 at 5:01 pm
                                                                                            Julie in SoCal
                                                                                            Participant

                                                                                              Thanks Brian!  I remember reading it and being both intrigued and encouraged, but I had since forgotten about it (too much other stress, I mean stuff on the brain).  I wasn't sure why I had a thought that staying on Pembro would be a good idea.  Now I know why I thought that.  Thanks for the very encouraging reminder!!  

                                                                                              Shalom,

                                                                                              Julie

                                                                                            • September 24, 2016 at 1:28 pm
                                                                                            jenny22
                                                                                            Participant

                                                                                              Hi Julie-

                                                                                              I am so happy to hear you have your plan in place……I know how stressful that time is when you are trying to make treatment decisions……we've all been there!

                                                                                              Want to wish you good luck as you begin…more more importantly I am hopeful this is the one for you and that it will be your last treatment.

                                                                                              Hope all goes well, keep us posted, and BEST OF LUCK!!!!

                                                                                               

                                                                                              jenny

                                                                                              • September 24, 2016 at 1:28 pm
                                                                                              jenny22
                                                                                              Participant

                                                                                                Hi Julie-

                                                                                                I am so happy to hear you have your plan in place……I know how stressful that time is when you are trying to make treatment decisions……we've all been there!

                                                                                                Want to wish you good luck as you begin…more more importantly I am hopeful this is the one for you and that it will be your last treatment.

                                                                                                Hope all goes well, keep us posted, and BEST OF LUCK!!!!

                                                                                                 

                                                                                                jenny

                                                                                                • September 24, 2016 at 1:28 pm
                                                                                                jenny22
                                                                                                Participant

                                                                                                  Hi Julie-

                                                                                                  I am so happy to hear you have your plan in place……I know how stressful that time is when you are trying to make treatment decisions……we've all been there!

                                                                                                  Want to wish you good luck as you begin…more more importantly I am hopeful this is the one for you and that it will be your last treatment.

                                                                                                  Hope all goes well, keep us posted, and BEST OF LUCK!!!!

                                                                                                   

                                                                                                  jenny

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