Combining drugs to treat melanoma

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  • Post
    • September 26, 2015 at 2:36 pm
    Bubbles
    Participant

      For you all:

      I put this post together and thought it might be helpful to some of you.  It includes a webinar with slides presented by Jeffrey Weber and Sanjiv Argwala about data attained from combination therapies (both targeted and immuntherapies) vs results when used alone, side effects, why they work better together, and possible ways to choose the best therapy for the patient.  While none of it is really "new" it does put things together in a fairly concise, understandable manner.  I listed what were some of the salient points to me, if you don't have time for the hour long video.

      http://chaoticallypreciselifeloveandmelanoma.blogspot.com/2015/09/pick-your-poison-weber-and-agarwala.html

      While nothing is written in stone….we've come a long way baby!!!  Thanks again for the link, Steven.  I wish you all my best.  Celeste

    Viewing 14 reply threads
    • Replies
        • September 26, 2015 at 8:45 pm
        Polymath
        Participant

          Celeste,

          Thanks for this helpful summary

          Aloha, Gary

          • September 26, 2015 at 8:45 pm
          Polymath
          Participant

            Celeste,

            Thanks for this helpful summary

            Aloha, Gary

            • September 26, 2015 at 8:45 pm
            Polymath
            Participant

              Celeste,

              Thanks for this helpful summary

              Aloha, Gary

              • September 27, 2015 at 1:16 am
              BrianP
              Participant

                Awesome Cliff notes Celeste.  Reminds me of how I got through college. 🙂 

                Brian

                • September 27, 2015 at 1:16 am
                BrianP
                Participant

                  Awesome Cliff notes Celeste.  Reminds me of how I got through college. 🙂 

                  Brian

                  • September 27, 2015 at 1:16 am
                  BrianP
                  Participant

                    Awesome Cliff notes Celeste.  Reminds me of how I got through college. 🙂 

                    Brian

                    • September 27, 2015 at 9:19 pm
                    Rita and Charles
                    Participant

                      Hi Celeste, 

                      My husband has been on this combo for about 2 3/4 months. The first CT Scan was really positive – 50% reduction in the lung tumor and  lymph node activity has regressed.  BUT a few weeks ago, his vision in his left eye was impacted. His opthamologist ran tests and he has developed Iritus as a result of the BRAF combo side effect – very rare, but he has it!  Now, to heal the eye he needs to stop the combo…………..should we be scared out of our minds? His vison vs. more growth?

                       

                      Rita

                      • September 27, 2015 at 9:19 pm
                      Rita and Charles
                      Participant

                        Hi Celeste, 

                        My husband has been on this combo for about 2 3/4 months. The first CT Scan was really positive – 50% reduction in the lung tumor and  lymph node activity has regressed.  BUT a few weeks ago, his vision in his left eye was impacted. His opthamologist ran tests and he has developed Iritus as a result of the BRAF combo side effect – very rare, but he has it!  Now, to heal the eye he needs to stop the combo…………..should we be scared out of our minds? His vison vs. more growth?

                         

                        Rita

                          • September 28, 2015 at 1:27 am
                          Bubbles
                          Participant

                            Hi Rita,

                            Sorry you and your husband are suffering with that.  It sounds as though with a break in treatment and possibly steriods (or whatever treatment the oncs and ophthmologists deem appropriate), from the info reported…especially if you look at the post I made about treating side effects….they should hopefully be able to get your husband's vision under control.  Then, when you think about what the docs said regarding choosing treatment….with his reduction in tumor burden, it sounds a s though your husband would be a candidate to now move to an anti-PD1 product or to the ipi/nivo combo.  Some folks have been advocating use of the BRAF/MEK combo in that way from the start…regardless of side effects.  Hit the melanoma hard, get some tumor reduction quickly, then switch to immunotherapy.  I don't presume to know your husband's case and condition enough to say for certain…but that is what I would certainly be asking about.  I wish you both my best. C

                            • September 28, 2015 at 1:27 am
                            Bubbles
                            Participant

                              Hi Rita,

                              Sorry you and your husband are suffering with that.  It sounds as though with a break in treatment and possibly steriods (or whatever treatment the oncs and ophthmologists deem appropriate), from the info reported…especially if you look at the post I made about treating side effects….they should hopefully be able to get your husband's vision under control.  Then, when you think about what the docs said regarding choosing treatment….with his reduction in tumor burden, it sounds a s though your husband would be a candidate to now move to an anti-PD1 product or to the ipi/nivo combo.  Some folks have been advocating use of the BRAF/MEK combo in that way from the start…regardless of side effects.  Hit the melanoma hard, get some tumor reduction quickly, then switch to immunotherapy.  I don't presume to know your husband's case and condition enough to say for certain…but that is what I would certainly be asking about.  I wish you both my best. C

                              • September 28, 2015 at 1:27 am
                              Bubbles
                              Participant

                                Hi Rita,

                                Sorry you and your husband are suffering with that.  It sounds as though with a break in treatment and possibly steriods (or whatever treatment the oncs and ophthmologists deem appropriate), from the info reported…especially if you look at the post I made about treating side effects….they should hopefully be able to get your husband's vision under control.  Then, when you think about what the docs said regarding choosing treatment….with his reduction in tumor burden, it sounds a s though your husband would be a candidate to now move to an anti-PD1 product or to the ipi/nivo combo.  Some folks have been advocating use of the BRAF/MEK combo in that way from the start…regardless of side effects.  Hit the melanoma hard, get some tumor reduction quickly, then switch to immunotherapy.  I don't presume to know your husband's case and condition enough to say for certain…but that is what I would certainly be asking about.  I wish you both my best. C

                              • September 27, 2015 at 9:19 pm
                              Rita and Charles
                              Participant

                                Hi Celeste, 

                                My husband has been on this combo for about 2 3/4 months. The first CT Scan was really positive – 50% reduction in the lung tumor and  lymph node activity has regressed.  BUT a few weeks ago, his vision in his left eye was impacted. His opthamologist ran tests and he has developed Iritus as a result of the BRAF combo side effect – very rare, but he has it!  Now, to heal the eye he needs to stop the combo…………..should we be scared out of our minds? His vison vs. more growth?

                                 

                                Rita

                                • September 28, 2015 at 1:41 am
                                JoshF
                                Participant

                                  Celeste-

                                  thanks for posting…always great info. You're truly a gift to all of us in this forum.

                                  Josh

                                  • September 28, 2015 at 1:41 am
                                  JoshF
                                  Participant

                                    Celeste-

                                    thanks for posting…always great info. You're truly a gift to all of us in this forum.

                                    Josh

                                    • September 28, 2015 at 1:41 am
                                    JoshF
                                    Participant

                                      Celeste-

                                      thanks for posting…always great info. You're truly a gift to all of us in this forum.

                                      Josh

                                        • September 28, 2015 at 2:31 am
                                        Bubbles
                                        Participant

                                          Thanks to all my boys.  I appreciate your kind words, Josh.  But…there's an ANON out there…who may well disagree with you!!!  I'm sure you can imagine how much that hurts my heart.  Love to you all.  c

                                          • September 28, 2015 at 2:31 am
                                          Bubbles
                                          Participant

                                            Thanks to all my boys.  I appreciate your kind words, Josh.  But…there's an ANON out there…who may well disagree with you!!!  I'm sure you can imagine how much that hurts my heart.  Love to you all.  c

                                            • September 28, 2015 at 2:31 am
                                            Bubbles
                                            Participant

                                              Thanks to all my boys.  I appreciate your kind words, Josh.  But…there's an ANON out there…who may well disagree with you!!!  I'm sure you can imagine how much that hurts my heart.  Love to you all.  c

                                              • September 28, 2015 at 9:37 pm
                                              JoshF
                                              Participant

                                                Well the Anon's don't  do much for me but you're always there to support, provide info or lend advice. I'll stick with you.

                                                Josh

                                                • September 28, 2015 at 9:37 pm
                                                JoshF
                                                Participant

                                                  Well the Anon's don't  do much for me but you're always there to support, provide info or lend advice. I'll stick with you.

                                                  Josh

                                                  • September 28, 2015 at 9:37 pm
                                                  JoshF
                                                  Participant

                                                    Well the Anon's don't  do much for me but you're always there to support, provide info or lend advice. I'll stick with you.

                                                    Josh

                                                  • September 28, 2015 at 3:43 pm
                                                  dfeng
                                                  Participant

                                                    thanks for sharing.

                                                    • September 28, 2015 at 3:43 pm
                                                    dfeng
                                                    Participant

                                                      thanks for sharing.

                                                      • September 28, 2015 at 3:43 pm
                                                      dfeng
                                                      Participant

                                                        thanks for sharing.

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